Article
Biochemistry & Molecular Biology
Judit Symmank, Sophie Appel, Jana Asisa Bastian, Isabel Knaup, Jana Marciniak, Christoph-Ludwig Hennig, Annika Doding, Ulrike Schulze-Spate, Collin Jacobs, Michael Wolf
Summary: This study aimed to investigate the effects of hyperlipidemia and bacterial infection on cytokine expression and secretion in HPdLF cells. The results showed that hyperlipidemic conditions increased the susceptibility of HPdLF to inflammatory response to compressive forces, especially when cells were simultaneously exposed to bacterial components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yujun Jiang, Panpan Yang, Congshan Li, Yupu Lu, Yuying Kou, Hongrui Liu, Jie Guo, Minqi Li
Summary: This research investigated the role of periostin in periodontitis and its underlying mechanism. The results showed that decreased periostin expression was associated with periodontitis, and overexpression of periostin suppressed cell apoptosis and reversed the inhibitory effect of lipopolysaccharide on Nrf2 expression. This suggests that periostin could be a potential therapeutic target for periodontitis.
Article
Immunology
Katarzyna B. Lagosz-Cwik, Mariia Melnykova, Elwira Nieboga, Aureliusz Schuster, Agnieszka Bysiek, Slawomir Dudek, Weronika Lipska, Malgorzata Kantorowicz, Michal Tyrakowski, Dagmara Darczuk, Tomasz Kaczmarzyk, Marjolijn Gilijamse, Teun J. de Vries, Jan Potempa, Aleksander M. Grabiec
Summary: Interactions between gingival fibroblasts (GFs) and oral pathogens play a role in the development of chronic inflammation in periodontitis. Epigenetic changes in DNA methylation are associated with periodontitis, and DNMT inhibitors have been shown to protect against epithelial barrier disruption and bone resorption. However, the use of DNMT inhibitors may have detrimental effects on GFs, including reduced proliferation, increased inflammation, and enhanced bacterial adherence.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Wei He, Yu Fu, Song Yao, Lan Huang
Summary: The periodontal ligament consists of fibroblasts, cementoblasts, osteoblasts, osteoclasts, periodontal ligament stem cells (PDLSCs), and epithelial cell rests of Malassez. The regulation of programmed cell death is important for immune response but can also lead to the loss of periodontal supporting tissues and root resorption. These findings are relevant for understanding periodontitis and orthodontic root resorption. This comprehensive review focuses on recent studies on mechanisms of periodontal ligament cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Junhong Xiao, Xin Huang, Huiyi Wang, Yan Peng, Heyu Liu, Hantao Huang, Li Ma, Chuan Wang, Xiaoxuan Wang, Zhengguo Cao
Summary: In this study, the levels of CKIP-1 expression and autophagy were shown to increase in periodontal tissues. The knockout of CKIP-1 was found to activate autophagy, and activating autophagy was shown to reduce inflammation in periodontal tissues. These findings demonstrate the important role of CKIP-1 in regulating periodontal tissue inflammation.
Article
Biochemistry & Molecular Biology
Siqi Yao, Chenxi Jiang, Huihui Zhang, Xudong Gao, Yi Guo, Zhengguo Cao
Summary: The study demonstrated that visfatin is highly expressed in inflamed human gingiva and Pg LPS-treated periodontal cells, and partially regulates the expression of proinflammatory and prodegradative factors through the NF-kappa B pathway. This suggests that visfatin may play a critical role in the development of periodontitis and could be a promising therapeutic target.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Immunology
Shuangshuang Li, Huilin Xu, Yuanyuan Li, Ruijing Li
Summary: In this study, it was found that circular RNA_0138960 promotes dysfunction in LPS-induced periodontal ligament cells by targeting the miR-518a-5p/HDAC6 axis, providing new potential therapeutic targets for periodontitis.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kecong Zhou, Mengjun Sun, Yiru Xia, Yufeng Xie, Rong Shu
Summary: This study found that in the periodontal inflammatory state, the expression of PD-L1 in HGFs is significantly higher than in the periodontal healthy group, and may be influenced by the p38 pathway.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Chao-Yen Huang, Pei-Ling Hsieh, Min Yee Ng, Yi-Wen Liao, Cheng-Chia Yu, Taichen Lin
Summary: Periodontitis is a leading cause of tooth loss in adults, and periodontal ligament fibroblasts play a crucial role in maintaining and regenerating periodontal tissue. This study found that the forced expression of galectin-7 in these fibroblasts enhanced cell proliferation, migration, invasion, and wound healing capabilities. These findings suggest that increasing galectin-7 expression in the periodontium may promote tissue regeneration by recruiting more fibroblasts to the site of injury.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Immunology
Bing-Yan Wang, Aize Cao, Meng-Hsuan Ho, Derek Wilus, Sally Sheng, Hsiu-Wan Meng, Elissa Guerra, Jianming Hong, Hua Xie
Summary: The present study aimed to identify risk factors associated with periodontitis development and periodontal health disparities, focusing on differential oral microbiota. The prevalence of periodontitis is increasing among dentate adults in the US, posing challenges to oral and overall health. African Americans (AAs) and Hispanic Americans (HAs) have a higher risk of developing periodontitis compared to Caucasian Americans (CAs). The study analyzed the distribution of beneficial and pathogenic bacteria in the oral cavities of AA, CA, and HA participants. The results suggest that socioeconomic disadvantages, higher levels of Porphyromonas gingivalis, and specific types of P. gingivalis fimbriae, particularly type II FimA, contribute to the risks of periodontitis development and periodontal health disparities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bohan Yu, Jiahui Hu, Qin Li, Fang Wang
Summary: The study revealed the impact of circMAP3K11 on the function of hPDLSCs in periodontitis via regulating the miR-511-3p/TLR4 axis, providing a scientific basis for periodontal tissue regeneration therapy based on stem cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Qingsong Jiang, Yuxi Zhao, Yusen Shui, Xuedong Zhou, Lei Cheng, Biao Ren, Zhu Chen, Mingyun Li
Summary: Late-onset periodontitis is closely related to the interactions between neutrophils and periodontal pathogens, where the balance between neutrophils and the microbial community is crucial. Neutrophils clear pathogens mainly through phagocytosis and release mechanisms, while pathogens evade neutrophil-mediated killing through various strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Fan Gu, Hailin Wu, Zhuo Huang, Fei Wang, Ruihuan Yang, Zhuan Bian, Miao He
Summary: This study demonstrates that PDLFs and DPCs are more sensitive to cytoplasmic LPS-induced noncanonical pyroptosis and that DMF treatment can block cell death. This suggests that DMF might be a promising drug for the management of pulpitis and apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Review
Cell Biology
Koji Naruishi
Summary: Periodontal diseases, including periodontitis and gingival overgrowth, have different causes. Periodontitis is caused by bacterial infection, while gingival overgrowth is a side effect of specific drugs. Human gingival fibroblasts and human periodontal ligament fibroblasts play crucial roles in the remodeling and homeostasis of periodontal tissue.
Article
Oncology
Yaru Wei, Zhengjun Peng
Summary: The study revealed the crucial role of hsa_circ_0099630 in periodontitis, showing its ability to inhibit cell proliferation and osteogenic differentiation while inducing apoptosis.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)