Review
Biotechnology & Applied Microbiology
Miroslawa Puskulluoglu, Izabela Michalak
Summary: This review focuses on marine-derived nanoparticles with potential oncological applications. It provides an overview of the production process, classification of organisms used for nanoparticle production, different types of nanoparticles with prospective applications in oncology, molecular pathways responsible for various nanomedicine applications, areas of nanoparticle implementation in oncology, and speculations about future directions.
Review
Biochemistry & Molecular Biology
Francisco Rodriguez, Pablo Caruana, Noa De la Fuente, Pia Espanol, Maria Gamez, Josep Balart, Elisa Llurba, Ramon Rovira, Raul Ruiz, Cristina Martin-Lorente, Jose Luis Corchero, Maria Virtudes Cespedes
Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.
Article
Engineering, Biomedical
Huican Duan, Meiqi Chang, Han Lin, Hui Huang, Wei Feng, Weitao Guo, Lina Wu, Yu Chen, Ruifang Zhang
Summary: This study develops two-dimensional silicene nanosheets as a photosensitizer for photodynamic therapy, based on a wet-chemical synthetic approach. The nanosheets exhibit unique physiochemical properties and biocompatibility, and their conjugation with specific targeting properties enables effective tumor growth inhibition. Additionally, the silicene nanosheets have excellent light absorption capacity, allowing for tumor-specific photoacoustic imaging and therapeutic guidance.
MATERIALS TODAY BIO
(2022)
Review
Biotechnology & Applied Microbiology
Mengyu Guo, Chenjie Xia, Yu Wu, Nong Zhou, Zhipeng Chen, Weidong Li
Summary: Cell membrane-coated biomimetic nanoplatforms have inherent properties that enhance drug delivery efficiency. Research progress on cell membrane biomimetic technology reveals broad prospects for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Aleksandra Zielinska, Marlena Szalata, Adam Gorczynski, Jacek Karczewski, Piotr Eder, Patricia Severino, Jose M. Cabeda, Eliana B. Souto, Ryszard Slomski
Summary: Nanopharmaceuticals have become a promising approach for the treatment of various types of cancers, with the emergence of nanotheragnostics combining diagnosis and therapy. Tools for physicochemical, pharmacokinetic, and biopharmaceutical characterization are essential for evaluating the potential of nanopharmaceuticals in cancer therapy.
Review
Pharmacology & Pharmacy
Anaida Kad, Archit Pundir, Shailendra Kumar Arya, Neha Bhardwaj, Madhu Khatri
Summary: This article discusses the challenges hindering the clinical translation of nanomedicines, including scale-up challenges, toxicology testing, manufacturing guidelines, and regulatory approvals. The article also explores the economic viability of the nanomedicine industry through an investigation of revenue data. Finally, the article provides recommendations to facilitate the translational pathway of nanomedicines and ensure commercial success.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Review
Chemistry, Multidisciplinary
Letao Yang, Kapil D. Patel, Christopher Rathnam, Ramar Thangam, Yannan Hou, Heemin Kang, Ki-Bum Lee
Summary: Extracellular vesicles (e.g., exosomes) carrying various biomolecules have great potential in biomedical applications, but their heterogeneity and inefficient uptake by recipient cells are critical barriers. Multifunctional nanomaterials, such as magnetic nanomaterials, can play crucial roles in addressing these issues and enhancing the applications of extracellular vesicles.
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Review
Chemistry, Multidisciplinary
Aira Sarkar, Sathish Dyawanapelly
Summary: AMD, the third leading cause of worldwide blindness that causes permanent central vision impairment in older people, has seen significant progress in diagnosis and therapy in recent years. Current diagnostic and therapeutic strategies are clinically limited, and intravitreal injection therapy has its shortcomings, leading to the investigation of engineered nanoformulations for managing AMD.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Respiratory System
Sarah Barthold, Nicole Kunschke, Xabier Murgia, Brigitta Loretz, Cristiane de Souza Carvalho-Wodarz, Claus-Michael Lehr
Summary: Nanopharmaceuticals are nanoparticles designed for medical purposes, offering improved drug safety and efficacy. They can control drug release and overcome biological barriers, but their safety needs to be tested and proven.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2023)
Review
Environmental Sciences
Silvia Berkner, Kathrin Schwirn, Doris Voelker
Summary: Advanced materials and nanomaterials have great potential in healthcare applications, especially in the development of nano-formulated vaccines for the SARS-CoV-2 pandemic. However, the environmental impact of these products is often overlooked. This article reviews the gaps in awareness, research, and regulatory guidance regarding the environmental consequences of advanced medicinal products and nanomedicines. Possible solutions are proposed to bridge these gaps and improve the assessment of human and environmental safety.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Marine & Freshwater Biology
Taiwo Hassan Akere, Aline Maria Zigiotto de Medeiros, Diego Stefani T. Martinez, Bashiru Ibrahim, Hanene Ali-Boucetta, Eugenia Valsami-Jones
Summary: This study examined the acute toxicity and bioaccumulation of graphene oxide-gold (GO-Au) nano-hybrid in neonates of Daphnia magna. The results showed no significant mortality or immobilization after exposure, but microscopic observation revealed uptake of the nanohybrid and internal damage in the gut of the organisms. Bioaccumulation of the GO-Au nanohybrid also occurred in a concentration-dependent manner. Continuous evaluation of the environmental risks from exposure to this nanohybrid and other advanced materials is crucial to prevent disruption to the ecosystem.
AQUATIC TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhen Zou, Libei He, Xiangxi Deng, Huangxiang Wang, Ziyun Huang, Qian Xue, Zhihe Qing, Yanli Lei, Ronghua Yang, Juewen Liu
Summary: The study reports the formation of Zn2+-driven RNA self-assembly forming spherical nanoparticles, while preserving the integrity and biological function of RNA, with excellent RNA-loading efficiency, pharmacokinetics, and bioavailability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Catia T. Perciani, Lewis Y. Liu, Lawrence Wood, Sonya A. MacParland
Summary: The use of engineered nanoparticles has shown promise in enhancing vaccine efficacy and host immune responses to viral and tumor antigens. By harnessing the properties of nanoparticles, it may be possible to overcome current obstacles in vaccinology and oncology.
Review
Chemistry, Physical
Angeles Valls-Chivas, Javier Gomez, Jose I. Garcia-Peiro, Felipe Hornos, Jose L. Hueso
Summary: Magnetic nanoplatforms loaded with enzymes are gaining increasing attention in biotechnology for their ability to improve catalytic activity and stability, as well as their recoverability. This review evaluates key parameters of enzyme-nanoparticle immobilization and highlights the use of magnetite nanoparticles as multifunctional vectors for enzyme anchoring. It also discusses recent applications of enzyme-MNP hybrids in cancer therapy.
