Innovative strategies for tissue engineered skin based on multiple growth factors gene transfection

Tissue engineering combines the principles of cell biology, engineering and materials science to develop three-dimensional tissues to replace or restore tissue function. Tissue engineered skin (TE-skin) is one of most advanced tissue constructs. However, much clinical providence demonstrates the TE-skin may not be viewed as the equal of skin grafts, the contributions to accelerate the closure of wound were come mainly from various growth factor. These growth factors respond to its environment to bring about the desired effect. In our hypothesis, this three-dimensional skin substitute could be genetically modified with various growth factor and transplanted in order to deliver therapeutic proteins locally and systemically for the treatment of trauma. The likelihood of transgened TE-skin plays function as a pharmacological agent suggests a wide range of therapeutic applications. In future, the TE-skin could be design as gene delivery to enhance potential capacity for treatment of burns, chronic wounds and even systemic diseases. (C) 2009 Elsevier Ltd. All rights reserved.