Letter
Gastroenterology & Hepatology
Chao-Ming Hung, Po-Huang Lee, Hui-Ming Lee, Chong-Chi Chiu
Summary: The study revealed a rare case where measles infection led to gastrointestinal cytomegalovirus disease in an immunocompetent infant. Further research and understanding are needed for the diagnosis and treatment of this disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Nevzat Aykut Bayrak, Esra Polat, Furkan Erdogan
Summary: The study found that CMV colitis is a rare but overlooked cause of prolonged diarrhea in children, both immunocompetent and immunocompromised. It may present without ulcer formation during colonoscopy in infants with IBD.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Teresa Da Cunha, George Y. Wu
Summary: HCMV infection is common but mostly asymptomatic. Liver involvement varies significantly, with immunocompromised patients experiencing clinically significant hepatitis, while HCMV hepatitis requiring hospitalization is extremely rare in immunocompetent patients.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryu Uotani, Dai Miyazaki, Yumiko Shimizu, Fumie Ohtani, Tomoko Haruki, Shin-Ichi Sasaki, Ayumi Koyama, Yoshitsugu Inoue, Tatsuo Suzutani
Summary: Ocular CMV infection can cause chronic inflammation and damage to corneal endothelial cells. Induction of specific CTL responses can improve visual prognosis, but improper induction of CTL responses can lead to pathological damage and surgical interventions.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jiyoung Yoon, Junghwan Lee, Dae Sung Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Hwoon-Yong Jung, Suk-Kyun Yang, Jeong-Sik Byeon
Summary: This study investigated the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. It found that most cases occurred in older patients with comorbidities, and the endoscopic features varied with no clear association with clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Florence Dupont, Aurelien Aubry, Jean-Philippe Lanoix, Baptiste Demey
Summary: Cytomegalovirus-associated Gianotti-Crosti syndrome is a rare complication of cytomegalovirus infection that can lead to disruption of anticoagulant treatment and potentially fatal thromboembolic incidents. This article presents a unique case of this syndrome in an immunocompetent adult patient, which has not been reported in the literature before.
Article
Immunology
Jin Li, Jinli Wei, Zhixiang Xu, Chunmei Jiang, Mianhuan Li, Jie Chen, Yanjie Li, Minghui Yang, Yuchen Gu, Fuxiang Wang, Yuelong Shu, Yang Yang, Litao Sun, Yingxia Liu
Summary: This study found that in HAdV infection, the expression of IL-10, M-CSF, MIG, HGF, IL-1 beta, IFN-gamma, and IL-2Ra is closely associated with disease severity, and can predict disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Zhihui Zhang, Xuesong Liu, Ling Sang, Sibei Chen, Zhan Wu, Jierong Zhang, Yining Sun, Yongbo Huang, Yonghao Xu, Weiqun He, Yimin Li, Xiaoqing Liu
Summary: This study investigated the epidemiology and predictors of CMV reactivation in immunocompetent patients requiring mechanical ventilation. It found that BMI, Hb, and sepsis were independent risk factors for CMV reactivation, and could potentially predict CMV reactivation. Adverse prognoses such as longer duration of MV, higher hospitalization expenses, and increased mortality rate were associated with CMV reactivation.
BMC INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Lucie Lefeuvre, Manuel Schibler, Patrice H. Lalive
Summary: This case report presents a patient with Elsberg syndrome caused by primary cytomegalovirus (CMV) infection in an immunocompetent patient. It highlights the importance of considering CMV testing and initiating appropriate antiviral therapy in these patients.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Gastroenterology & Hepatology
Qing-Hua Yang, Xiao-Peng Ma, Dong-Ling Dai, Da-Ming Bai, Yu Zou, Si-Xi Liu, Jian-Ming Song
Summary: The case describes a 9-month-old boy with extensive gastrointestinal CMV disease secondary to measles infection. Treatment with ganciclovir improved the patient's condition. The findings highlight the importance of differential diagnosis, histopathological characteristics, and laboratory tests for gastrointestinal CMV infection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Wujun Jiang, Sainan Chen, Lina Xu, Xueyun Xu, Li Huang, Yuqing Wang, Chuangli Hao
Summary: This study aimed to examine cytomegalovirus (CMV) infection in immunocompetent infants with pertussis and evaluate their clinical characteristics and outcomes. The results showed a high prevalence of CMV reactivation in infants with pertussis, and the presence of CMV in plasma was associated with a higher risk of severe disease and longer hospital stay.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dermatology
H. J. Forbes, K. Bhaskaran, D. Grint, V. H. Hu, S. M. Langan, H. McDonald, C. Morton, L. Smeeth, J. L. Walker, C. Warren-Gash
Summary: Non-PHN complications of herpes zoster were relatively common, which may impact the cost-effectiveness calculations for zoster vaccination. Clinicians should be aware that herpes zoster can lead to various complications, besides postherpetic neuralgia.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Jack P. Wang, Bou-Zenn Lin, Chih-Lin Lin, Kuan-Yang Chen, Tsung-Jung Lin
Summary: This case report describes a rare case of acute CMV hepatitis in an immunocompetent patient. Acute CMV hepatitis was diagnosed based on serological and DNA tests. The patient recovered with symptomatic management and without antiviral therapy.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Infectious Diseases
Kaisei Kamatani, Tsuneaki Kenzaka, Ryu Sugimoto, Ayako Kumabe, Akihito Kitao, Hozuka Akita
Summary: This case report describes an immunocompetent man with multiple microthrombi associated with CMV infection, a rare presentation. The findings suggest that CMV infection should be considered as a possible cause for thrombosis in immunocompetent individuals.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Nadezhda Wall, Alexandra Godlee, Daniel Geh, Charlotte Jones, Sian Faustini, Ruth Harvey, Rebecca Penn, Dimitrios Chanouzas, Peter Nightingale, Matthew O'Shea, Alex Richter, Paul Moss, Adam Cunningham, Lorraine Harper
Summary: Patients with non-dialysis CKD can respond similarly to vaccines as healthy individuals in terms of immune response, despite displaying an immune signature independent of vaccine responsiveness. Prior immunization with PPV23 and CMV infection may influence CKD patients' responsiveness to vaccination.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Hematology
Genghis H. Lopez, Brett Wilson, Robyn M. Turner, Glenda M. Millard, Nicole S. Fraser, Naomi M. Roots, Yew-Wah Liew, Catherine A. Hyland, Robert L. Flower
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2020)
Review
Hematology
Timothy An, Melinda Dean, Robert Flower, Tayla Tatzenko, Hiu Tat Chan, Philip Kiely, Helen M. Faddy
Editorial Material
Hematology
Serena Ekman, Ross T. Barnard, Robert Flower, Alison Gould, Xuan T. Bui
Review
Pediatrics
Shamila Ginige, Robert Flower, Elvina Viennet
Summary: Arboviruses in the perinatal period can have adverse effects on neonates, so preventive strategies are important; current management of perinatal arbovirus infections lacks consensus and further research is needed to better understand the impact.
Article
Hematology
Antoine Lewin, Steven J. Drews, Ryanne Lieshout-Krikke, Christian Erikstrup, Sahar Saeed, Helen Fady, Samra Uzicanin, Brian Custer, Sheila F. O'Brien
Summary: This study evaluated the diversity of assays used by blood operators for anti-SARS-CoV-2 seroprevalence studies, revealing a wide range of commercial and in-house serology assays being utilized. The results suggest that the characteristics of the assay may impact seroprevalence estimates, with some countries reporting seroprevalence rates below 5% as of October 2020.
Review
Hematology
Serena Ekman, Robert Flower, Ross T. Barnard, Alison Gould, Xuan T. Bui
Summary: The article discusses the use of molecular dynamic simulations on existing structures and computational modeling techniques for protein models. Specific examples of computationally derived models of the MNS blood group system and its application in producing antibodies against MNS proteins are also discussed. In silico techniques have limitations, but computer-based predictive models can guide research on blood group proteins, with the potential for greater significance as computational techniques improve.
EXPERT REVIEW OF HEMATOLOGY
(2021)
Article
Virology
Ngoc Minh Hien Phan, Helen M. Faddy, Robert L. Flower, Wayne J. Dimech, Kirsten M. Spann, Eileen Roulis
Summary: This study aimed to characterize the molecular diversity of the HBV small surface gene from HBV-reactive Australian blood donors. The results showed that HBV small surface gene sequences from Australian donors demonstrated a lower level of genetic diversity than those from non-Australian donor population included in the study.
Review
Hematology
Sahar Saeed, Samra Uzicanin, Antoine Lewin, Ryanne Lieshout-Krikke, Helen Faddy, Christian Erikstrup, Carla Osiowy, Clive R. Seed, Whitney R. Steele, Katy Davison, Brian Custer, Sheila F. O'Brien
Summary: The scoping review of SARS-CoV-2 seroprevalence studies among blood donors revealed that most studies showed seroprevalence rates below 10%, and less than one-fifth of the studies were standardized to reflect the general population demographics. Variances in study designs and methodologies were identified as contributing factors to the heterogeneity in seroprevalence rates, alongside differences in community transmission and public health policies.
Article
Infectious Diseases
Timothy White, Gina Mincham, Brian L. Montgomery, Cassie C. Jansen, Xiaodong Huang, Craig R. Williams, Robert L. P. Flower, Helen M. Faddy, Francesca D. Frentiu, Elvina Viennet
Summary: This study estimated the epidemic potential of CHIKV in Australia, finding that major urban centers in Northern Australia could sustain an epidemic. Future trends suggest an increase in epidemic potential towards 2029.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel Lancini, Jaimi Greenslade, Paul Martin, Sandhir Prasad, John Atherton, William Parsonage, Sally Aldous, Martin Than, Louise Cullen
Summary: The presence of atrial fibrillation (AF) can reduce the specificity of cTn testing for the diagnosis of Type 1 myocardial infarction (T1MI) in patients presenting to the emergency department with chest pain. Further studies are needed to determine whether optimized cTn thresholds for patients with AF can improve the evaluation and outcomes.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Lancini, Wei Lian Tan, Kristyan Guppy-Coles, Robert Boots, Sandhir Prasad, John Atherton, Paul Martin
Summary: This study aimed to determine the factors associated with subsequent atrial fibrillation (AF) diagnoses and other adverse outcomes in critical illness associated new onset AF (CI-NOAF) patients. The results showed that AF burden and left atrial size were independently associated with subsequent AF. It was also found that CI-NOAF is often under-recognized and subsequent AF diagnoses are common post-discharge.
Article
Microbiology
Amanda D. Barbosa, Michelle Long, Wenna Lee, Jill M. Austen, Mike Cunneen, Andrew Ratchford, Brian Burns, Prasad Kumarasinghe, Rym Ben-Othman, Tobias R. Kollmann, Cameron R. Stewart, Miles Beaman, Rhys Parry, Roy Hall, Ala Tabor, Justine O'Donovan, Helen M. Faddy, Marjorie Collins, Allen C. Cheng, John Stenos, Stephen Graves, Charlotte L. Oskam, Una M. Ryan, Peter J. Irwin
Summary: There is a lack of data about tick-related illnesses in Australia, especially the Debilitating Symptom Complexes Attributed to Ticks (DSCATT). This research plan aims to investigate the causes, pathophysiology, and clinical outcomes of tick-associated disease in Australia, using prospective data collection, matched control groups, and integrative data analysis. The study includes laboratory analyses, such as metagenomics, to explore potential pathogen transmission during tick bites, as well as multi-omics technology to investigate links between immune responses and disease causations. Psychometric profiling will also be used to examine the influence of psychological attributes on symptom development. The research will contribute to a better understanding of tick-borne diseases and improve diagnostic outcomes and treatment for patients bitten by ticks in Australia.
Article
Cardiac & Cardiovascular Systems
Daniel Lancini, Aveechal Prasad, Liza Thomas, John Atherton, Paul Martin, Sandhir Prasad
Summary: Atrial fibrillation is common after acute myocardial infarction (AMI). Left atrial size has been shown to predict new onset AF, but the optimal metric for risk stratification following AMI is unknown.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Hematology
Daniel Candotti, Steven J. Drews, Helen M. Faddy
Summary: The study aimed to determine the value that blood operators globally place on viral diversity surveillance and assess its impact. A questionnaire was circulated to members of the International Society of Blood Transfusion-transmitted infectious diseases working party. The results showed that 97% of respondents viewed monitoring viral genomic sequences as important, but only 47% were currently doing it. Lack of financial resources and expertise were reported as the main limitations.
Article
Hematology
Eunike C. McGowan, Robert L. Flower, Martina L. Jones, David O. Irving, Ross T. Barnard, Catherine A. Hyland, Stephen M. Mahler, Xuan T. Bui
Summary: This study demonstrates that the discarded blood filter chambers (BFCs) from anti-D donors can serve as a convenient source of Ig-encoding RNA for constructing Ig gene libraries for monoclonal antibody (mAb) isolation and discovery via antibody phage display. The analysis found that BFC aggregates contained lymphocytes as the cellular source of Ig-encoding RNA, leading to successful construction of scFvs and identification of phage clones with specificity to D-positive red blood cells.