期刊
MEDICAL HYPOTHESES
卷 77, 期 5, 页码 807-811出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2011.07.042
关键词
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资金
- National Natural Science Foundation of China [30630058, 30571725, 30801027]
- Chinese Academy of Science [[2009]236]
- Fundamental Research Funds for the Central Universities [xjj20100032]
- National Innovation Experiment Program for University Students [08120018]
Selenium participates the formation of selenoprotein as the form of selenocysteine, the active-site residue essential for protein catalytic activity. It has been proved that selenium deficiency leads to the abnormality of selenoprotein biosynthesis, which may lead to disorders of brain, skeleton development and cartilage chondrocyte differentiation. The production of selenoproteins is regulated by selenocysteine insertion sequence (SECIS) and several trans-acting factors in eukaryotic cells. However, the mechanism of posttranscriptional modification of selenoproteins biosynthesis seldom needs to be elucidated. Recent evidence indicates that miRNAs are key points in the process of endochondral ossification. The hypothesis is that the expression of key selenoproteins may regulate directly or indirectly via trans-acting factors by miRNAs during skeleton development. (C) 2011 Elsevier Ltd. All rights reserved.
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