Review
Oncology
Isaacson B. Adelani, Oluwakemi A. Rotimi, Emmanuel N. Maduagwu, Solomon O. Rotimi
Summary: Vitamin D deficiency may aid HCC progression and play vital roles in skeletal mineralization and cell cycle regulation. Studies have shown that Vitamin D plays crucial roles in the anticancer effects in HCC and can serve as therapeutic targets. Research advancements have revealed the multifaceted mechanisms of Vitamin D in HCC development.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Meifang Zheng, Runping Gao
Summary: This article reviews the mechanisms and potential therapeutic effects of vitamin D and its analogues in the treatment of pancreatic fibrosis, as well as the relationship between vitamin D deficiency and the risk of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Georgios Markopoulos, Panagiotis Lepetsos, Despina N. Perrea, Dimitrios C. Iliopoulos, Vasileios S. Nikolaou
Summary: Vitamin D may influence osseointegration in bone grafting procedures, as demonstrated by in vitro and animal studies. Clinical observations have also shown positive effects of vitamin D on graft incorporation and bone formation.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Abdullrahman M. Al-Bishari, Bilal A. Al-Shaaobi, Aisha A. Al-Bishari, Mohammed A. Al-Baadani, Liang Yu, Jiating Shen, Lei Cai, Yiding Shen, Zhennan Deng, Peng Gao
Summary: In this study, a multifunctional nanofiber membrane loaded with vitamin D and curcumin was successfully fabricated. It showed potential for enhancing osteoblast proliferation and differentiation, as well as exhibiting superior anti-inflammatory activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Nutrition & Dietetics
Szymon Graczyk, Arkadiusz Grzeczka, Urszula Paslawska, Pawel Kordowitzki
Summary: Atrial fibrillation (AF) is a common and severe arrhythmia that can lead to ischemic stroke or heart failure. Vitamin D deficiency has been suggested as a critical factor in the development of AF, particularly after cardiac surgery. Supplementing with vitamin D has been found to reduce the risk of AF in both pre- and postoperative periods. The underlying mechanisms of how vitamin D affects the heart are not fully understood, but it is believed to act through multiple pathways. Despite the correlation between vitamin D deficiency and AF development, the topic is still widely debated and the results are subject to doubt.
Article
Biochemistry & Molecular Biology
Ralf Herwig, Katharina Erlbacher, Amela Ibrahimagic, Mehtap Kacar, Naime Brajshori, Petrit Beqiri, Joachim Greilberger
Summary: The study demonstrated that the water-soluble vitamin D dimeric compound VitD-dgVDBP promotes macrophage activity while reducing O-2(-) production, and has positive effects on cell apoptosis and immune pathways such as CD16.
Article
Nutrition & Dietetics
Alessandra Manca, Stefano Cosma, Alice Palermiti, Martina Costanzo, Miriam Antonucci, Elisa Delia De Vivo, Alice Ianniello, Fulvio Borella, Andrea Roberto Carosso, Silvia Corcione, Francesco Giuseppe De Rosa, Chiara Benedetto, Antonio D'Avolio, Jessica Cusato
Summary: This is the first study demonstrating the role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Vitamin D-related polymorphisms can affect vitamin D levels in both SARS-CoV-2 positive and negative patients. Vitamin D levels were lower in preterm births among SARS-CoV-2 positive patients.
Review
Nutrition & Dietetics
Christina Starchl, Mario Scherkl, Karin Amrein
Summary: Celiac disease (CD) and autoimmune thyroid diseases (AITD) like Hashimoto's thyroiditis (HT) and Graves' disease (GD) frequently coexist, possibly correlated through gut microbiota, immune system, inflammatory responses, and deficiencies in vitamin D and iron that may impact disease development.
Review
Nutrition & Dietetics
Danilo Tarsio Mota Brito, Luiza Helena Coutinho Ribeiro, Carla Hilario da Cunha Daltro, Roberto de Barros Silva
Summary: Research has shown that vitamin D may have benefits in COVID-19, with low serum levels of vitamin D being associated with disease severity and potentially serving as a possible prophylactic and treatment for infection.
Article
Biochemistry & Molecular Biology
Marie Bicikova, Ludmila Macova, Martin Hill
Summary: Vitamin D plays an important role in immunomodulation, brain development, and functioning. Its potential immunoprotective role in COVID-19 has been discussed. This study found that individuals who took vitamin D had a significantly lower risk of COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
John H. White
Summary: Vitamin D deficiency increases the risk of bacterial and viral infections, and hormonal calcitriol plays an important role in pathogen threat and immune response. Calcitriol regulates gene expression related to innate immunity, including the production of antimicrobial peptides. Recent studies have shown that these peptides are not only effective against bacteria, but also play a significant role in antiviral immunity.
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Article
Immunology
Dirk Lemke, Rainer Johannes Klement, Felix Schweiger, Beatrix Schweiger, Jorg Spitz
Summary: Vitamin D-3 plays an important role in treating autoimmune diseases, and high-dose vitamin D-3 therapy can improve treatment outcomes. Acquired vitamin D resistance may be a plausible pathomechanism for the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Song-Li Pan, Chen-Cui Li, Hong-Wang Cui, Wen-Xian Wang, Chun-Hong Li
Summary: This study aims to evaluate the efficiency of calcium and vitamin D in treating adults diagnosed with osteoporosis caused by corticosteroid therapy. Through systematic literature search and quality assessment, this study will provide additional evidence and practical information for clinicians and policymakers.
Review
Endocrinology & Metabolism
David J. Easty, Christine J. Farr, Bryan T. Hennessy
Summary: Vitamin D is a powerful steroid hormone that has widespread effects on gene expression and biological pathways, but its utility as a therapeutic agent is limited by hypercalcemic effects. Vitamin D superagonists show promise in treatment, but require agonists with high cell-tissue specificity to be successful.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Endocrinology & Metabolism
William B. Grant, Barbara J. Boucher, Pawel Pludowski, Sunil J. Wimalawansa
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Shaun Sabico, Kaiser Wani, William B. B. Grant, Nasser M. M. Al-Daghri
Summary: This interventional study aimed to investigate the effects of correcting vitamin D status on the 10-year risk of Atherosclerotic Cardiovascular Disease (ASCVD) in deficient Arab adults. The study found that while only a small proportion of participants achieved optimal vitamin D levels, there was a modest improvement in HDL cholesterol and 10-year ASCVD risk scores for both genders. The improvement was slightly more pronounced in males than females.
Article
Nutrition & Dietetics
Fatme Al Anouti, William B. Grant, Justin Thomas, Sharifa AlBlooshi, Spyridon Karras
Summary: Vitamin D insufficiency affects half of the global population, and its deficiency is associated with anxiety symptoms. Sun avoidance behaviors are strongly correlated with an elevated risk of generalized anxiety disorder among adult females in the United Arab Emirates.
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Letter
Oncology
William B. Grant
INTERNATIONAL JOURNAL OF CANCER
(2023)
Letter
Medicine, General & Internal
William B. B. Grant, Barbara J. J. Boucher
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Nutrition & Dietetics
William B. Grant, Barbara M. van Amerongen, Barbara J. Boucher
Summary: For nearly a century, researchers have found an association between periodontal disease and other adverse health outcomes, but experiments have not supported the hypothesis that PD causes these outcomes. Instead, the association is due to shared risk factors such as smoking, diet, obesity, physical activity, and vitamin D levels.
Editorial Material
Nutrition & Dietetics
Ronan Lordan, William B. Grant
Article
Nutrition & Dietetics
Beth S. S. Sanford, Jennifer L. L. Aliano, Courtney S. S. Omary, Sharon L. L. McDonnell, Samantha M. M. Kimball, William B. B. Grant
Summary: Preventable vitamin D deficiency is a global health concern. A vitamin D toolkit was developed to increase healthcare professionals' knowledge and confidence regarding vitamin D and aid in translating evidence into practice. The completion of the toolkit significantly increased participants' knowledge and confidence levels.
Review
Nutrition & Dietetics
Fatheia N. N. Hamza, Sarah Daher, Hana M. A. Fakhoury, William B. B. Grant, Peter R. R. Kvietys, Khaled Al-Kattan
Summary: Vitamin D plays a crucial role in modulating the innate immune response by interacting with its intracellular receptor, VDR. It contributes to the regulation of intestinal and respiratory microbiota and the modulation of components of the innate immune system. Vitamin D/VDR signaling mounts an antimicrobial response through the transduction of microbial signals and the production of antimicrobial peptides. Vitamin D supplementation may have potentially beneficial effects on diseases such as inflammatory bowel disease and acute respiratory distress syndrome.
Review
Biochemistry & Molecular Biology
William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Hana M. A. Fakhoury, Meis Moukayed, Stefan Pilz, Nasser M. Al-Daghri
Summary: Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases, and this study aims to estimate the expected reduction in incidence and mortality rates of vitamin D-related diseases in Saudi Arabia and the United Arab Emirates.
Article
Nutrition & Dietetics
Hana M. A. Fakhoury, Tarek Ziad Arabi, Hani Tamim, Rene F. Chun, William B. Grant, Martin Hewison, Fatme Alanouti, Stefan Pilz, Cedric Annweiler, Georgios Tzimagiorgis, Costas Haitoglou, Spyridon N. Karras
Summary: Sufficient vitamin D status is crucial for successful pregnancy and fetal development. This study found positive associations between maternal and neonatal vitamin D status, with the exception of bioavailable maternal form. There were no significant interactions between maternal and neonatal vitamin D parameters and other calciotropic or anthropometric outcomes.
BRITISH JOURNAL OF NUTRITION
(2023)
Editorial Material
Nutrition & Dietetics
William B. B. Grant
Review
Rheumatology
Maciej K. K. Stawicki, Pawel Abramowicz, Gabriela Sokolowska, Sebastian Wolejszo, William B. B. Grant, Jerzy Konstantynowicz
Summary: Vitamin D plays a role in regulating immunity and autoimmune processes, and low levels have been found in patients with inflammatory and autoimmune rheumatic conditions. However, there is currently no definitive evidence for the preventive or therapeutic effect of vitamin D supplementation in juvenile rheumatic diseases (JRDs). More well-designed studies are needed to determine the potential significance of vitamin D in JRDs treatment.
RHEUMATOLOGY INTERNATIONAL
(2023)
Letter
Obstetrics & Gynecology
William B. Grant, Fatme Al Anouti, Barbara J. Boucher
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)