期刊
RNA BIOLOGY
卷 12, 期 6, 页码 628-642出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2015.1038012
关键词
Cancer genomics; transcriptome; bioinformatics; lncRNA
资金
- LUNGevity Foundation Career Development Award
- American Lung Association Biomedical Research Grant
- Susan G. Komen CCR Basic/Translational and Clinical Grant [CCR14301279]
A growing number of gene-centric studies have highlighted the emerging significance of lncRNAs in cancer. However, these studies primarily focus on a single cancer type. Therefore, we conducted a pan-cancer analysis of lncRNAs comparing tumor and matched normal expression levels using RNA-Seq data from similar to 3,000patients in 8solid tumor types. While the majority of differentially expressed lncRNAs display tissue-specific expression we discovered 229 lncRNAs with outlier or differential expression across multiple cancers, which we refer to as 'onco-lncRNAs'. Due to their consistent altered expression, we hypothesize that these onco-lncRNAs may have conserved oncogenic and tumor suppressive functions across cancers. To address this, we associated the onco-lncRNAs in biological processes based on their co-expressed protein coding genes. To validate our predictions, we experimentally confirmed cell growth dependence of 2novel oncogenic lncRNAs, onco-lncRNA-3 and onco-lncRNA-12, and a previously identified lncRNA CCAT1. Overall, we discovered lncRNAs that may have broad oncogenic and tumor suppressor roles that could significantly advance our understanding of cancer lncRNA biology.
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