Article
Nanoscience & Nanotechnology
Yazhong Wei, Minfang Zhu, Saiqi Li, Ting Hong, Xiaoyu Guo, Yongyong Li, Yiqiong Liu, Xumin Hou, Bin He
Summary: PDA@M, a nanoplatform, can target infarcted myocardium to provide antioxidative and antipyroptosis functions for myocardial protection against MI/RI-induced oxidative stress. The results demonstrate that PDA@M significantly reduces infarct size and improves cardiac function post-MI/RI.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Jing Mu, Chunxiao Li, Shi Yu, Guoyong Liu, Jianhua Zou, Dong-Yang Zhang, Chao Jiang, Xiuli Wang, Liangcan He, Peng Huang, Yuxin Yin, Xiaoyuan Chen
Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.
NATURE COMMUNICATIONS
(2022)
Review
Physiology
Bowen Xu, Chunxiao Wang, Hongping Chen, Lihui Zhang, Lei Gong, Lin Zhong, Jun Yang
Summary: Ischemia/reperfusion (I/R) injury is a common clinical problem that can lead to cell damage and death. MG53, a protein highly expressed in mouse skeletal and cardiac muscle, has been found to repair cell membrane damage and protect multiple oxygen-dependent organs from I/R injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dou Huang, Changwei Chen, Yunxia Zuo, Lei Du, Ting Liu, Geoffrey W. Abbott, Zhaoyang Hu
Summary: This study found that RLIPost reduces pulmonary damage induced by ischemia-reperfusion in both non-diabetic and diabetic rats. The protective mechanism in non-diabetic rats is associated with STAT-3, while in diabetic rats it is independent of STAT-3.
Article
Medicine, Research & Experimental
Xiaoyang Lan, Yumin Xu
Summary: Lidocaine, a local anesthetic, has been shown to exhibit neuroprotective effects against neuronal damage induced by OGD/R through the activation of the Wnt/beta-catenin signaling pathway, leading to reduced apoptosis in cortical neurons.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Minglang Gao, Ziyao Zhang, Kai Lai, Yu Deng, Chuanbing Zhao, Zilong Lu, Qing Geng
Summary: Puerarin has protective effects on ischemia-reperfusion injuries of organs such as the heart and brain, achieved through vasodilation and anti-free radical generation. With further research, puerarin is expected to be an effective drug for the treatment of ischemia-reperfusion injuries.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Weijie Xie, Xinyue Wang, Tianbao Xiao, Yibo Cao, Yumei Wu, Dongsheng Yang, Song Zhang
Summary: Ginseng Rb1 has significant neuroprotective effects on cerebral ischemic injury, with mechanisms involving antioxidant, anti-inflammatory, and antiapoptotic activities, as well as inhibition of excitotoxicity and Ca2(+) influx, preservation of blood-brain barrier integrity, and maintenance of energy metabolism. As a result, GRb1 has the potential to be a candidate drug for treating ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Young Sook Lee, Hadi Javan, Jo-Anna Reems, Ling Li, Jessica Lusty, Christine Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Summary: Cell-free human amniotic fluid, a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation, significantly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion, suggesting its potential as a cardioprotective adjunct.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhen Qiu, Hao Ming, Yi Zhang, Yanli Yu, Shaoqing Lei, Zhong-yuan Xia
Summary: Histone deacetylase 3 (HDAC3) and silent information regulator 1 (SIRT1) play important roles in regulating metabolic pathways and are involved in diabetes and myocardial ischemia/reperfusion (IR) injury. The study found that the disordered HDAC3/SIRT1 circuit exacerbates myocardial IR injury in diabetic rats by affecting Bmal1-mediated autophagy. Targeting HDAC3/SIRT1 to activate autophagy may be a novel strategy to alleviate myocardial IR injury in diabetes.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zihui Zhang, Wenhua Jiang, Chan Zhang, Yue Yin, Nan Mu, Yishi Wang, Lu Yu, Heng Ma
Summary: Through a multi-level study from molecule to animal model, these findings uncover the key role of frataxin in inhibiting cardiomyocyte ferroptosis and provide new strategies and perspectives for the treatment of myocardial I/R injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Ji Yuan, Xiaoyang Fu
Summary: The study revealed that by increasing miR-21 expression or inhibiting SPP1, EI can improve cardiac function and alleviate oxidative stress, myocardial fibrosis, inflammatory response, and cardiomyocyte apoptosis caused by myocardial I/R injury. Inhibition of miR-21, however, suppresses the therapeutic effects of EI.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Mei Li, Zhi Zheng
Summary: Parecoxib sodium attenuates intestinal injury induced by ischemia reperfusion by increasing antioxidant levels, suppressing oxidative damage, reducing inflammation, and promoting cell survival. It also improves the survival rate of rats post-reperfusion by inhibiting apoptosis and inflammation caused by I/R.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Behzad Lotfi, Yasin Bagheri, Abdollah Abdollahpour, Elham Ahmadian, Samira Matin, Amirhossein Firouzfar, Sepideh Zununi Vahed, Fateme Khajepour
Summary: This study aimed to evaluate the effect of Eprosartan, an AT-1 antagonist, on kidney I/R injury in rats. Results showed that Eprosartan significantly improved kidney function and increased antioxidant markers. Eprosartan exhibited anti-inflammatory activity by downregulating NF-kappa B and pro-inflammatory factors. It also prevented I/R-induced changes in apoptotic parameters. Additionally, Eprosartan + I/R rats showed higher levels of Sirtuin 1. In conclusion, Eprosartan has nephroprotective effects against I/R-induced kidney damage in rats by reducing oxidative stress, inflammation, and apoptosis, as well as increasing Sirtuin 1 levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liming Yu, Feijiang Li, Guolong Zhao, Yang Yang, Zhenxiao Jin, Mengen Zhai, Wenjun Yu, Lin Zhao, Wensheng Chen, Weixun Duan, Shiqiang Yu
Article
Cell Biology
Hongliang Liang, Weixun Duan, Huiyuan Hou, Wei Yi, Jinzhou Zhang, Zhenxiao Jin, Mengen Zhai, Shiqiang Yu, Jincheng Liu, Dinghua Yi
CELL AND TISSUE RESEARCH
(2015)
Article
Endocrinology & Metabolism
Liming Yu, Hongliang Liang, Zhihong Lu, Guolong Zhao, Mengen Zhai, Yang Yang, Jian Yang, Dinghua Yi, Wensheng Chen, Xiaowu Wang, Weixun Duan, Zhenxiao Jin, Shiqiang Yu
JOURNAL OF PINEAL RESEARCH
(2015)
Article
Endocrinology & Metabolism
Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu
JOURNAL OF PINEAL RESEARCH
(2015)
Article
Chemistry, Multidisciplinary
Guo-long Zhao, Li-ming Yu, Wen-li Gao, Wei-xun Duan, Bo Jiang, Xu-dong Liu, Bin Zhang, Zhen-hua Liu, Meng-en Zhai, Zhen-xiao Jin, Shi-qiang Yu, Yun Wang
ACTA PHARMACOLOGICA SINICA
(2016)
Article
Pharmacology & Pharmacy
Yang Yang, Song Zhang, Chongxi Fan, Wei Yi, Shuai Jiang, Shouyi Di, Zhiqiang Ma, Wei Hu, Chao Deng, Jianjun Lv, Tian Li, Yongzhan Nie, Zhenxiao Jin
EXPERT OPINION ON THERAPEUTIC TARGETS
(2016)
Article
Endocrinology & Metabolism
Yang Yang, Chongxi Fan, Chao Deng, Lin Zhao, Wei Hu, Shouyin Di, Zhiqiang Ma, Yu Zhang, Zhigang Qin, Zhenxiao Jin, Xiaolong Yan, Shuai Jiang, Yang Sun, Wei Yi
JOURNAL OF PINEAL RESEARCH
(2016)
Article
Endocrinology & Metabolism
Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J. Reiter, Weixun Duan, Shiqiang Yu
JOURNAL OF PINEAL RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Jian Yang, Zhenxiao Jin, Hailong Zhu, Shiqiang Yu, Guocheng Sun
JOURNAL OF CARDIAC SURGERY
(2014)
Article
Endocrinology & Metabolism
Liming Yu, Yang Sun, Liang Cheng, Zhenxiao Jin, Yang Yang, Mengen Zhai, Haifeng Pei, Xiaowu Wang, Haifeng Zhang, Qiang Meng, Yu Zhang, Shiqiang Yu, Weixun Duan
JOURNAL OF PINEAL RESEARCH
(2014)
Article
Oncology
Zhenxing Liang, Yang Yang, Haibin Wang, Wei Yi, Xiaolong Yan, Juanjuan Yan, Yue Li, Yingtong Feng, Shiqiang Yu, Jian Yang, Zhenxiao Jin, Weixun Duan, Wensheng Chen
MOLECULAR CANCER THERAPEUTICS
(2014)
Article
Cell Biology
Ting Ji, Xiaolu Zhang, Zhenlong Xin, Baoping Xu, Zhenxiao Jin, Jiawei Wu, Wei Hu, Yang Yang
AGEING RESEARCH REVIEWS
(2020)
Article
Medicine, Research & Experimental
Kai Ren, Weixun Duan, Linhe Lu, Bo Yu, Tao Chen, Zhenxiao Jin, Yimin Zhao, Dinghua Yi, Shiqiang Yu, Xufeng Wei
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Medicine, General & Internal
Chen Yang, Peng Hou, Dongxu Wang, Zhenguo Wang, Weixun Duan, Jincheng Liu, Shiqiang Yu, Feng Fu, Zhenxiao Jin
Summary: The correlation between serum myoglobin and acute kidney injury in patients who underwent total aortic arch replacement with frozen elephant trunk implantation was investigated. It was found that elevated serum myoglobin levels were associated with increased risk of severe acute kidney injury. Serum myoglobin could improve the risk classification of postoperative acute kidney injury.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Bing Zhang, Lei Shi, Yanzhen Tan, Yenong Zhou, Jun Cui, Yujie Song, Yingying Liu, Miao Zhang, Weixun Duan, Zhenxiao Jin, Jincheng Liu, Dinghua Yi, Yang Sun, Wei Yi
Summary: Pathological cardiac hypertrophy can lead to heart failure. This study explored the role of FoxO6, a key transcription factor, in cardiac hypertrophy. The results showed that FoxO6 deficiency attenuated cardiac remodeling and dysfunction, while FoxO6 overexpression aggravated cardiomyopathy and heart dysfunction. Further studies identified Kif15 as a downstream molecule of FoxO6 and found that its inhibition can attenuate the detrimental effects of FoxO6 overexpression. These findings provide new therapeutic targets for heart failure.
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
