期刊
MEDICAL CLINICS OF NORTH AMERICA
卷 97, 期 1, 页码 91-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2012.10.005
关键词
Type 2 diabetes; Diabetic nephropathy; Kidney disease; Genetic risk
资金
- National Institutes of Health [DK090125, DK58549, DK77532, DK53534]
In this review, the authors discuss the major approaches being used to identify diabetic nephropathy (DN) susceptibility genes in type 2 diabetes (12D) and highlight the salient findings from studies whereby these approaches have been implemented. The recent advent of next-generation sequencing technology is beginning to impact DN gene mapping strategies. As the field moves forward, family based approaches should greatly facilitate efforts to identify variants in genes that have a major effect on the risk of DN in T2D. To be successful, the ascertainment and comprehensive study of families with multiple affected members is critical.
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