Article
Microbiology
W. R. Ribeiro, A. G. Queiroz, E. Mendes, M. B. Casaro, C. M. Nascimento, L. S. S. F. Coelho, F. S. Martins, V. R. Leite-Silva, C. M. Ferreira
Summary: This study demonstrated that the probiotic Bifidobacterium longum 5(1A) has a prophylactic effect on oxazolone-induced allergic contact dermatitis-like skin inflammation in mice, reducing ear and dermal thickness as well as leukocyte infiltration. Additionally, acetate, a byproduct of B. longum 5(1A), was shown to prevent skin thickening, possibly indicating one mechanism of action. However, other factors are likely at play as both probiotic treatment and acetate treatment did not lead to identical results in terms of reducing inflammatory cytokines and chemokines.
BENEFICIAL MICROBES
(2021)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Biochemistry & Molecular Biology
Zhenzhen Zhang, Jin Zhao, Kuan Chen Lai, Laijun Lai
Summary: The study found that TAPBPL protein can significantly ameliorate CII-induced arthritis in mice and reduce the expression of inflammatory cytokines. The results suggest that TAPBPL protein has the potential to be used in the treatment of patients with RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Pan Shen, Weiji Lin, Xin Ba, Yao Huang, Zhe Chen, Liang Han, Kai Qin, Ying Huang, Shenghao Tu
Summary: Herba taxilli, composed of Taxillus chinensis, is used in traditional Chinese medicine to treat inflammation and arthritis. Quercetin, a key component, shows antiarthritic effects and may act through SIRT1 to target mitochondrial biogenesis in rheumatoid arthritis treatment. Further research is needed to fully understand the mechanisms involved.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Microbiology
Wimonrat Panpetch, Chitrasak Kullapanich, Cong Phi Dang, Peerapat Visitchanakun, Wilasinee Saisorn, Jutamas Wongphoom, Dhammika Leshan Wannigama, Arthid Thim-uam, Kanitha Patarakul, Naraporn Somboonna, Somying Tumwasorn, Asada Leelahavanichkul
Summary: The impact of gut fungi and (1 -> 3)-beta-D-glucan (BG) on uremia was explored by orally administering Candida albicans in mice with bilateral nephrectomy. The study found that Candida worsened intestinal injury and altered gut microbiota in the mice, resulting in the presence of bacteria, endotoxin, and glucan in the bloodstream.
Article
Immunology
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou, Fang Peng
Summary: The study demonstrates that SPD can protect CIA mice by inhibiting the polarization of M1 macrophages, reducing pro-inflammatory cytokines, and promoting the release of anti-inflammatory factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Allergy
Paulina Kowalczyk, Monika Majewska-Szczepanik, Anna Strzepa, Dominika Biala, Marian Szczepanik
Summary: The study found that diet-induced obesity significantly affects the response mediated by NK cells, exacerbating CHS reaction and causing inflammation in the liver.
CONTACT DERMATITIS
(2021)
Article
Plant Sciences
Mijin Kim, Bongjun Sur, Thea Villa, Seung Yeol Nah, Seikwan Oh
Summary: The study showed that Gintonin has anti-arthritic effects by inhibiting the expression of inflammatory mediators and preventing the nuclear translocation of NF-kappa B/p65. Additionally, it suppressed arthritis symptoms in a mice model of collagen-induced arthritis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Cell Biology
Linghuo Jiang, Huihui Xu, Yiying Gu, Liudan Wei
Summary: Candida albicans, a significant human fungal pathogen, senses and adapts to the host environment through the pH-responsive Rim101 pathway. In this study, we demonstrate that the regulation of cell wall remodeling is integrated through differential degrees of Phr1 glycosylation by both the pH-regulated Rim101 pathway and the calcium/calcineurin signaling pathway in C. albicans.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Kazunori Ninomiya, Hiroki Katagiri, Hajime Hara, Kayoko Fukui, Maiko Haga-Tsujimura, Ken Nakahara, Kenjirou Nakamura
Summary: Oral mucositis is a common problem among the elderly, but oral care can be difficult for them. This study aimed to compare the effectiveness of antifungal prophylaxis and oral care in preventing systemic Candida infection using a mice model. The results showed that antifungal prophylaxis was more effective than oral care in reducing colony forming units and preventing Candida dissemination in the blood. This suggests that antifungal prophylaxis may be a suitable option for individuals who have difficulty with oral care.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Immunology
Anqi Li, Zhanfeng Zhang, Xiaochen Ru, Yanfeng Yi, Xiaoyu Li, Jing Qian, Jue Wang, Xiaobing Yang, Yunliang Yao
Summary: Through gene expression analysis, a total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The analysis showed significant differences in the infiltration of 25 cells, and 603 immune-related genes were obtained through WGCNA, with 270 DEIRGs identified. Enrichment analysis indicated that DEIRGs were associated with immunity-related biological processes, and 4 candidate biomarkers were identified through the PPI network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Takahiro Yamada, Taku Nakashima, Takeshi Masuda, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Nobuhiko Kamada, Noboru Hattori
Summary: Increasing evidence suggests a link between intestinal microbiota, including fungi, and diseases in distal organs. This study aimed to investigate the impact of changes in intestinal fungal microbiota on the development of pulmonary fibrosis. Mice with Candida albicans overgrowth in the intestine, induced by oral administration of antibiotics and C. albicans, exhibited accelerated bleomycin-induced pulmonary fibrosis. These mice also showed enhanced Th17-type immune response, which was alleviated by IL-17A-neutralizing antibody treatment. The study highlights the involvement of IL-17A-mediated endothelial-mesenchymal transition in Candida albicans-exacerbated pulmonary fibrosis.
JOURNAL OF PATHOLOGY
(2023)
Article
Microbiology
Andrew S. Wagner, Stephen W. Lumsdaine, Mikayla M. Mangrum, Todd B. Reynolds
Summary: To effectively induce disease, Candida albicans masks immunogenic β(1,3)-glucan epitopes within its cell wall under a layer of mannosylated glycoproteins. Treatment with the antifungal drug caspofungin enhances the exposure (unmasking) of β(1,3)-glucan, making the fungal cells more visible to the host immune system and attenuating disease progression. Our study reveals a correlation between increased chitin synthesis and β(1,3)-glucan unmasking in response to caspofungin, suggesting that altered chitin synthesis drives increased unmasking during drug exposure.
Article
Pharmacology & Pharmacy
Chien-Fu Chen, Hsin-Pei Li, Ya-Hsuan Chao, Min-Yu Tu, Chih-Ching Yen, Ying-Wei Lan, Shang-Hsun Yang, Kowit-Yu Chong, Chi-Chien Lin, Chuan-Mu Chen
Summary: Kefir peptides (KPs) can alleviate symptoms of collagen-induced arthritis (CIA) in mice by inhibiting dendritic cell maturation and inflammatory cytokine release. This study demonstrates that KPs attenuate CIA by suppressing DC maturation and inflammatory cytokine releases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hsueh-Yu Lu, Wei-Chung Tsai, Jia-Shan Liu, Chung-Hsiung Huang
Summary: This study developed a nanoemulsion containing Cordyceps militaris polysaccharide and sesame oil, which demonstrated therapeutic effects on vaginal Candida infection. In addition, these formulations also modulated immune responses and alleviated inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)