Article
Cell Biology
Sema Oncel, Rashmi Gupta, Qinggang Wang, Marc D. Basson
Summary: The study found that ZN27 can improve aspirin-associated gastric mucosal injury by activating FAK, promoting gastric mucosal repair.
Article
Biology
Farah Al-Yassir, Ghalia Khoder, Subi Sugathan, Prashanth Saseedharan, Asma Al Menhali, Sherif M. Karam
Summary: The study demonstrates the beneficial effects of a probiotic mixture (De Simone Formulation) in protecting against gastric mucosal erosion by promoting proliferation of gastric epithelial stem cells, enhancing mucous production, and modulating the secretion of protective factors.
Article
Plant Sciences
Haiying Gong, Di Han, Zichen Luo, Qingping Zhu, Xiaolin Zhu, Sen Liu, Diping Chen
Summary: This study investigated the potential effects of Xiangshao Decoction (XST) on gastric mucosal injury in GU rats and explored the possible molecular mechanisms. The results showed that XST can improve oxidative stress injury and inflammatory response in GU rats and cell models, and its mechanism is mediated by the NRF2 signaling pathway.
Article
Biochemistry & Molecular Biology
Meltem Kolgazi, Sumeyye Cilingir, Ozgur Yilmaz, Merve Gemici, Hasan Yazar, Samed Ozer, Merve Acikel-Elmas, Serap Arbak, Guldal Gulec Suyen
Summary: The study found that caffeic acid can ameliorate ethanol-induced gastric mucosal damage, with the nitric oxide pathway contributing to this effect but a lack of evidence for the muscarinic cholinergic system's contribution.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Kaiwen Lin, Tang Deng, Huijuan Qu, Hongya Ou, Qifeng Huang, Bingmiao Gao, Xiaoliang Li, Na Wei
Summary: This study investigated the protective mechanism of total flavonoid of Alpinia officinarum Hance (FAOH) on acetic acid-induced chronic gastric ulcers (GU) in rats and ethanol-induced GES-1 cell damage. The results showed that FAOH reduced the area of gastric ulcers, reversed cell apoptosis, and decreased inflammation and oxidative stress.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuqing Wu, Zhiguang Duan, Linlin Qu, Yi Zhang, Chenhui Zhu, Daidi Fan
Summary: Ginsenoside Rh4, extracted from Panax ginseng, has various pharmacological activities and exerts gastroprotective effects against ethanol-induced gastric ulcers in rats. It reduces gastric injury, enhances antioxidant activity, mitigates inflammation and oxidative stress, regulates the PGE2-Cox-2 pathway, and inhibits MAPK/NF-kappa B signaling pathways. Additionally, it enhances the expression of Bcl-2 and decreases the expression of Bax and Fas, leading to a decrease in apoptotic cells in gastric tissues.
Article
Biochemistry & Molecular Biology
Mingxiao Cui, Qiang Ma, Zhong Zhang, Wen Li, Wanchao Chen, Peng Liu, Di Wu, Yan Yang
Summary: This study showed that semi-solid enzymolysis had positive effects on the physicochemical properties of fruiting body powders and polysaccharides from Hericium erinaceus, as well as protective effects against gastric mucosal injury. Semi-solid enzymolysis resulted in a reduction in particle size, changes in microstructure, and an increase in the contents of soluble polysaccharides and uronic acid. It also enhanced digestibility and improved the protective effects against ethanol-induced gastric mucosal injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mariano Ezequiel Vera, Maria Laura Mariani, Cristina Aguilera, Alicia Beatriz Penissi
Summary: This study aimed to determine the effectiveness of lactones dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one in treating gastric ulcer induced by mast cell activation. The results showed that these compounds can prevent gastric lesions caused by mast cell degranulation and serum serotonin increase, similar to sodium cromoglycate. These findings suggest that these lactones could be valuable for developing new therapeutic agents for digestive disorders associated with inappropriate mast cell activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Sook-Luan Ng, Nur Ain Azhar, Siti Balkis Budin, Norliwati Ibrahim, Nur Azurah Abdul Ghani, Norzana Abd Ghafar, Jia-Xian Law
Summary: This study compared the effects of platelet lysate (PL) derived from umbilical cord blood (CB) and peripheral blood (PB) on oral mucosal wound healing. The results showed that both CB-PL and PB-PL gels promoted the proliferation and wound closure of oral mucosal fibroblasts, with no statistical differences between the two gels. Therefore, CB-PL gel could be a potential new source of PL for regenerative treatment of oral mucosal wounds.
Article
Immunology
Yixuan Bai, Chenggang Lei, Na Zhang, Yuhui Liu, Zhengyu Hu, Yan Li, Ran Qi
Summary: The aim of this study was to identify clinical endoscopic indicators related to peri-ulcerative mucosal inflammation and to analyze whether the degree of peri-ulcerative mucosal inflammation appearance is an independent risk factor for gastric ulcer rebleeding. Through analysis, the risk factors for peri-ulcerative mucosal inflammation appearance were determined, and a risk assessment model was developed for early prediction of rebleeding.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Veterinary Sciences
Saskia Neubert, Christina Puff, Sven Kleinschmidt, Patricia Kammeyer, Alexandra von Altrock, Michael Wendt, Matthias Gerhard Wagener
Summary: Gastric ulcers are common in South American camelids and are difficult to diagnose clinically or by laboratory investigations. These ulcers are often chronic processes involving other organ systems, so regular monitoring of the animals' nutritional status and early detection of disease symptoms may help prevent gastric ulcers.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Romit Majumder, Madhuri Datta, Adrita Banerjee, Debasish Bandyopadhyay, Aindrila Chattopadhyay
Summary: This study explores the role of gastric endogenous MT level and its metabolizing enzyme AANAT in ketorolac-induced gastric toxicities. The results reveal that ketorolac decreases AANAT activity, leading to a decline in endogenous MT level and aggravating gastric toxicity. Pre-treatment with exogenous MT has been found to be protective in ameliorating this ulcerogenic process in rats challenged with ketorolac.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Xueyan Jia, Yihuai He, Lin Li, Delin Xu
Summary: This paper provides an overview of the therapeutic effects and pharmacological mechanisms of traditional Chinese medications on gastric mucosal injury, highlighting their remarkable capacity to restore gastric mucosa after damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Gyounghwan Kim, Hyun-Sang Park, Paul Shin, Taeguk Eom, Jin-Hui Yoon, Yong Jeong, Wang-Yuhl Oh
Summary: Blood flow dynamics in microvascular networks play a critical role in tissue and organ health. Direct blood cell flow imaging (DBFI) is a new imaging technique that allows visualization of individual blood cell motions without using any contrast agents, with high time resolution. DBFI has the potential to analyze blood flow dynamics in various vessels and has been demonstrated in applications such as quantifying 3D vascular networks, analyzing heartbeat-induced blood flow, and studying neurovascular coupling.
Article
Biochemistry & Molecular Biology
Dahee Yeo, Su-Jung Hwang, Ye-Seul Song, Hyo-Jong Lee
Summary: Alpha-humulene has been found to have a protective role against gastric injury in vivo and in vitro by inhibiting histamine release, reducing oxidative stress, increasing antioxidant levels, and stimulating mucosal protective factors. This compound shows potential as a drug candidate for the treatment of stress-induced or alcoholic gastritis.
