Review
Medicine, General & Internal
Rula Sha, Jiaming Zhang, Fanjie Meng, Getu Zhaori
Summary: NT5DC2 plays a prognostic role in metastatic gastric cancer patients, indicating unfavorable prognosis.
Article
Cell Biology
Wenshuo Yang, Xiaohan Cui, Danping Sun, Guorui Sun, Zhibo Yan, Meng Wei, Zuoyang Wang, Wenbin Yu
Summary: POU5F1 plays a crucial role in maintaining cancer stem cell-like properties in gastric cancer cells. Overexpression of POU5F1 is associated with a poor prognosis in gastric cancer patients. POU5F1 enhances the proliferation, migration, and invasion of gastric cancer cells by triggering Epithelial-mesenchymal transition (EMT) and activating the NF-kappa B pathway. ATRA, a therapeutic agent, inhibits the expression of POU5F1 and effectively impedes the proliferation, migration, and invasion of gastric cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Jianjiao Lin, Huiqiong Zhu, Linjie Hong, Weimei Tang, Jing Wang, Hongsong Hu, Xiaosheng Wu, Yaying Chen, Guangnan Liu, Qiong Yang, Jiaying Li, Yusi Wang, Zhizhao Lin, Yizhi Xiao, Weiyu Dai, Miaojvan Huang, Guoxin Li, Aimin Li, Jide Wang, Li Xiang, Side Liu
Summary: HOXA6 gene acts as an oncogene in various cancers, and its upregulation in gastric cancer is associated with poor clinical outcomes. HOXA6 promotes cell proliferation, migration, and invasion in GC through interaction with PBX2, suggesting it may serve as a biomarker for disease progression in GC.
Article
Oncology
Zhenyu Yang, Sensen Duan, Xi'e Hu, Baishu Dai, Guoqiang Bao, Wei Xin
Summary: This research investigates the prognostic implications of KCNQ1 mRNA in gastric carcinoma (GC) using various databases. The results suggest that KCNQ1 mRNA expression is lower in GC tissue samples compared to normal counterparts and higher expression is associated with longer survival and other clinical characteristics. Additionally, KCNQ1 is involved in the metabolic process of GC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Shengbo Li, Xiaofan Yang, Wenqing Li, Zhenbing Chen
Summary: E2F1/2/3/5/8 play important roles in the tumor progression of gastric cancer, serving as potential biomarkers or therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Subhash Chand, Vikrant Mehta, Ratnesh K. Sharma, Anupkumar R. Anvikar, Harish Chander
Summary: Breast cancer, the most commonly diagnosed cancer worldwide, has a poor prognosis. This study found that CHAC2 expression was elevated in breast cancer patients and was associated with lower overall survival. These findings suggest that CHAC2 may be an important biomarker and have potential therapeutic implications in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Du, Shuang Hou, Zhou Chen, Wancheng Li, Xin Li, Wence Zhou
Summary: PKP3 is upregulated in pancreatic cancer tissues and is associated with a negative prognosis. It promotes the progression, migration, and invasive capacity of pancreatic cancer cells, and is involved in the regulation of the PI3K-Akt and MAPK signaling pathways. It inhibits CD8+ T-cell infiltration and immune cytokine expression in the tumor microenvironment. PKP3 is identified as a prospective independent predictive indicator and a potential target for immunotherapy in pancreatic cancer.
Article
Biotechnology & Applied Microbiology
He-Wei Zhang, Ying Guo, Lin-xiao Sun, Fu-biao Ni, Ke Xu
Summary: The study found that high expression of three members of SMADs (SMAD1, SMAD2, SMAD4) is associated with favorable overall survival of gastric cancer patients, while the expression level of SMAD3 indicates highly differentiated cancer. Surgical treatment is associated with high expression levels of SMAD1 and SMAD2, and the effect of Her2 on gastric cancer is not significant. Furthermore, inhibition of SMAD3 expression suppressed the proliferation and migration ability of gastric cancer cells through inducing apoptosis.
Article
Medicine, Research & Experimental
Yan-Jie Chen, Shu-Neng Luo, Hao Wu, Ning-Ping Zhang, Ling Dong, Tao-Tao Liu, Li Liang, Xi-Zhong Shen
Summary: This study found that the expression of IRF-2 was downregulated in gastric cancer tissues and was negatively correlated with the prognoses of gastric cancer patients. IRF-2 inhibits tumor growth by regulating the transcription of AMER-1 and the Wnt/β-catenin signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Lingling He, Wenjing He, Ji Luo, Minjuan Xu
Summary: Identification of key genes and the potential biomarker ENC1 in uterine corpus endometrial carcinoma (UCEC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yaxin Qi, Jun Wei, Xiaobo Zhang
Summary: The transcription factor NME2 plays a crucial role in maintaining the stemness of gastric cancer stem cells by suppressing apoptosis and enhancing the expression of anti-apoptosis genes. This study provides a new perspective on the relationship between transcription factors and the stemness maintenance of gastric cancer stem cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zhao Liu, Jiaxin Liu, Ruimiao Liu, Man Xue, Weifan Zhang, Xinhui Zhao, Jiang Zhu, Peng Xia
Summary: ZNF132 is downregulated by promoter methylation in various cancer types, including prostate cancer and esophageal squamous cell carcinoma. This study found that ZNF132 is downregulated in BC tissues and hypermethylation contributes to its downregulated expression. Furthermore, ZNF132 shows promise as a diagnostic and prognostic marker in BC.
Article
Oncology
Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Anna Willms, Christine Halske, Christian Roder, Sandra Kruger, Christoph Rocken, Thomas Becker, Holger Kalthoff, Anna Trauzold
Summary: HMGA2 expression in the nucleus is associated with tumor dedifferentiation and lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC). The presence of HMGA2 in both the cytoplasm and the nucleus of tumor cells is common, with stronger nuclear staining observed. Additionally, cytoplasmic HMGA2 expression correlates with lymph vessel and venous invasion, suggesting a potential role in nodal spread.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Cell Biology
Liqun Liang, Hongchun Kang, Junmei Jia
Summary: The long non-coding RNA HCP5 is upregulated in gastric cancer patients, leading to resistance to cisplatin (DDP) through the miR-128/HMGA2 axis. Knockdown of HCP5 reduces chemoresistance and promotes apoptosis in gastric cancer cells.
Article
Biochemistry & Molecular Biology
Zhouying Wu, Min Wang, Feng Li, Feng Wang, Jianchao Jia, Zongqi Feng, Xue Huo, Jie Yang, Wen Jin, Rina Sa, Wenming Gao, Lan Yu
Summary: In this study, it was found that HMGA2 promotes gastric cancer growth by affecting the S-G2/M phase transition instead of G0/G1 acceleration, and CDK13 is a direct target gene of HMGA2 with a positive relationship between the two.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)