Article
Rheumatology
Javier Bachiller-Corral, Alina Boteanu, Maria Jesus Garcia-Villanueva, Carlos de la Puente, Marcelino Revenga, M. Consuelo Diaz-Miguel, Ana Rodriguez-Garcia, Jose Luis Morell-Hita, Marta Valero, Carmen Larena, Maria Blazquez-Canamero, Carlos A. Guillen-Astete, Sandra Garrote, Cristina Sobrino, Carmen Medina-Quinones, Monica Vazquez-Diaz
Summary: The study found that patients with inflammatory rheumatic diseases accounted for 1.8% of the total hospitalized population. Patients with diseases such as rheumatoid arthritis, vasculitis, and systemic lupus erythematosus had a higher risk of hospitalization. Rheumatoid arthritis patients also showed a higher mortality rate in COVID-19, especially those treated with RTX.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Sasa Cucnik, Snezna Sodin-Semrl, John Varga, Katja Lakota
Summary: Adiponectin levels are deregulated in systemic autoimmune rheumatic diseases, with elevated levels in high inflammation diseases like rheumatoid arthritis, but low levels in diseases with less prominent inflammation like systemic sclerosis. Regulators of adiponectin gene expression and inflammatory cytokines may play a role in influencing total adiponectin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qiang-Wei Wang, Wei-Wei Lin, Yong-Jian Zhu
Summary: This study integrated and analyzed the expression patterns and clinical significance of TNF family-related genes in gliomas. It was found that the expression of most TNF family members was positively correlated and most were related to the overall survival of patients. A TNF family-based signature was developed and shown to be an independent prognostic marker for glioma patients.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Pharmacology & Pharmacy
Henri Chedotal, Dilip Narayanan, Katrine Povlsen, Charlotte H. Gotfredsen, Roberta Brambilla, Michael Gajhede, Anders Bach, Mads H. Clausen
Summary: Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in immune system homeostasis and various diseases. Biologics targeting TNF have limitations, and therefore, small molecules and alternative strategies for modulating TNF signaling are being explored.
DRUG DISCOVERY TODAY
(2023)
Article
Immunology
Hua Huang, Haochuan Yu, Xuanguang Li, Yongwen Li, Guangsheng Zhu, Lianchun Su, Mingbiao Li, Chen Chen, Min Gao, Di Wu, Ruihao Zhang, Peijun Cao, Hongyu Liu, Jun Chen
Summary: This study investigates the potential role of TNF family members in lung adenocarcinoma (LUAD). A TNF-related prognostic model is constructed and a TNF score is developed to predict overall survival and therapeutic responses in patients with LUAD. The findings improve our understanding of the function of TNF family members in LUAD and provide insights into personalized therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Yu-Jih Su, Hui-Ming Chen, Tien-Ming Chan, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Chun-Yu Lin, Chung-Yuan Hsu
Summary: This study aimed to investigate whether patients using disease-modifying anti-rheumatic drugs (DMARDs) may have different levels of risk for diabetes and to analyze other risk factors for diabetes. The results showed that certain DMARDs can reduce the risk of diabetes.
Article
Rheumatology
Timothy Arleo, David Tong, Julie Shabto, Ghazala O'Keefe, Arezou Khosroshahi
Summary: A case cohort study found that rheumatic disease patients infected with COVID-19 were more likely to require ICU admission, ventilation, and had higher mortality rates, especially for those using oral glucocorticoids who had higher hospitalization rates. Patients on anti-TNF alpha medications were hospitalized less frequently. These findings have important implications for medication choice in rheumatic disease patients during the ongoing spread of COVID-19.
CLINICAL RHEUMATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Roberta Figueiroa Souza, Marcos Antonio Ferreira Caetano, Henrique Inhauser Riceti Magalhaes, Patricia Castelucci
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) are types of Inflammatory Bowel Diseases (IBD) characterized by bowel necrosis and the involvement of enteric neurons and glial cells. The main inflammatory mediator is tumor necrosis factor-alpha (TNF-alpha), which is also associated with the production of other cytokines like interleukins (IL). TNF-alpha acts through two receptors, TNFR1 and TNFR2, which have been detected in IBD and their expression correlates with disease activity. Biologic agents targeting TNF-alpha have revolutionized IBD treatment by inducing and maintaining disease remission in a majority of patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Rheumatology
Daniel H. Solomon, Jon T. Giles, Katherine P. Liao, Paul M. Ridker, Pamela M. Rist, Robert J. Glynn, Rachel Broderick, Fengxin Lu, Meredith T. Murray, Kathleen Vanni, Leah M. Santacroce, Shady Abohashem, Philip M. Robson, Zahi Fayad, Venkatesh Mani, Ahmed Tawakol, Joan Bathon
Summary: This study found that adding either a TNFi or triple therapy led to clinically important improvements in vascular inflammation. However, adding a TNFi did not reduce arterial inflammation more than triple therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Marcin Stajszczyk, Izabela Obarska, Slawomir Jeka, Bogdan Batko
Summary: Although biologic disease modifying antirheumatic drugs have been on the market for several years, there are still significant disparities in access. Tumour necrosis factor inhibitors have been proven to be effective and safe for treating rheumatic musculoskeletal diseases. The emergence of biosimilars holds promise for reducing costs and providing more equitable access.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Virology
Ulf Martin Geisen, Ruben Rose, Franziska Neumann, Maria Ciripoi, Lena Vullriede, Hayley M. Reid, Dennis Kristopher Berner, Federico Bertoglio, Paula Hoff, Michael Hust, Ann Carolin Longardt, Thomas Lorentz, Gabriela Rios Martini, Carina Saggau, Jan Henrik Schirmer, Maren Schubert, Melike Suembuel, Florian Tran, Mathias Voss, Rainald Zeuner, Peter J. Morrison, Petra Bacher, Helmut Fickenscher, Sascha Gerdes, Matthias Peipp, Stefan Schreiber, Andi Krumbholz, Bimba Franziska Hoyer
Summary: The humoral immune response declines more rapidly with TNF-alpha inhibition in patients with chronic inflammatory disease. The efficacy of current vaccines against Omicron variants, including BA.2, is limited. Alterations in immune cell populations, changes in IgG affinity, and the ability to neutralize the virus were investigated in these at-risk patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Rheumatology
Nafise Ghalandari, Maarten M. Immink, Esther Roeder, Patricia C. J. Bruijning-Verhagen, Hieronymus Smeele, Hubertina Crijns, Nicoline A. T. van der Maas, Mireille N. Bekker, Elisabeth A. M. Sanders, Radboud J. E. M. Dolhain
Summary: This pilot study investigated the impact of TNFis treatment in pregnant women with rheumatic disease on Tdap vaccine responses and maternal anti-pertussis IgG antibody levels in newborns. The results showed lower levels of maternal anti-pertussis antibodies in newborns during TNFis treatment.
Article
Rheumatology
Erik Kemper, Nafise Ghalandari, Hetty Wintjes, Anneke Van Steensel-Boon, Laura Kranenburg, Annemarie Mulders, Hubertina Crijns, Hieronymus Smeele, Radboud J. E. M. Dolhain
Summary: The study shows that patients with RA are more likely to breast feed their offspring, which may be attributed to the availability of lactation-compatible medication and pregnancy counseling. The breastfeeding rates among patients with RA are similar to those in the general population.
Review
Gastroenterology & Hepatology
Gabrio Bassotti, Alessandro Fruganti, Fabrizio Stracci, Pierfrancesco Marconi, Katia Fettucciari
Summary: Clostridioides difficile (C. difficile) is increasingly colonizing humans and animals living with humans, with hypervirulent strains and mutated toxins. Subjects with inflammatory bowel disease (IBD) are more susceptible to C. difficile infection and relapse due to the cytotoxic synergism between C. difficile toxins and proinflammatory cytokines. In IBD subjects, the inflammatory state in the colon increases the susceptibility to C. difficile infection, enhances the cytotoxic activity of toxins, and induces a greater expression of receptors for toxins that lead to cell death by necrosis. Current therapeutic approaches involve monitoring of C. difficile colonization and reducing proinflammatory cytokine levels, with future perspectives including targeted therapy using bacteriophages.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Benjamin L. Cohen, Phillip Fleshner, Sunanda Kane, Hans H. Herfarth, Nicole Palekar, Francis A. Farraye, Jonathan A. Leighton, Jeffry A. Katz, Russell D. Cohen, Mark E. Gerich, Raymond K. Cross, Peter D. R. Higgins, Andrew Tinsley, Sarah Glover, Corey A. Siegel, Jaime L. Bohl, Heba Iskandar, Jiayi Ji, Liangyuan Hu, Bruce E. Sands
Summary: The aim of this study was to determine whether preoperative treatment of inflammatory bowel disease (IBD) with tumor necrosis factor inhibitors (TNFis) increases the risk of postoperative infectious complications. The results showed that preoperative TNFi exposure was not associated with postoperative infectious complications.
Letter
Rheumatology
Kimme L. Hyrich, Martin Schaefer, Anja Strangfeld, Loreto Carmona, Laure Gossec, Elsa F. Mateus, Saskia Lawson-Tovey, Milena Gianfrancesco, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jose B. Nergon, Maria A. Lopez-Olivo, Loreto Carmona, Robin Christensen, Francesca Ingegnoli, Natalia Zamora, Jorge I. Gamez-Nava, Laura Gonzalez-Lopez, Vibeke Strand, Niti Goel, Tiffany Westrich-Robertson, Maria E. Suarez-Almazor
Summary: This study aimed to identify patient-centered domains with long-term relevance to people with rheumatoid arthritis (RA). Semi-structured individual cognitive interviews were conducted with RA patients from five different countries. Six main themes were identified, including living with symptoms and functional limitations, lack of participation, partner and family issues, risk of damage to vital organs, coping strategies, and healthcare concerns. These domains are seldom measured in longitudinal registries and should be considered in patient-centered longitudinal studies.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Jose-Antonio Bernal, Mariano Andres, Salvador Lopez-Salguero, Vega Jovani, Paloma Vela-Casasempere, Eliseo Pascual
Summary: This study evaluated the agreement among multiple observers in crystal identification using compensated polarized microscopy. The results showed that the method remained consistent in detecting and identifying crystals in synovial fluid, confirming its high utility for clinical practice.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Rheumatology
Goncalo Boleto, Alvise Berti, Peter A. Merkel, Sibel Zehra Aydin, Haner Direskeneli, Christian Dejaco, Leslie C. Hassett, Loreto Carmona, Sofia Ramiro, O. M. E. R. A. C. T. Vasculitis Working Grp OMERACT Vasculitis Working Grp
Summary: This study systematically reviewed the measurement properties of outcome instruments used in large-vessel vasculitis (LVV). Out of the 3534 articles identified, 13 met the criteria, addressing 12 instruments. The Indian Takayasu Clinical Activity Score (ITAS) and the Disease Extent Index-Takayasu (DEI-Tak) showed the most adequate measurement properties for disease activity/damage in TA, while specific instruments for GCA and validated patient-reported outcomes for both GCA and TA were lacking.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Lihi Eder, Ashish J. Mathew, Philippe Carron, Heidi Bertheussen, Juan D. Canete, May Azem, Andrea Delle Sedie, Carlo Salvarani, Roberto Ranza, Ashley Elliott, Anthony Turkiewicz, Ricardo Acayaba de Toledo, Hulya Bukulmez, Maria S. Stoenoiu, Arthur M. Mandelin II, Michaela Koehm, Chris A. Lindsay, Evan Siegel, Philip J. Mease
Summary: This article summarizes existing evidence regarding pharmaceutical and nonpharmaceutical interventions for enthesitis in patients with psoriatic arthritis (PsA) to facilitate an evidence-based update of the Group for Research and Assessment in Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for PsA. The article found several classes of systemic conventional and advanced therapies and local measures were recommended for active enthesitis in patients with PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Cesar Magro-Checa, Sofia Ramiro, Inigo Rua-Figueroa, Norman Jimenez, Victor del Campo-Perez, Julia Martinez-Barrio, Maria Galindo-Izquierdo, Jaime Calvo-Alen, Esther Uriarte-Isacelaya, Eva Tomero-Muriel, Mercedes Freire-Gonzalez, Victor Martinez-Taboada, Eva Salgado, Paloma Vela, Natalia Mena-Vazquez, Alejandro Olive, Javier Narvaez, Raul Menor-Almagro, Gregorio Santos-Soler, Jose A. Hernandez-Beriain, Javier Manero-Ruiz, Elena Aurrecoechea-Aguinaga, Oihane Ibarguengoitia, Carlos Montilla-Morales, Gema Bonilla-Hernan, Vicente Torrente-Segarra, Tarek Salman-Monte, Inmaculada Ros-Vilamajo, Maria Jesus Garcia-Villanueva, Clara Moriano-Morales, Concepcion Fito-Manteca, Nuria Lozano-Rivas, Cristina Bohorquez, Jose M. Pego-Reigosa
Summary: This study analyzed the prevalence, incidence, survival, and contribution on mortality of major central nervous system (CNS) involvement in systemic lupus erythematosus (SLE). The results showed that 11.5% of SLE patients developed a total of 522 major CNS neuropsychiatric (NP)-SLE manifestations, and 12% of them died. It was found that cerebrovascular disease (CVD) and organic brain syndrome were associated with the highest mortality rates. The study concluded that major CNS NP-SLE could be an independent prognostic factor for poor survival.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Urology & Nephrology
A. Dominguez Garcia, C. Centeno Alvarez, J. Munoz Rodriguez, T. Bonfill Abella, M. Capdevila Gonzalo, L. de Verdonces Roman, O. Mayordomo Ferrer, P. Azuara Invernon, E. Casado Burgos, J. Prats Lopez, X. Serra Aracil
Summary: Metabolic acidosis is not common in patients with ileal urinary diversions more than one year after radical cystectomy, but it has secondary consequences on hematologic, renal, protein, lipid, and bone metabolism. We recommend close follow-up in patients with renal failure for early diagnosis and treatment.
ACTAS UROLOGICAS ESPANOLAS
(2023)
Article
Oncology
Beatriz Frade-Sosa, Chafik Alejandro Chacur, Josep M. Auge, Andres Ponce, Juan C. Sarmiento-Monroy, Ana Belen Azuaga, Nuria Sapena, Julio Ramirez, Virginia Ruiz-Esquide, Rosa Morla, Sandra Farietta, Patricia Corzo, Juan D. Canete, Raimon Sanmarti, Jose A. Gomez-Puerta
Summary: This study aimed to evaluate the serum levels of calprotectin in patients with rheumatic immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) treatment. The results showed that calprotectin can serve as a marker of inflammatory activity in patients with rheumatic irAEs.
Article
Genetics & Heredity
Enrique Casado, Carlos Gomez-Alonso, Guillem Pintos-Morell, Rosa Bou-Torrent, Ana Coral Barreda-Bonis, Jose Vicente Torregrosa, Jose Jesus Broseta-Monzo, Pedro Arango-Sancho, Sara Chocron-de-Benzaquen, Yoko Olmedilla-Ishishi, Begona Soler-Lopez
Summary: The TEAM Project analyzed the transition of patients with metabolic bone diseases from pediatric to adult care in Spain and developed consensus recommendations. A total of 86 physicians participated, reaching consensus on 45 statements. There were disagreements regarding the appropriate and feasible transition time and model. Lack of resources and coordination between pediatric and adult units were identified as the main barriers for successful transition.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Review
Rheumatology
Rosario Garcia-Vicuna, Xavier Juanola, Victoria Navarro-Compan, Manuel Jose Moreno-Ramos, Concepcion Castillo-Gallego, Mireia Moreno, Eva Galindez, Maria Montoro, Ismael Gomez, Francisco Jose Rebollo-Laserna, Estibaliz Loza
Summary: This study provides principles and recommendations for the management of axial spondyloarthritis, addressing specific scenarios and gaps in current guidelines. It highlights the importance of holistic and individualized care, integrating imaging and biomarker analysis.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Ying Ying Leung, Lihi Eder, Ana-Maria Orbai, Laura C. Coates, Maarten de Wit, Josef S. Smolen, Uta Kiltz, Penelope Palominos, Juan D. Canete, Rossana Scrivo, Andra Balanescu, Emanuelle Dernis, Sandra Meisalu, Martin Soubrier, Umut Kalyoncu, Laure Gossec
Correction
Geriatrics & Gerontology
Nicholas Fuggle, Nasser Al-Daghri, Olivier Bock, Jaime Branco, Olivier Bruyere, Enrique Casado, Etienne Cavalier, Bernard Cortet, Maarten de Wit, Andrea Giusti, Philippe Halbout, Nicholas C. C. Harvey, Mickael Hiligsmann, Jean-Marc Kaufman, Andreas Kurth, Stefania Maggi, Radmila Matijevic, Salvatore Minisola, Santiago Palacios, Regis Pierre Radermecker, Friederike Thomasius, Sansin Tuzun, Nicola Veronese, John A. Kanis, Jean-Yves Reginster, Rene Rizzoli, Cyrus Cooper
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Rheumatology
M. Calderon-Goercke, J. Loricera, C. Moriano, S. Castaneda, J. Narvaez, V. Aldasoro, O. Maiz, R. Melero, J. I. Villa, P. Vela, S. Romero-Yuste, J. L. Callejas, E. de Miguel, E. Galindez-Agirregoikoa, F. Sivera, J. C. Fernandez-Lopez, C. Galisteo, I. Ferraz-Amaro, J. Sanchez-Martin, L. Sanchez-Bilbao, M. A. Gonzalez-Gay, J. L. Hernandez, R. Blanco
Summary: This study assessed the effectiveness and safety of TCZ therapy optimization in GCA patients. Optimization was done by reducing dose or increasing dosing interval once complete remission was achieved. Optimized and non-optimized TCZ showed similar rates of prolonged remission and relapses, but severe infections were more frequent in the non-optimized group.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Francisco J. Rubino, Antonio Naranjo, Amparo Molina, Sonia Fuentes, Fabiola Santana, Ricardo Navarro, Arturo Montesdeoca, Tito Fernandez, Jose A. Lorenzo, Soledad Ojeda
Summary: The identification of vertebral fractures is crucial in a Fracture Liaison Service (FLS). By analyzing the characteristics of 570 patients based on the route of identification (referral by other doctors, emergency registry or DXA-VFA assessment), we found that promoting referral by other doctors through a training campaign is effective.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Health Care Sciences & Services
Enrique Casado, Jose Rosas, Carlos Rubio-Terres, Dario Rubio-Rodriguez, Mitra Boolell, Ignacio Aristegui
Summary: This study estimated the cost-effectiveness of weekly gastro-resistant risedronate tablets compared with weekly alendronate tablets in the treatment of postmenopausal osteoporosis in Spain. The results showed that risedronate tablets can reduce fractures, increase quality-adjusted life years, and result in cost-savings.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)