Article
Biotechnology & Applied Microbiology
Xiongcheng Xu, Ziqin Chen, Long Xiao, Yanmei Xu, Nianqi Xiao, Weiqiu Jin, Yuling Chen, Yanfen Li, Kai Luo
Summary: This study aimed to investigate the effects of nanosilicate-incorporated PCL (PCL/LAP) nanofibrous membranes on periodontal ligament cells (PDLCs) in vitro and periodontal regeneration in vivo. The results showed that the PCL/LAP nanofibrous membrane exhibited good biocompatibility and bioactivity, enhanced the proliferation and osteogenic differentiation of PDLCs, and promoted periodontal regeneration by orchestrating the immunomodulatory effects of PDLCs. Therefore, the PCL/LAP nanofibrous membrane has the potential to be a promising biomaterial for periodontal regeneration therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Liya Ma, Nanquan Rao, Hui Jiang, Yuzhe Dai, Songtao Yang, Hefeng Yang, Jiangtian Hu
Summary: This study investigates the potential of DFSCs-sEVs in regenerating damaged periodontal tissue. The results show that DFSCs-sEVs promoted the proliferation, migration, and osteogenic differentiation of PDLSCs, potentially through the activation of the p38 MAPK signaling pathway. DFSCs-sEVs provide a novel strategy for periodontal regeneration.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Dentistry, Oral Surgery & Medicine
Sinan Mert, Hanna Malyaran, Rogerio B. Craveiro, Michael Wolf, Ali Modabber, Willi Jahnen-Dechent, Sabine Neuss
Summary: Clinical experience suggests that wounds in the maxilla heal faster and more efficiently compared with the mandible. This study aimed to investigate whether differences in the proliferation and differentiation of periodontal ligament stem cells (PDLSC) from the maxilla and mandible contribute to this discrepancy. The results showed that maxillary PDLSC exhibited higher proliferation and differentiation potential compared to mandibular PDLSC, indicating a possible cell-based explanation for the different healing efficacy in the maxilla and mandible.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Engineering, Biomedical
Chen Zong, Wannes Van Holm, Annelies Bronckaers, Zuodong Zhao, Stevan Cokic, Merve Kubra Aktan, Ana Belen Castro, Bart Van Meerbeek, Annabel Braem, Guy Willems, Maria Cadenas de Llano-Perula
Summary: The study shows that pretreatment of human periodontal ligament stem cells (hPDLSCs) with gold nanocomplexes (AuNCs) and transplantation in a collagen hydrogel scaffold can effectively protect alveolar bone from resorption and promote bone regeneration, suggesting a promising strategy for bone defect treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yongxi Liang, Ajay Shakya, Xiaohua Liu
Summary: This study designed and fabricated a bioinspired tubular 3D matrix to guide the migration and growth of human periodontal ligament stem cells (PDLSCs) and form aligned fiber bundles. The tubular matrix controlled cell migration and alignment through inhibiting osteogenic differentiation. Mechanism study revealed involvement of the Yap1/Twist1 signaling pathway.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Shuangshuang Ren, Yi Zhou, Kai Zheng, Xuanwen Xu, Jie Yang, Xiaoyu Wang, Leiying Miao, Hui Wei, Yan Xu
Summary: This study investigated the effect of cerium oxide nanoparticles (CeO2 NPs) on the behavior and function of human periodontal ligament stem cells (hPDLSCs). The results showed that CeO2 NPs had good biocompatibility and promoted cell proliferation. Furthermore, the CeO2 NPs were able to promote osteogenic differentiation of hPDLSCs. The researchers also fabricated fibrous membranes containing CeO2 NPs using electrospinning, which improved mechanical properties and released the nanoparticles. In vivo experiments in rat cranial defect models further demonstrated that the nanofibrous membranes with CeO2 NPs accelerated new bone formation.
BIOACTIVE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Yun Lu, Liru Zhao, Jiaqi Mao, Wen Liu, Wensheng Ma, Bingjiao Zhao
Summary: Periodontitis, a common infectious disease worldwide, leads to destruction of the periodontal ligament-alveolar bone complex. Communication between periodontal ligament stem cells (PDLSCs) and bone marrow mesenchymal stem cells (BMMSCs) is considered a major contributor to osteogenesis. PDLSC-derived extracellular vesicles (P-EVs) have shown great potential for bone regeneration, but the secretion and uptake mechanisms remain elusive.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Heejin Kim, Ko Eun Lee, Yong Kwon Chae, Ok Hyung Nam, Mi Sun Kim, Ji-Hyun Jang, Sung Chul Choi, Hyo-Seol Lee
Summary: This study compared and evaluated the characteristics of 3D cultured periodontal ligament stem cells derived from permanent teeth (pPDLSCs) and supernumerary teeth (sPDLSCs), and assessed their differences in morphology, size, cell viability, and multilineage differentiation. The results showed that both pPDLSCs and sPDLSCs exhibited osteogenic, chondrogenic, and adipogenic differentiation capacities in 3D culture.
APPLIED SCIENCES-BASEL
(2023)
Article
Cell & Tissue Engineering
Li Wang, Hong Liang, Bingjing Sun, Jing Mi, Xianqin Tong, Yuhui Wang, Meihua Chen, Liming Yu, Jie Pan, Shangfeng Liu, Yan-Jun Liu, Yuehua Liu
Summary: Appropriate mechanical force application activates TRPC6 in PDLSCs, contributing to periodontal tissue reconstruction.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Bin Luo, Yu Luo, Lin He, Yangyang Cao, Qingsong Jiang
Summary: This study investigated the influence of residual periodontal ligament on the dentin regeneration potential of dental pulp stem cells (DPSCs) in the jaw. Results showed that the presence of residual periodontal ligament promoted the regeneration of dentin-like tissue and increased the expression of dentin-specific proteins. RNA-seq and bioinformatic analysis revealed potential key factors and signaling pathways involved in the regeneration process.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell & Tissue Engineering
Fariba Mohebichamkhorami, Roya Fattahi, Zahra Niknam, Morteza Aliashrafi, Sahar Khakpour Naeimi, Samira Gilanchi, Hakimeh Zali
Summary: Periodontal ligament stem cells (PDLSCs) have great potential for neural differentiation, capable of differentiating into various neural-like cells without the need for cell division. They can be induced towards neural lineage using a combination of nutritional factors and have significant implications for neural tissue repair when coupled with biomaterials. PDLSCs can be a valuable target for research and treatment of neurological disorders, such as Alzheimer's disease, multiple sclerosis, and cerebral ischemia. They also show beneficial effects on retinal ganglion cell regeneration and photoreceptor survival, and can be used for peripheral nerve repair through the expression of neural growth factors and differentiation into Schwann cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Poranee Banyatworakul, Thanaphum Osathanon, Sujin Chumprasert, Prasit Pavasant, Nopadon Pirarat
Summary: The study showed that PRF derived from Thai buffaloes was more beneficial for the proliferation of canine periodontal ligament cells (cPDLs) compared to PRF derived from Murrah buffaloes, and also promoted cell migration and spreading. Additionally, PRF from Thai buffaloes enhanced mineral deposition in an osteogenic induction medium.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Ilaria Roato, Beatrice Masante, Giovanni Putame, Diana Massai, Federico Mussano
Summary: This review provides an overview of recent advancements in periodontal tissue engineering, focusing on the use of PDLSCs and 3D scaffolds. The findings demonstrate the potential of these methods for innovative therapies in the future.
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
