Article
Pharmacology & Pharmacy
Hak-Il Lee, Won-Kyu Rhim, Eun-Young Kang, Bogyu Choi, Jun-Hyeok Kim, Dong-Keun Han
Summary: The study proposed a multilayer-coated balloon catheter to enhance drug transfer efficiency, effectively load drugs, and reduce drug loss during treatment. Experimental results show that this method can be effectively applied to coronary intervention.
Article
Cardiac & Cardiovascular Systems
Daniele Giacoppo, Hector A. Alvarez-Covarrubias, Tobias Koch, Salvatore Cassese, Erion Xhepa, Thorsten Kessler, Jens Wiebe, Michael Joner, Willibald Hochholzer, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner
Summary: This study aims to compare the interventional strategies for the treatment of drug-eluting stent (DES) in-stent restenosis (ISR). The comparative efficacy and safety of plain balloon (PB), paclitaxel-coated balloon (PCB), and paclitaxel-eluting stent (PES) for percutaneous coronary intervention (PCI) of DES-ISR were evaluated for a 10-year follow-up. The results showed no significant difference among the treatments in clinical follow-up and primary endpoints, but PES and PCB were significantly superior to PB in target lesion revascularization.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Hongfei Xi, Jiasi Liu, Tao Xu, Zhe Li, Xuanting Mou, Yu Jin, Shudong Xia
Summary: This study analyzed the risk factors for in-stent restenosis (ISR) after the first implantation of drug-eluting stents (DES) in patients with coronary heart disease (CHD) and developed a nomogram model to predict the risk of ISR. The study identified hypertension, HbA1c, mean stent diameter, total stent length, thyroxine, and fibrinogen as important predictors for ISR. The nomogram prediction model can effectively identify high-risk individuals and provide practical decision-making information for follow-up interventions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Mangesh Sane, Vikas Dighe, Rucha Patil, Puthusserickal A. Hassan, Santosh Gawali, Vandana Patravale
Summary: Localized drug delivery with sustained elution characteristics from nanocarrier coated stents is a viable therapeutic approach to address concerns related to coronary stent therapy. A Sirolimus and Bivalirudin releasing nanoparticles (NPs) coated stent was fabricated for concurrent mitigation of vascular restenosis and acute stent thrombosis, showing superior anti-proliferative activity and higher cellular uptake in human coronary artery smooth muscle cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Clinical Neurology
Jiang-Hua Si, Ning Ma, Feng Gao, Da-Peng Mo, Gang Luo, Zhong-Rong Miao
Summary: This study compared the effectiveness of drug-eluting stents (DES) and bare metal stents (BMS) in the treatment of symptomatic intracranial and vertebral artery stenosis. The results showed that the use of DES resulted in a lower risk of in-stent restenosis (ISR) compared to BMS, with similar rates of successful stent implantation and adverse events. These findings support the use of DES for patients with symptomatic intracranial and vertebral artery stenosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Takahiro Jimba, Masayasu Ikutomi, Atsuko Tsukamoto, Masashiro Matsushita, Masao Yamasaki
Summary: This study investigated the impact of hinge motion on stent edge-related restenosis (SER) in the right coronary artery (RCA) after implantation of current-generation drug-eluting stents (DES). The results indicated that hinge angle and residual plaque burden were independent predictors of SER, with a synergistic effect observed when excessive hinge motion and residual plaque burden coexisted. These findings suggest that mechanical stress at stent edges and its interaction with residual plaque may contribute to SER progression.
CIRCULATION JOURNAL
(2021)
Article
Medicine, General & Internal
Minsu Kim, Albert Youngwoo Jang, Joonpyo Lee, Jeongduk Seo, Yong Hoon Shin, Pyung Chun Oh, Soon Yong Suh, Kyounghoon Lee, Woong Chol Kang, Seung-Hwan Han
Summary: This study compared the clinical outcomes of drug-eluting balloon (DEB) angioplasty and drug-eluting stent (DES) implantation in DES in-stent restenosis (ISR) lesions. The results showed that there was no significant difference in target lesion revascularization between the DEB and DES groups during the 7-year follow-up period. However, the DEB group had better safety outcomes, with lower rates of myocardial infarction and target lesion thrombosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Matej Strycek, Lukas Jaworski, Rostislav Polasek, Pavol Tomasov
Summary: Coronary artery perforation is a rare but potentially fatal complication of percutaneous coronary intervention. We report a case of massive main vessel coronary perforation in a patient with acute ST segment elevation myocardial infarction, which was successfully treated with a second drug-eluting stent. This unusual therapeutic approach was used to maintain blood flow to the large side branch.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Surgery
Shigeo Ichihashi, Mitsuyoshi Takahara, Terutoshi Yamaoka, Masayuki Hara, Taira Kobayashi, Hiroaki Tamai, Satoru Nagatomi, Kimihiro Igari, Masayuki Endo, Hidetoshi Uchiyama, Francesco Bolstad, Shinichi Iwakoshi, Naoki Fujimura, Takao Ohki, Kimihiko Kichikawa
Summary: This study compared the clinical data between VIABAHN stent grafts and Eluvia drug eluting stents in femoropopliteal arterial lesions. The results showed that Eluvia DES had a higher primary patency rate, freedom from target lesion revascularization, and freedom from acute limb ischaemia accompanying loss of patency, compared to VIABAHN stent grafts, especially in lesions <= 15 cm.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Gennaro Giustino, Antonio Colombo, Anton Camaj, Keisuke Yasumura, Roxana Mehran, Gregg W. Stone, Annapoorna Kini, Samin K. Sharma
Summary: Drug-eluting stent technologies have greatly improved the effectiveness and safety of percutaneous coronary interventions. However, in-stent restenosis (ISR) remains a significant public health concern. This paper comprehensively reviews the incidence, mechanisms, and imaging characteristics of ISR, and proposes a contemporary treatment algorithm.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Wansong Hu, Jun Jiang
Summary: This article describes the relationship between in-stent restenosis (ISR) and hypersensitivity reactions in patients with coronary heart disease (CHD) after percutaneous transluminal coronary intervention (PCI). With the emergence of drug-eluting stents (DES), the efficacy and prognosis of CHD patients have greatly improved, but the components of DESs can still induce hypersensitivity reactions and lead to long-term adverse cardiovascular events.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ioanna Samara, Christos S. Katsouras, Arsen Semertzioglou, Athanassios Vratimos, Amalia I. Moula, Constantinos A. Dimitriou, Michail Theofanis, Triantafyllia Papadimitropoulou, Vasileios Bouratzis, Georgia Karanasiou, Dimitrios Fotiadis, Lampros K. Michalis, Anargyros N. Moulas
Summary: This study evaluated the safety and efficacy of innovative retinoic acid (RA) eluting stents with bioabsorbable polymer. The results showed that RA eluting stents did not lead to thrombus formation and had an acceptable level of stenosis after 4 weeks of implantation. The dose of RA and type of polymer may play a role in the biocompatibility of the stents.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Ae-Young Her, Eun-Seok Shin, Sunwon Kim, Bitna Kim, Tae-Hyun Kim, Chang-Bae Sohn, Byung Joo Choi, Yongwhi Park, Jung Rae Cho, Young-Hoon Jeong
Summary: This study investigated the clinical impact of drug-coated balloon (DCB) treatment in patients with diabetes mellitus (DM) and multivessel coronary artery disease (CAD), and found that DCB treatment reduced the risk of major adverse cardiovascular events (MACE) in patients with DM, but not in those without DM.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fatih Levent, Oktay Senoz, Sadik Volkan Emren, Zeynep Yapan Emren, Rahman Bilal Gediz
Summary: The severity of coronary artery tortuosity is associated with in-stent restenosis in patients with stable and unstable angina undergoing drug-eluting stent implantation for a severe single coronary artery, with higher tortuosity indices predicting a higher risk of restenosis.
Article
Cardiac & Cardiovascular Systems
Sebastian Kufner, Himanshu Rai, Jens Wiebe, Felix Altevogt, Stylianos Pyxaras, Michael Joner, Erion Xhepa, Salvatore Cassese, Roisin Colleran, Heribert Schunkert, Bernhard Zrenner, Adnan Kastrati, Robert A. Byrne
Summary: In patients with drug-eluting stent restenosis, angioplasty with a novel paclitaxel-coated balloon (PCB) with citrate-based excipient was non-inferior to PCB with iopromide excipient in terms of angiographic outcome.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
