Article
Cardiac & Cardiovascular Systems
Shiyun Wang, Zixuan Deng, Hong Zhang, Rong Zhang, Dandan Yan, Xiaojiao Zheng, Weiping Jia, Cheng Hu
Summary: Hp genotype affects the association between DDAH 1 rs233109 and diabetic macroangiopathy in Chinese patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, Research & Experimental
Yichen Zhao, Xiaoye Ma, Yuchen Zhou, Junchao Xie, Xueyuan Liu, Yanxin Zhao
Summary: Dimethylarginine dimethylamino hydrolase-1 (DDAH-1) plays a protective role in ischemic stroke by regulating ADMA levels and preventing tight junction protein degradation, thus protecting the blood-brain barrier. Supplementation of L-arginine helps restore DDAH-1 function.
LABORATORY INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Elisangela C. P. Lopes, Layde R. Paim, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Eduarda O. Z. Minin, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Licio A. Velloso, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: This study evaluated the relationship between circulating miRNAs and left ventricular hypertrophy (LVH) in hypertensive patients. The results showed that miR-145-5p, miR-451, and let7c were independently associated with LVH and left ventricular mass index. These miRNAs were also found to regulate genes and pathways related to cardiac remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Su-Hai Fei, Zhen-Feng Liu, Hai-Ning Xie, Jia-Ni Tong, Zheng-Mei Fang, Yan Chen, Ying-Shui Yao
Summary: In this study, miRNA's diagnostic value for hypertension with left ventricular hypertrophy was evaluated through meta-analysis. The results showed that miRNA has high sensitivity and specificity in this diagnosis, making it a better biological marker.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang
Summary: This study identified blood biomarkers for hypertensive left ventricular hypertrophy (LVH) using bioinformatics tools and experimental verification. LAPTM5 was found to be a potential diagnostic marker for LVH in patients with hypertension (HT).
Article
Cardiac & Cardiovascular Systems
Thu-Thao Le, Vanessa Lim, Rositaa Ibrahim, Muh-Tyng Teo, Jennifer Bryant, Briana Ang, Boyang Su, Tar-Choon Aw, Chi-Hang Lee, Jeroen Bax, Stuart Cook, Calvin W. L. Chin
Summary: The newly derived remodelling index (RI) provides prognostic value in risk stratification of hypertensive left ventricular hypertrophy (LVH), with patients with low RI showing a significantly higher risk of adverse events compared to those with normal RI. Concentric and eccentric LVH are associated with similar adverse prognosis, indicating the potential clinical implications of the RI in predicting cardiovascular events in hypertensive patients with LVH.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Flavio D'Ascenzi, Caterina Fiorentini, Francesca Anselmi, Sergio Mondillo
Summary: Athletes' hearts undergo remodeling due to exercise, but this can sometimes be mistaken for pathological hypertrophy seen in cardiac disorders like hypertension. Differentiating between athlete's heart and hypertensive heart disease can be challenging due to similar changes in left ventricular mass and wall thickness caused by training.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ping Guan, Jun Gu, Zhi-ping Song, Chang-qian Wang, Wei Hu, Jun-feng Zhang
Summary: This study found that a quarter of patients with hypertensive left ventricular hypertrophy and HFpEF progress to systolic dysfunction during a 5-year follow-up, with poor clinical outcomes. Beta-blocker therapy may play a protective role in preserving LVEF, and the transition of LV geometry is uncommon.
Article
Medicine, General & Internal
Anett Apitz, Thenral Socrates, Thilo Burkard, Michael Mayr, Annina S. Vischer
Summary: The study aimed to investigate the prevalence of left ventricular hypertrophy (LVH) in patients with arterial hypertension (AHT) and describe patients with severe LVH. The results showed that over half of the AHT patients (52.5%) had abnormal left ventricular geometry, and 7.3% had severe LVH. Patients with severe LVH were more likely to be male, older, have uncontrolled blood pressure (especially during sleep), receive multiple antihypertensive treatments, and have comorbidities compared to those with normal left ventricular geometry.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ahmed Mohamed Youssef, Hesham Abdallah Elghoneimy, Maged Wasfy Helmy, Ahmed Mokhtar Abdelazeem, Noha Mahmoud El-Khodary
Summary: The study demonstrated that compared to bisoprolol, amlodipine resulted in significantly greater reductions in LVMI and ADMA levels in hypertensive patients on HD, supporting the re-evaluation of amlodipine as a potential first-line antihypertensive treatment in this population.
Review
Peripheral Vascular Disease
R. Nadarajah, P. A. Patel, M. H. Tayebjee
Summary: Left ventricular hypertrophy secondary to systemic hypertension may increase the risk of ventricular arrhythmias, but its link to sustained arrhythmias and sudden cardiac death is unclear, possibly due to confounding factors like co-existing asymptomatic coronary artery disease.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Review
Biochemistry & Molecular Biology
Ljuba Bacharova, Marta Kollarova, Branislav Bezak, Allan Bohm
Summary: Left ventricular hypertrophy (LVH) refers to the complex rebuilding of the left ventricle, which can lead to heart failure and life-threatening ventricular arrhythmias. Imaging methods such as echocardiography and cardiac magnetic resonance can diagnose the increase in left ventricle size, while other methods can evaluate the functional status and underlying processes of LVH. Molecular and genetic biomarkers offer insights and potential for targeted therapy. This review summarizes the main biomarkers used in LVH evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Milan Vecsey-Nagy, Balint Szilveszter, Marton Kolossvary, Melinda Boussoussou, Borbala Vattay, Xenia Gonda, Zoltan Rihmer, Bela Merkely, Pal Maurovich-Horvat, Janos Nemcsik
Summary: This study aimed to assess the association between affective temperaments and left ventricular hypertrophy (LVH) in chronic hypertensive patients. The study found that cyclothymic affective temperament scores and elevated BMI significantly increased the odds of LVH in patients.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Psychiatry
Milan Vecsey-Nagy, Balint Szilveszter, Marton Kolossvary, Melinda Boussoussou, Borbala Vattay, Xenia Gonda, Zoltan Rihmer, Bela Merkely, Pal Maurovich-Horvat, Janos Nemcsik
Summary: This study aimed to assess the association between affective temperaments and left ventricular hypertrophy (LVH) in chronic hypertensive patients. The results showed that elevated BMI and cyclothymic affective temperament scores significantly increased the odds of LVH. Assessing affective temperaments may help identify chronic hypertensive patients at higher risk for LVH.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hayati Eren, Muhammed Bahadir Omar, Ulker Kaya, Lutfi Ocal, Mehmet Inanir, Asli Gozek Ocal, Omer Genc, Selin Genc, Ahmet Guner, Mucahit Yetim
Summary: The study found that in hypertensive patients with LVH, EAT thickness and MA prevalence were significantly higher than in other groups, and EAT thickness and left ventricular mass index were determined as independent predictors for MA development in hypertensive patients with LVH.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)