Article
Immunology
Yiman Wang, Xuming Mao, Yangchun Liu, Yuyan Yang, Hongzhong Jin, Li Li
Summary: This study found that IL-13 concentration is elevated in the blood of BP patients and is associated with IL-13 gene polymorphism. The results suggest that IL-13 plays a role in the pathogenesis of BP and could potentially serve as a target for therapy and a prognostic marker.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Jacob T. Hough, Lei Zhao, Marco Lequio, Aidan J. Heslin, Huaping Xiao, Cade C. Lewis, Justin Zhang, Qian Bai, Mark R. Wakefield, Yujiang Fang
Summary: IL-32 is an interleukin cytokine that is associated with inflammation. It has been found to have both pro- and anti-tumor effects, making its role in cancer formation complex. Considering the role of IL-32 in various cancers and protein pathways is crucial when exploring potential therapeutic options for tumor treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Limin Zhang, Yan Ma, Bao Liu
Summary: We retrospectively analyzed the prognostic value of different lymph-node staging systems for early and advanced SRCCs and found that log odds of positive lymph nodes (LODDS) is a superior predictor compared to pN-stage and lymph-node metastasis rate (LNR). It is an independent risk factor associated with patient outcomes.
Article
Cell Biology
Ye Miao, Zhen-xing Zhang, Xu Feng, Wei-ming Sun
Summary: The study revealed that serum IL-33 levels upon admission were significantly associated with the prognosis of patients with ICH, with higher IL-33 levels correlating with better outcomes. Further studies on the underlying mechanisms are needed to confirm this relationship.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Rosa Molfetta, Mario Lecce, Nadia D. Milito, Erisa Putro, Giuseppe Pietropaolo, Caterina Marangio, Gianluca Scarno, Marta Moretti, Enrico De Smaele, Tiziana Santini, Giovanni Bernardini, Giuseppe Sciume, Angela Santoni, Rossella Paolini
Summary: Mast cells (MCs) are innate immune cells that play a multifaceted role in the tumor microenvironment (TME). Recent studies have shown that MCs contribute to the transition from chronic inflammation to cancer. However, MC-derived mediators can either promote tumor progression or exert anti-tumorigenic effects, depending on the microenvironmental stimuli. This study focused on a specific subset of MCs in a murine model of colitis-associated colorectal cancer and found that these tumor-associated MCs have a connective tissue phenotype and release interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. The presence of high levels of stem cell factor (SCF) and IL-33 in the tumor was found to shape the MC phenotype and promote the secretion of pro-inflammatory cytokines. This study highlights the importance of understanding the role of specific MC subsets in tumor progression.
CELL DEATH & DISEASE
(2023)
Article
Virology
Anuradha S. Tripathy, Siddhesh Vishwakarma, Diptee Trimbake, Yogesh K. Gurav, Varsha A. Potdar, Nitin D. Mokashi, Sudhir D. Patsute, Himanshu Kaushal, Manohar L. Choudhary, Bipin N. Tilekar, Prakash Sarje, Varsha S. Dange, Priya Abraham
Summary: The study found that patients infected with SARS-CoV-2 have higher levels of inflammatory cytokines and lower levels of antiviral cytokines compared to uninfected individuals. All key analytes were significantly lower in recovered individuals than in patients, but the level of CXCL10 was significantly higher in recovered patients than in controls, suggesting that the immune system of SARS-CoV-2 patients may take a longer time to normalize.
ARCHIVES OF VIROLOGY
(2021)
Article
Medicine, General & Internal
Emir Capkinoglu, Aydin Eray Tufan, Sinan Omeroglu, Mert Tanal, Onur Guven, Uygar Demir
Summary: This study aims to evaluate the prognostic significance of positive lymph nodes following surgery in patients with gastric adenocarcinoma. A total of 193 patients who underwent curative gastrectomy were included in this retrospective study. The results suggest that the positive lymph node ratio has some predictive value for prognosis in these patients.
Article
Oncology
Ran Xu, Yisheng Zhang, Jun Zhao, Ke Chen, Zhengguang Wang
Summary: In this retrospective study, clinicopathological data of 1224 lymph node-negative gastric cancer patients were collected. The study found that lymph node-negative status is an independent risk factor for prognosis, and patients with 3 or more lymph node metastases have a worse prognosis.
Article
Biochemistry & Molecular Biology
Letizia Scola, Rosa Maria Giarratana, Vincenzo Marinello, Valeria Cancila, Calogera Pisano, Giovanni Ruvolo, Giacomo Frati, Domenico Lio, Carmela Rita Balistreri
Summary: This study identified significant associations between IL-6 rs1800795G>C and IL-1B rs16944C>T SNPs with TAAA risk, and a synergistic effect of the combined rs1800795C/rs16944T genotype on TAAA pathogenesis and outcome.
Article
Otorhinolaryngology
Helene Stampe, Kathrine Kronberg Jakobsen, Jesper Filtenborg Tvedskov, Irene Wessel, Katalin Kiss, Jeppe Friborg, Amanda Oester Andersen, Christian Gronhoj, Christian von Buchwald, Anders Christensen
Summary: This study aims to investigate the thresholds for lymph node yield, lymph node density, and pN in patients with oral squamous cell carcinoma and their relation to survival outcomes. The results suggest that increased nodal yield, decreased LND, and decreasing number of pN are associated with significantly improved survival outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Surgery
Atsushi Yamamoto, Katsutoshi Shoda, Yoshihiko Kawaguchi, Hidenori Akaike, Ryo Saito, Naoki Ashizawa, Koichi Takiguchi, Shinji Furuya, Naohiro Hosomura, Hidetake Amemiya, Hiromichi Kawaida, Makoto Sudo, Hiroshi Kono, Kunio Mochizuki, Daisuke Ichikawa
Summary: This study found that patients with lymph node micrometastasis (LNMM) <1500 μm in diameter had a better prognosis in gastric cancer, suggesting LNMM may be an independent prognostic marker in patients with pN1 GC. Additionally, LNMM may impact the effectiveness of adjuvant chemotherapy in gastric cancer patients.
Review
Surgery
Mevlut Yordanagil, Metin Ercan, Adem Senturk, Bilge Elcin
Summary: This study aimed to analyze the importance and prognostic impact of 8a lymph node metastasis in patients with gastric cancer. The results showed that patients with 8a lymph node metastasis had lower overall survival and disease-free survival rates. Among pathological N2/3 patients, those with metastatic 8a lymph nodes had significantly lower overall and disease-free survival rates.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Medicine, General & Internal
Xiao-Qing Wang, Min Bao, Cheng Zhang
Summary: The study found that lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) have better prognostic efficacy than the traditional N staging method in cardia gastric adenocarcinoma with node metastasis. These two values can be promising substitutes for N staging and be incorporated with other independent prognostic factors for nomogram development.
Article
Biochemistry & Molecular Biology
Xianjuan Shen, Shan Kong, Shuo Ma, Lei Shen, Ming Zheng, Shiyi Qin, Jing Qi, Qiuhong Wang, Xiaopeng Cui, Shaoqing Ju
Summary: The circRNA hsa_circ_0000437 was found to play a significant role in gastric cancer progression, promoting cell proliferation, migration, invasion, and apoptosis resistance. It was also found to induce lymph node metastasis through the HSPA2-ERK signaling pathway. Clinical data showed that hsa_circ_0000437 was enriched in the serum of gastric cancer patients and was associated with lymph node metastasis. These findings suggest that hsa_circ_0000437 may serve as a potential biomarker for lymph node metastasis in gastric cancer patients.