Article
Polymer Science
Muhammad Abdullah Akram, Barkat Ali Khan, Muhammad Khalid Khan, Ali Alqahtani, Sultan M. Alshahrani, Khaled M. Hosny
Summary: The study successfully developed a polymeric emulgel of eugenol and linalool for the treatment of Trichophyton rubrum infections. The emulgel showed good physical properties and demonstrated significant effects in treating the infections both in vitro and in vivo, making it a promising topical treatment option.
Article
Biochemical Research Methods
Jessica Houang, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Alina Bekmukhametova, Antonio Lauto
Summary: The study demonstrated that photodynamic therapy using Rose Bengal can act against a broader spectrum of fungal pathogens, potentially expanding its clinical antifungal applications.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Microbiology
Connie F. Canete-Gibas, James Mele, Hoja P. Patterson, Carmita J. Sanders, Dora Ferrer, Victor Garcia, Hongxin Fan, Marjorie David, Nathan P. Wiederhold
Summary: Dermatophytes are common pathogens causing skin, hair, and nail infections in humans. A study evaluated the antifungal susceptibility profiles and species identification of dermatophytes received from North America, revealing relatively common terbinafine resistance and the presence of Trichophyton indotineae in multiple areas. Continued surveillance is necessary.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Microbiology
Nicole L. van der Weerden, Kathy Parisi, James A. Mckenna, Brigitte M. Hayes, Peta J. Harvey, Pedro Quimbar, Sean R. Wevrett, Prem K. Veneer, Owen Mccorkelle, Shaily Vasa, Rosemary Guarino, Simon Poon, Yolanda M. Gaspar, Michael J. Baker, David J. Craik, Rob B. Turner, Marc B. Brown, Mark R. Bleackley, Marilyn A. Anderson
Summary: Onychomycosis, or fungal nail infection, can cause pain, discomfort, and psychological and social consequences. Current treatments are limited by poor nail penetration or potential toxicity. Plant defensins, such as Ppdef1, have stable structures and potent antifungal activity, making them promising treatments. Ppdef1 shows excellent activity against a range of fungal pathogens, including Trichophyton rubrum, the major cause of onychomycosis.
Article
Dermatology
Chanchan Li, Xinrui Jia, Yawen Bian, Di Qi, Jianbo Wu
Summary: Methylene blue mediated-photodynamic therapy (MB-PDT) has shown to be an effective inhibitor to both spores and hyphae of Trichophyton rubrum in vitro, with spores being more sensitive. The antifungal efficacy of MB-PDT is positively correlated with the concentration of MB and light dose.
Review
Infectious Diseases
Huilin Su, Weiwei Jiang, Paul E. Verweij, Li Li, Junhao Zhu, Jiande Han, Min Zhu, Shuwen Deng
Summary: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has led to the need for the development of new antifungal drugs. In this study, the in vitro antifungal activity of 3 echinocandins against clinical isolates of T. rubrum was evaluated. The results showed that micafungin and anidulafungin exhibited greater potency than caspofungin, suggesting that echinocandins could be potential treatment options for managing recalcitrant dermatophytoses resulting from resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biochemistry & Molecular Biology
Alina Bekmukhametova, Anu Antony, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Mir Muhammad Nasir Uddin, Leonardo Longo, Christian Pedrinazzi, Laurel George, Richard Wuhrer, Simon Myers, Damia Mawad, Jessica Houang, Antonio Lauto
Summary: Rose bengal (RB) solutions combined with a green laser have been effective in treating stubborn nail infections caused by Trichophyton rubrum. However, the RB solution can be diluted or dispersed, making it difficult to reach the infected area. To overcome this issue, RB-encapsulated chitosan nanoparticles have been synthesized, which can effectively penetrate the nail and kill the common pathogens in onychomycosis. These nanoparticles are safe for human cells, making them suitable for clinical use.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Immunology
Caroline Barcelos Costa-Orlandi, Luis R. Martinez, Niura Madalena Bila, Joel M. Friedman, Adam J. Friedman, Maria Jose S. Mendes-Giannini, Joshua D. Nosanchuk
Summary: This study evaluated the anti-T. rubrum biofilm potential of NO-np and compared it to commonly used antifungal drugs. The results showed that NO-np and efinaconazole severely damaged established biofilms, reducing the density and thickness of the biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dermatology
Junichiro Hiruma, Hiromitsu Noguchi, Midori Hase, Yumie Tokuhisa, Tatsuya Shimizu, Takasuke Ogawa, Masataro Hiruma, Kazutoshi Harada, Rui Kano
Summary: Research investigated TRF-resistant Trichophyton interdigitale and T. rubrum strains isolated from Japanese patients, identifying some TRF-resistant strains and revealing genetic mutations in these strains.
JOURNAL OF DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fritz Ka-Ho Ho, Albert Bolhuis, M. Begona Delgado-Charro
Summary: The study tested the use of polymeric films sprayed on the skin for the prevention and treatment of dermatophytosis, showing that the films can both prevent and treat fungal infections, and are generally acceptable for use by healthy volunteers.
Article
Microbiology
Annabel Guttentag, Krishothman Krishnakumar, Nural Cokcetin, Steven Hainsworth, Elizabeth Harry, Dee Carter
Summary: Jarrah honey exhibits potent antifungal activity against dermatophyte species, primarily through high levels of H2O2 production. It inhibits fungal growth effectively, acts mainly on the surface of fungal cells, relies not only on H2O2 but also contains other components that enhance its antifungal activity.
Article
Infectious Diseases
Manuela Gil-Gonzalez, Juan C. Gomez-Velasquez, Natalia Loaiza-Diaz, Sindy Florez-Munoz, Gilma N. Hernandez-Herrera, Ana Cecilia Mesa-Arango
Summary: The study compared cases of onychomycosis caused by Neoscytalidium dimidiatum and Trichophyton rubrum, finding that the clinical characteristics were similar, but N. dimidiatum has lower sensitivity to itraconazole and higher sensitivity to terbinafine.
Article
Microbiology
Marcos E. R. Lopes, Tamires A. Bitencourt, Pablo R. Sanches, Maira P. Martins, Vanderci M. Oliveira, Antonio Rossi, Nilce M. Martinez-Rossi
Summary: Dermatophytes are difficult to treat due to their ability to neutralize the stress caused by antifungal drugs. This resistance is achieved through mechanisms such as drug efflux and biofilm formation. Alternative splicing has also been identified as a mechanism that enhances fungal adaptive responses. This study used RNA-seq data to investigate alternative splicing in genes encoding efflux pumps in the dermatophyte Trichophyton rubrum. The findings suggest that alternative splicing plays a role in drug tolerance and antifungal resistance, particularly in biofilms.
Article
Biochemistry & Molecular Biology
Katya M. Aguilar-Perez, Dora Medina, Roberto Parra-Saldivar, Hafiz M. N. Iqbal
Summary: Nanoliposomes, bilayer vesicles at the nanoscale, have gained popularity for their safety, patient compliance, high entrapment efficiency, and prompt action. In this study, multi-compositional nanoliposomes loaded with clove essential oil (CEO) and tea tree oil (TTO) were characterized to understand their nano-size distribution. The CEO-loaded nanoliposomes showed a maximum entrapment efficacy and exhibited high antifungal activity.
Article
Chemistry, Multidisciplinary
Paola Perugini, Margherita Bonetti, Marta Guerini, Giorgio Musitelli, Pietro Grisoli
Summary: Nail fungal infection has a negative impact on social life, leading to a need for exploring new antifungal treatments. Bovine hoof membranes were used as a model in this study to evaluate the antiadhesive capability of a product.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
T. H. van Essen, L. van Zijl, T. Possemiers, A. A. Mulder, S. J. Zwart, C. -H. Chou, C. C. Lin, H. J. Lai, G. P. M. Luyten, M. J. Tassignon, N. Zakaria, A. El Ghalbzouri, M. J. Jager
Article
Hematology
Maaike Schillemans, Ellie Karampini, Bart L. van den Eshof, Anastasia Gangaev, Menno Hofman, Dorothee van Breevoort, Henriet Meems, Hans Janssen, Aat A. Mulder, Carolina R. Jost, Johanna C. Escher, Ruediger Adam, Tom Carter, Abraham J. Koster, Maartje van den Biggelaar, Jan Voorberg, Ruben Bierings
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Geriatrics & Gerontology
Marjolein Bulk, Walid M. Abdelmoula, Rob J. A. Nabuurs, Linda M. van der Graaf, Coen W. H. Mulders, Aat A. Mulder, Carolina R. Jost, Abraham J. Koster, Mark A. van Buchem, Remco Natte, Jouke Dijkstra, Louise van der Weerd
NEUROBIOLOGY OF AGING
(2018)
Article
Biochemistry & Molecular Biology
Peter M. Quinn, Aat A. Mulder, C. Henrique Alves, Melissa Desrosiers, Sharon I. de Vries, Jan Klooster, Deniz Dalkara, Abraham J. Koster, Carolina R. Jost, Jan Wijnholds
HUMAN MOLECULAR GENETICS
(2019)
Article
Multidisciplinary Sciences
Maarten W. Tuijtel, Aat A. Mulder, Clara C. Posthuma, Barbara van der Hoeven, Abraham J. Koster, Montserrat Barcena, Frank G. A. Faas, Thomas H. Sharp
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Robert A. Berkeley, Lynette R. Steele, Aat A. Mulder, Diana J. M. van den Wollenberg, Timothy J. Kottke, Jill Thompson, Matthew Coffey, Rob C. Hoeben, Richard G. Vile, Alan Melcher, Elizabeth J. Ilett
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Cell & Tissue Engineering
Peter M. Quinn, Thilo M. Buck, Aat A. Mulder, Charlotte Ohonin, C. Henrique Alves, Rogier M. Vos, Monika Bialecka, Tessa van Herwaarden, Elon H. C. van Dijk, Mays Talib, Christian Freund, Harald M. M. Mikkers, Rob C. Hoeben, Marie-Jose Goumans, Camiel J. F. Boon, Abraham J. Koster, Susana M. Chuva de Sousa Lopes, Carolina R. Jost, Jan Wijnholds
Article
Biochemistry & Molecular Biology
C. Henrique Alves, Nanda Boon, Aat A. Mulder, Abraham J. Koster, Carolina R. Jost, Jan Wijnholds
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Clinical Neurology
Gido Gravesteijn, Leon P. Munting, Maurice Overzier, Aat A. Mulder, Ingrid Hegeman, Marc Derieppe, Abraham J. Koster, Sjoerd G. van Duinen, Onno C. Meijer, Annemieke Aartsma-Rus, Louise van der Weerd, Carolina R. Jost, Arn M. J. M. van den Maagdenberg, Julie W. Rutten, Saskia A. J. Lesnik Oberstein
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Gido Gravesteijn, Johannes G. Dauwerse, Maurice Overzier, Gwendolyn Brouwer, Ingrid Hegeman, Aat A. Mulder, Frank Baas, Mark C. Kruit, Gisela M. Terwindt, Sjoerd G. van Duinen, Carolina R. Jost, Annemieke Aartsma-Rus, Saskia A. J. Lesnik Oberstein, Julie W. Rutten
HUMAN MOLECULAR GENETICS
(2020)
Article
Clinical Neurology
Gido Gravesteijn, Remco J. Hack, Aat A. Mulder, Minne N. Cerfontaine, Remco van Doorn, Ingrid M. Hegeman, Carolina R. Jost, Julie W. Rutten, Saskia A. J. Lesnik Oberstein
Summary: CADASIL patients with an EGFr 7-34 variant have significantly less vascular NOTCH3 aggregation than patients with an EGFr 1-6 variant. This may be one of the factors underlying the difference in disease severity between NOTCH3(cys) EGFr 7-34 and EGFr 1-6 variants.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Marcella van Hoolwerff, Alejandro Rodriguez Ruiz, Marga Bouma, H. Eka D. Suchiman, Roman Koning, Carolina R. Jost, Aat A. Mulder, Christian Freund, Farshid Guilak, Yolande F. M. Ramos, Ingrid Meulenbelt
Summary: The study found that a pathogenic mutation in an early-onset osteoarthritis family affected the binding capacity of fibronectin to collagen type II, thus impacting chondrogenic capacity and propensity to an osteoarthritic state. Therefore, restoring or maintaining proper binding between fibronectin and collagen type II is crucial for effective treatment development for osteoarthritis.
Article
Clinical Neurology
Remco J. Hack, Gido Gravesteijn, Minne N. Cerfontaine, Ingrid M. Hegeman, Aat A. Mulder, Saskia A. J. Lesnik Oberstein, Julie W. Rutten
Summary: This study demonstrates that extremely mild small vessel disease (SVD) phenotypes can occur in individuals from Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) pedigrees harboring NOTCH3 EGFr 7-34 variants with normal brain magnetic resonance imaging up to age 58 years. These findings have important implications for CADASIL diagnosis, disease prediction, and counseling of individuals from EGFr 7-34 CADASIL pedigrees.
Article
Multidisciplinary Sciences
Phong D. Nguyen, Iris Gooijers, Giulia Campostrini, Arie O. Verkerk, Hessel Honkoop, Mara Bouwman, Dennis E. M. de Bakker, Tim Koopmans, Aryan Vink, Gerda E. M. Lamers, Avraham Shakked, Jonas Mars, Aat A. Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L. Mummery, Teun P. de Boer, Milena Bellin, Jeroen Bakkers
Summary: Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. The cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, plays a key role in the redifferentiation process.
Article
Cell & Tissue Engineering
Thilo M. Buck, Peter M. J. Quinn, Lucie P. Pellissier, Aat A. Mulder, Aldo Jongejan, Xuefei Lu, Nanda Boon, Danielle Koot, Hind Almushattat, Christiaan H. Arendzen, Rogier M. Vos, Edward J. Bradley, Christian Freund, Harald M. M. Mikkers, Camiel J. F. Boon, Perry D. Moerland, Frank Baas, Abraham J. Koster, Jacques Neefjes, Ilana Berlin, Carolina R. Jost, Jan Wijnholds
Summary: In this study, patient-derived retinal organoids were used to model retinal degenerative diseases caused by CRB1 gene mutations. The results showed various abnormalities in CRB1 patient organoids at the retinal level, including downregulation of CRB1 and NOTCH1 expression, impaired endosome maturation and receptor recycling.