Article
Biochemistry & Molecular Biology
Nancy Y. A. Sey, Benxia Hu, Marina Iskhakova, Sool Lee, Huaigu Sun, Neda Shokrian, Gabriella Ben Hutta, Jesse A. Marks, Bryan C. Quach, Eric O. Johnson, Dana B. Hancock, Schahram Akbarian, Hyejung Won
Summary: Cigarette smoking and alcohol use are widespread substance behaviors that have significant public health implications. Genome-wide association studies have identified genetic variants associated with these behaviors, but their target genes and neurobiological mechanisms are largely unknown. This study uses chromosomal conformation mappings to investigate the functional impact of these genetic variants and identifies key pathways and relevant cell types involved in cigarette smoking, alcohol use, and addiction. The findings provide insights into the neurobiological mechanisms underlying these behaviors and highlight the importance of dopaminergic pathways in addiction. The study also reveals pleiotropic genes that may reveal shared neurobiological mechanisms of addiction.
MOLECULAR PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Catherine A. Dennen, Kenneth Blum, Abdalla Bowirrat, Panayotis K. Thanos, Igor Elman, Mauro Ceccanti, Rajendra D. Badgaiyan, Thomas McLaughlin, Ashim Gupta, Anish Bajaj, David Baron, B. William Downs, Debasis Bagchi, Mark S. Gold
Summary: This case series presents a novel genetic addiction risk score (GARS) that shows a high prevalence of polymorphic risk alleles in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues. The study highlights the impact of genetic information on reducing stigma and guilt in a struggling family. The future plan is to introduce a DNA-guided pro-dopamine regulator to aid in recovery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Marieke E. van der Schaaf, Katharina Schmidt, Jaspreet Kaur, Matthias Gamer, Katja Wiech, Katarina Forkmann, Ulrike Bingel
Summary: This study compared the acquisition and extinction of conditioned stimuli in a capsaicin heat pain paradigm in healthy human participants. The results demonstrated a preponderance to acquire aversive rather than appetitive cues, which may initially have a protective function but eventually contribute to the maintenance of chronic pain.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Manny D. Bacolod, Francis Barany
Summary: This study utilized integrated bioinformatic and statistical reanalysis of publicly available genomic datasets to identify molecular pathways and biomarkers relevant to metastatic prostate cancer progression. The transition from primary prostate cancer to mPrCa is characterized by upregulation of processes associated with DNA replication, metastasis, and events regulated by the serine/threonine kinase PLK1. Over-expressed genes identified may be potential targets for therapeutic interventions and minimally invasive diagnostics for mPrCa.
Article
Immunology
Yiwei Zhang, Zhengwei Duan, Yonghao Guan, Tianyang Xu, Yuesong Fu, Guodong Li
Summary: This study aims to analyze the pathogenesis shared by osteoarthritis (OA) and COVID-19 and identify drugs for the treatment of SARS-CoV-2-infected OA patients. Through data analysis and single-cell analysis, three key genes possibly involved in the development of OA and COVID-19 were identified, and potential drugs for the treatment of OA patients were discovered.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychology, Clinical
Michelle G. G. Craske, Alicia E. E. Meuret, Aileen Echiverri-Cohen, David Rosenfield, Thomas Ritz
Summary: This study aimed to determine whether a novel psychosocial treatment for positive affect improves clinical status and reward sensitivity more than a form of cognitive behavioral therapy that targets negative affect. The results showed that positive affect treatment achieved superior improvements in clinical status and reward sensitivity compared to negative affect treatment, and improvements in reward sensitivity were correlated with improvements in clinical status.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Adrian Ujin Yap, Min-Juan Zhang, Jie Lei, Kai -Yuan Fu
Summary: This clinical study aimed to determine the diagnostic accuracy of the short-form Fonseca Anamnestic Index (SFAI) in relation to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD).
JOURNAL OF PROSTHETIC DENTISTRY
(2022)
Article
Multidisciplinary Sciences
Rosany O. Lisboa, Raymond F. Sekula, Mariana Bezamat, Kathleen Deeley, Luiz Carlos Santana-da-Silva, Alexandre R. Vieira
Summary: Pain is a subjective experience influenced by various unique factors. Understanding individual differences is crucial for personalized and efficient pain management. Through association studies, we found that variants in pain-related genes are associated with asthma and oral phenotypes.
Article
Genetics & Heredity
Wentao Wu, Daning Li, Xiaojie Feng, Fanfan Zhao, Chengzhuo Li, Shuai Zheng, Jun Lyu
Summary: The study analyzed the expression profiles of seven genes in the TXNRD and GPX families, revealing their correlations with patient survival, immune-cell subtypes, tumor microenvironment, and drug sensitivity. The expression levels of these genes were found to be related to the overall survival of patients, with some genes associated with poor prognoses and others with good or poor prognoses depending on the type of cancer. Additionally, the genes were correlated to varying degrees with immune-cell subtypes, mechanistic cell infiltration, and tumor cell stemness, and some genes may exert dual effects in tumor mutagenesis and drug development.
BMC MEDICAL GENOMICS
(2021)
Article
Medicine, General & Internal
Yong -tong Chen, Xuan-hao Xu, Ling Lin, Shuai Tian, Gui-fu Wu
Summary: This study investigated the clinical implication of cuproptosis-related genes (CRGs) in atherosclerosis. Functional annotation and validation of selected genes were performed, and a signature of CRGs for diagnostic validation was constructed. The results suggest that the cuproptosis-related gene signature could serve as a potential diagnostic biomarker for atherosclerosis and may offer novel insights into the treatment of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ayse Toraman, Emine Toraman, Mustafa Ozkaraca, Harun Budak
Summary: This study found that rats with paclitaxel-induced neuropathic pain-like behavior showed increased periodontal attachment loss and inflammatory cell infiltration, along with significantly higher HCN2 expression and lower KCNS1 expression. These findings may be helpful in developing new approaches to alleviate pain and maintain periodontal health in patients suffering from orofacial pain.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pediatrics
Alondra Valdez, Kathryn E. Smith, Tyler B. Mason
Summary: This study examines the prospective associations between impulsivity and reward sensitivity traits and body mass index z-score (BMI-z) in children with and without binge-eating disorder (BED). The findings indicate that negative urgency and low positive urgency predict increased BMI-z in children with BED, highlighting the importance of addressing emotional impulsivity in obesity prevention interventions for these children.
Article
Genetics & Heredity
Yi-Yuan Qu, Rong-Yan Guo, Meng-Ling Luo, Quan Zhou
Summary: This study revealed that SLC39 family genes play significant roles in cancer progression, immune infiltration, and drug sensitivity in multiple cancers, providing insights into potential pan-cancer targets of SLC39 family genes.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Shizhe Yu, Haoren Wang, Jie Gao, Long Liu, Xiaoyan Sun, Zhihui Wang, Peihao Wen, Xiaoyi Shi, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: This study developed a prognostic model for liver cancer patients using an adaptive daisy model (ADaM) and identified a 25-gene signature. The high-risk group identified by the model exhibited poorer stemness index and shorter overall survival time. Functional enrichment analysis revealed the importance of metabolic rearrangements and serine/threonine kinase activity.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
M. Tada, H. Matano, H. Azuma, K- Kano, S. Maeda, S. Fujino, N. Yamada, H. Uzui, H. Tada, K. Maeno, Y. Shimada, H. Yoshida, M. Ando, T. Ichihashi, Y. Murakami, Y. Homma, H. Funakoshi, K. Obunai, A. Matsushima, N. Ohte, A. Takeuchi, Y. Takada, S. Matsukubo, H. Ando, Y. Furukawa, A. Kuriyama, T. Fujisawa, A. R. Chapman, N. L. Mills, H. Hayashi, N. Watanabe, T. A. Furukawa
Summary: This study aimed to evaluate diagnostic algorithms for myocardial infarction using a high-sensitivity cardiac troponin I (hs-cTnI) assay. A total of 437 patients with suspected myocardial infarction were enrolled from emergency departments, and the hs-cTnI algorithms, especially the High-STEACS pathway, demonstrated excellent safety performance for the early diagnosis of myocardial infarction and offered the greatest improvement in efficiency.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Kenneth Blum, Peter K. Thanos, Rajendra D. Badgaiyan, Marcelo Febo, Marlene Oscar-Berman, James Fratantonio, Zsolt Demotrovics, Mark S. Gold
EXPERT OPINION ON BIOLOGICAL THERAPY
(2015)
Article
Pharmacology & Pharmacy
Clifford M. Knapp, Domenic A. Ciraulo, Ofra Sarid-Segal, Mark A. Richardson, Eric Devine, Chris C. Streeter, Marlene Oscar-Berman, Caitlin Surprise, Laurie Colaneri, Meghan Putnam, Megan Waters, Courtney Richambault
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2015)
Article
Psychiatry
Thomas Mclaughlin, Kenneth Blum, Marlene Oscar-Berman, Marcelo Febo, Gozde Agan, James L. Fratantonio, Thomas Simpatico, Mark S. Gold
JOURNAL OF BEHAVIORAL ADDICTIONS
(2015)
Article
Multidisciplinary Sciences
Kayle S. Sawyer, Alan Poey, Susan Mosher Ruiz, Ksenija Marinkovic, Marlene Oscar-Berman
Article
Substance Abuse
Kayle S. Sawyer, Marlene Oscar-Berman, Susan Mosher Ruiz, Daniel A. Galvez, Nikos Makris, Gordon J. Harris, Eve M. Valera
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Neuroimaging
Johanna Seitz, Kayle S. Sawyer, George Papadimitriou, Marlene Oscar-Berman, Isaac Ng, Antoni Kubicki, Palig Mouradian, Susan M. Ruiz, Marek Kubicki, Gordon J. Harris, Nikos Makris
BRAIN IMAGING AND BEHAVIOR
(2017)
Article
Neurosciences
Kenneth Blum, Thomas Simpatico, Marcelo Febo, Chris Rodriquez, Kristina Dushaj, Mona Li, Eric R. Braverman, Zsolt Demetrovics, Marlene Oscar-Berman, Rajendra D. Badgaiyan
MOLECULAR NEUROBIOLOGY
(2017)
Article
Clinical Neurology
Kayle S. Sawyer, Marlene Oscar-Berrnan, Olivier J. Barthelemy, George M. Papadimitriou, Gordon J. Harris, Nikos Malais
PSYCHIATRY RESEARCH-NEUROIMAGING
(2017)
Article
Substance Abuse
Kenneth Blum, David Han, Edward J. Modestino, Scott Saunders, A. Kennison Roy, W. Jacobs, Darryl S. Inaba, David Baron, Marlene Oscar-Berman, Mary Hauser, Rajendra D. Badgaiyan, David E. Smith, John Femino, Mark S. Gold
SUBSTANCE USE & MISUSE
(2018)
Article
Biology
Kayle S. Sawyer, Nasim Maleki, Trinity Urban, Ksenija Marinkovic, Steven Karson, Susan M. Ruiz, Gordon J. Harris, Marlene Oscar-Berman
Article
Multidisciplinary Sciences
Kayle S. Sawyer, Noor Adra, Daniel M. Salz, Maaria Kemppainen, Susan M. Ruiz, Gordon J. Harris, Marlene Oscar-Berman
Article
Multidisciplinary Sciences
Marlene Oscar-Berman, Susan Mosher Ruiz, Ksenija Marinkovic, Mary M. Valmas, Gordon J. Harris, Kayle S. Sawyer
Summary: Research on Alcohol Use Disorder (AUD) involving women has revealed that differences in gender can lead to unique patterns of cognitive, emotional, and neuropsychological dysfunction. Functional magnetic resonance imaging (fMRI) was used to study abstinent individuals with a history of AUD, and the results showed that women in the AUD group had lower activation compared to women in the non-AUD control group when processing emotional faces, while men in the AUD group showed higher activation compared to men in the non-AUD control group, indicating gender differences in neural responses to facial expressions of emotion.
Article
Neurosciences
Nasim Maleki, Marlene Oscar-Berman
Article
Substance Abuse
Susan Mosher Ruiz, Marlene Oscar-Berman, Maaria I. Kemppainen, Mary M. Valmas, Kayle S. Sawyer
ALCOHOL AND ALCOHOLISM
(2017)
Review
Behavioral Sciences
Benjamin L. Thompson, Marlene Oscar-Berman, Gary B. Kaplan
Summary: Opioid Use Disorder (OUD) is a chronic condition with significant morbidity and mortality even with treatment. Neuroplasticity plays a key role in OUD development, with alterations in dopaminergic and glutamatergic pathways potentially leading to behavioral symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)