Article
Endocrinology & Metabolism
Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Summary: This study found that serum EDA levels were significantly higher in newly diagnosed type 2 diabetes mellitus patients, and positively correlated with various metabolic indexes such as body mass index and fasting plasma glucose. Additionally, EDA levels were independently associated with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eskandar Taghizadeh, Najmeh Farahani, Rajab Mardani, Forough Taheri, Hassan Taghizadeh, Seyed Mohammad Gheibihayat
Summary: Familial combined hyperlipidemia (FCHL) is a common familial lipoprotein disorder with a prevalence ranging from 0.5% to 2% in different populations. The disease's etiology is complex and may be related to genetic variants, environmental factors, and lifestyles.
BIOCHEMICAL GENETICS
(2022)
Article
Nanoscience & Nanotechnology
Sawinee Ngernpimai, Janpen Thonghlueng, Yaowaret Phothikul, Apiwat Chompoosor, Raynoo Thanan, Theerapong Puangmali, Chadamas Sakonsinsiri
Summary: In this study, a highly sensitive fluorescent aptasensor was developed for detecting 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in urine. The aptasensor used aptamer-mediated quenching of amino-terminated oligo(ethylene glycol)-capped gold nanoparticles (NH2-TEG-AuNPs) towards green emissive carbon dots (G-CDs) as the detection mechanism. The system demonstrated high selectivity and sensitivity over a broad concentration range, and has the potential to be developed as a new platform for rapid screening of 8-oxo-dG.
ACS APPLIED NANO MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Sok Kuan Wong, Fitri Fareez Ramli, Adli Ali, Nurul Izzah Ibrahim
Summary: Metabolic syndrome is a cluster of metabolic dysregulations, including insulin resistance, obesity, hypertension, and dyslipidemia. This review summarizes the genetic information of cholesterol-related genes in metabolic syndrome, which may potentially serve as biomarkers for early prevention and management of the syndrome.
Article
Cardiac & Cardiovascular Systems
Mark Trinder, Diana Vikulova, Simon R. Pimstone, G. B. John Mancini, Liam Brunham
Summary: This study reveals that familial combined hyperlipidemia (FCHL) is a polygenic susceptibility disease associated with metabolic abnormalities. The cardiovascular risk associated with FCHL phenotype is similar to monogenic familial hypercholesterolemia, despite being more common.
Review
Biochemistry & Molecular Biology
Amaia Ezkurdia, Maria J. Ramirez, Maite Solas
Summary: Alzheimer's disease is a disease with a significant socioeconomic burden and a lack of effective treatment. It is highly associated with metabolic syndrome, especially type 2 diabetes mellitus. Insulin resistance is suggested to be the mechanism linking Alzheimer's disease and type 2 diabetes. The role of insulin action on other brain cell types, such as astrocytes, in the onset and/or development of Alzheimer's disease is still unexplored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Vinaya Simha, Ian R. Lanza, Surendra Dasari, Katherine A. Klaus, Nathan Le Brasseur, Ivan Vuckovic, Marcello C. Laurenti, Claudio Cobelli, John D. Port, K. Sreekumaran Nair
Summary: Familial partial lipodystrophy (FPL) is characterized by muscle hypertrophy and insulin resistance. However, FPL patients do not show increased muscle strength despite their muscularity, and experience earlier fatigue during exercise. This is accompanied by impaired mitochondrial function and altered gene expression, which may explain the metabolic abnormalities and skeletal muscle dysfunction in FPL patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Lin Liu, Chen-Xi Liang, Xiao-Wei Wang, Ke-Xin Pei, Xin-Di Ma, Chun-Xi Zhang, Jing-Hui Dong, Ming-Ming Gao, Jia-Wei Liao
Summary: This study found that surgical removal of adipose tissue before obesity onset did not effectively prevent hyperlipidemia, insulin resistance, fatty liver, or atherosclerosis in a mouse model.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Francis Feldman, Mireille Koudoufio, Ramy El-Jalbout, Mathilde Foisy Sauve, Lena Ahmarani, Alain Theophile Sane, Nour-El-Houda Ould-Chikh, Thierry N'Timbane, Natalie Patey, Yves Desjardins, Alain Stintzi, Schohraya Spahis, Emile Levy
Summary: The study investigates the efficacy of cranberry proanthocyanidins (PACs) in improving metabolic syndrome (MetS) and liver complications. The results show that PACs can alleviate obesity, insulin resistance, and hyperlipidemia, and reduce oxidative stress and inflammation. Additionally, PACs improve fatty liver disease and inhibit liver gluconeogenesis.
Review
Hematology
Dimitra Aravani, Eva Kassi, Antonios Chatzigeorgiou, Styliani Vakrou
Summary: Cardiometabolic syndrome (CMS) is a global epidemic characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia, with approximately 25% prevalence in adults globally. Various mouse models, induced through genetic manipulation or specific diets and drugs, have contributed significantly to the understanding of CMS pathophysiology and the development of therapies. Researchers should carefully select and validate the most appropriate model, considering the differences between animal strains and the relevance to human physiology.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Endocrinology & Metabolism
Daniel Eppel, Michael Feichtinger, Tina Lindner, Grammata Kotzaeridi, Ingo Rosicky, Guelen Yerlikaya-Schatten, Wolfgang Eppel, Peter Husslein, Andrea Tura, Christian S. Gobl
Summary: Research has shown that elevated triglycerides at the start of pregnancy are closely related to insulin resistance and beta-cell dysfunction, leading to higher mean glucose levels in early- and mid-gestation. Furthermore, pregnant women with elevated triglycerides in early pregnancy are at an increased risk of developing gestational diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Nutrition & Dietetics
Eugene Scharf, Evelyn Zeiler, Mackson Ncube, Patricia Kolbe, Su-Yeon Hwang, Alan Goldhamer, Toshia R. Myers
Summary: This study investigates the effects of prolonged water-only fasting followed by an exclusively whole-plant-food refeeding on cardiometabolic disease. The results suggest that at the end of fasting, blood pressure, abdominal circumference, LDL, and hsCRP decreased, but TG and HOMA-IR scores increased, indicating the need for further research.
Article
Chemistry, Medicinal
Yi Fang, Jun Wang, Yu Cao, Wenrui Liu, Lianxiang Duan, Jing Hu, Jinghua Peng
Summary: Theaflavins have multiple effects and mechanisms in improving obesity and its comorbidities, such as fatty liver, hypercholesterolemia, insulin resistance, and atherosclerosis.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Endocrinology & Metabolism
Guillaume Treiber, Alice Guilleux, Kevin Huynh, Oriane Bonfanti, Ania Flaus-Furmaniuk, David Couret, Natalie Mellet, Celine Bernard, Nathalie Le-Moullec, Berenice Doray, Isabelle Jeru, Jean-Christophe Maiza, Bhoopendrasing Domun, Muriel Cogne, Olivier Meilhac, Corinne Vigouroux, Peter J. Meikle, Estelle Nobecourt
Summary: The study investigated glucose tolerance, insulin response, and metabolic markers in FPLD2 patients, revealing a high prevalence of diabetes and prediabetes. Early diagnosis and treatment are necessary.
DIABETES & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Ya-Fei Liu, Huan-Huan Wang, Yin-Hong Geng, Liang Han, Sheng-Hao Tu, Hui Wang
Summary: The prevalence of metabolic syndrome (MetS) is increasing worldwide, leading to MetS-associated kidney disease. Traditional theories suggest using multiple medications to control blood pressure, lipid levels, blood glucose, and obesity, as well as improve insulin resistance. However, this approach may reduce patients' compliance and increase adverse reactions. Therefore, complementary and alternative medicine, such as berberine (BBR), is being explored for its potential efficacy and safety in addressing MetS through various pathways and targets. This article elaborates on the effects and mechanisms of BBR on different aspects of MetS and kidney diseases, highlighting the need for further clinical trials.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Patrice Marques, Elena Domingo, Arantxa Rubio, Sergio Martinez-Hervas, Juan F. Ascaso, Laura Piqueras, Jose T. Real, Maria-Jesus Sanz
Summary: Inhibiting PCSK9 function can impact systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions, enhancing T-regulatory cell activation, and reducing inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Delia Acevedo-Leon, Segundo Angel Gomez-Abril, Lidia Monzo-Beltran, Nuria Estan-Capell, Rafael Arroyo-Montanes, Celia Banuls, Jordi Salas-Salvado, Guillermo Saez
Summary: This study found that adherence to the Mediterranean diet can protect against colorectal cancer and reduce metabolic and oxidative DNA damage while improving antioxidant systems in patients.
Article
Peripheral Vascular Disease
Susana Martin-Vano, Alejandra Miralles-Abella, Pascual Castano, Gema Hurtado-Genoves, Maria Aguilar-Ballester, Andrea Herrero-Cervera, Angela Vinue, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: This study explores the involvement of the tumor necrosis factor superfamily (TNFSF) ligands in the gene expression signature associated with vascular smooth muscle cell plasticity. The results indicate that these ligands play a crucial role in maintaining the identity of vascular smooth muscle cells and preventing them from acquiring a genetic expression signature compatible with functional cellular plasticity.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2023)
Article
Biochemistry & Molecular Biology
Delia Acevedo-Leon, Lidia Monzo-Beltran, Laura Perez-Sanchez, Eva Naranjo-Morillo, Segundo Angel Gomez-Abril, Nuria Estan-Capell, Celia Banuls, Guillermo Saez
Summary: Oxidative stress and inflammation play important roles in chronic diseases, including colorectal cancer. This study found that oxidative stress markers have potential diagnostic value for early detection of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Zulema Rodriguez-Hernandez, Maria Grau-Perez, F. Javier Chaves, Ana Barbara Garcia-Garcia, Nuria Amigo, Daniel Monleon, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Laisa S. Briongos-Figuero, Jose L. Perez-Castrillon, Josep Redon, Maria Tellez-Plaza, Juan C. Martin-Escudero
Summary: This study evaluated the association between plasma metabolic patterns and bone fragility, taking into account redox balance and genetic variants. The results showed that metabolic patterns were related to bone fractures and bone mineral density. Participants with exposure to certain metal elements had increased risk of fractures. Genetic variants may also influence the relationship between metabolism and bone fragility.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ana Palanca, F. Javier Ampudia-Blasco, Jose Miguel Calderon, Inmaculada Sauri, Sergio Martinez-Hervas, Jose Luis Trillo, Josep Redon, Jose T. Real
Summary: The study aimed to assess the impact of GLP-1RA treatment in obese adults with type 2 diabetes and compare it with other glucose-lowering agents. The results showed that GLP-1RA users had lower persistence but higher medication adherence. Within 2 years, persistent GLP-1RA users showed better reduction in HbA1c. However, therapeutic inertia was observed in the study population.
Editorial Material
Biochemistry & Molecular Biology
Francisco Lara-Hernandez, Luis Alvarez, Javier Chaves, Ana-Barbara Garcia-Garcia
Article
Medicine, General & Internal
Sergio Valdes, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Eva Garcia-Escobar, Sara Garcia-Serrano, Wasima Oualla-Bachiri, Marta Garcia-Vivanco, Juan Luis Garrido, Victoria Gil, Fernando Martin-Llorente, Alfonso Calle-Pascual, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbes, F. Javier Chaves, Jose L. Galan-Garcia, Gabriel Aguilera-Venegas, Joan Carles Vallve, Nuria Amigo, Montse Guardiola, Josep Ribalta, Gemma Rojo-Martinez
Summary: The study aimed to assess the associations between exposure to air pollutants and lipoprotein measures in the adult population of Spain. The results showed that exposure to particulate matter and nitrogen dioxide was associated with lower levels of high-density lipoprotein cholesterol and particles, as well as increased risk of low high-density lipoprotein cholesterol and particles. Subgroup analysis further revealed that the effects of particulate matter and nitrogen dioxide were more pronounced in men and individuals with obesity.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Belen Sanchez-Garcia, Ana B. Garcia-Garcia, Felipe J. Chaves, Juan C. Martin-Escudero, Maria Jose Forner, Josep Redon, Raquel Cortes
Summary: Elevated plasma microRNA levels, particularly miR-126-3p, are associated with albuminuria in hypertensive patients, and may serve as prognostic markers for cardiovascular events. Further studies are needed to assess the potential role of miR-126-3p in evaluating endothelial dysfunction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rebeca Melero, Maria Elena Quiroz-Rodriguez, Francisco Lara-Hernandez, Josep Redon, Guillermo Saez, Laisa S. Briongos-Figuero, Jessica Abadia-Otero, Juan Carlos Martin-Escudero, F. Javier Chaves, Guillermo Ayala, Ana-Barbara Garcia-Garcia
Summary: This study found a significant association between genetic polymorphisms related to oxidative stress parameters and the risk of developing Type 2 Diabetes Mellitus in a general population from Spain, indicating the important role of genetic variations and their interaction with oxidative stress parameters in the risk of developing T2D.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Nutrition & Dietetics
Blanca Alabadi, Miguel Civera, Adrian De la Rosa, Sergio Martinez-Hervas, Mari Carmen Gomez-Cabrera, Jose T. Real
Summary: Body composition changes during aging, particularly loss of lean mass, can contribute to the development of age-associated diseases such as type 2 diabetes (T2D). T2D is also associated with increased oxidative stress (OS) that negatively affects skeletal muscle. This study aimed to investigate the differences in clinical and nutritional parameters, disease control, and OS in older patients with T2D based on their amount of lean mass. The findings indicate that older women with low fat-free mass and muscle mass have poorer T2D metabolic control, and those with low muscle mass exhibit higher levels of OS. Thus, low lean mass in geriatric T2D patients is associated with worse glycemic control and increased OS.
Article
Biology
Soraya Garcia-Sorribes, Francisco Lara-Hernandez, Iris Manzano-Blasco, Jessica Abadia-Otero, Eliseo Albert, Alba Mulet, Laisa Socorro Briongos-Figuero, Miriam Gabella-Martin, Ignacio Torres, Jaime Signes-Costa, David Navarro, Juan-Carlos Martin-Escudero, Ana-Barbara Garcia-Garcia, Felipe Javier Chaves
Summary: The novel coronavirus SARS-CoV-2 emerged at the end of 2019, causing the COVID-19 pandemic. Current detection techniques, such as RT-qPCR, are sensitive but time-consuming and expensive. To address this, rapid tests like antibody-antigen tests have been developed but with lower sensitivity. In this study, a faster and more sensitive COVID-19 diagnostic test based on RT-LAMP was developed, allowing diagnosis in 40 minutes and colorimetric detection in non-specialized centers.
Meeting Abstract
Peripheral Vascular Disease
Olga Martinez-Arroyo, Ana Ortega, Elena Solaz, Fernando Martinez, Sergio Martinez-Hervas, Josep Redon, Raquel Cortes
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Aguilar Ballester, S. Martin-Vano, A. Abella Miralles, G. Hurtado Genoves, A. Herrero-Cervera, A. M. Taberner Cortes, A. Vinue, S. Martinez-Hervas, H. Gonzalez-Navarro
Meeting Abstract
Cardiac & Cardiovascular Systems
G. Hurtado Genoves, S. Martin-Vano, A. Herrero-Cervera, M. Aguilar-Ballester, A. Vinue, A. M. Taberner Cortes, S. Martinez-Hervas, H. Gonzalez-Navarro
