Article
Plant Sciences
Chuang Xiao, Sha Cheng, Haochang Lin, Zhiying Weng, Peihua Peng, Deyou Zeng, Xiaohua Du, Xiujuan Zhang, Yaqing Yang, Yaping Liang, Rong Huang, Chen Chen, Lueli Wang, Hongxiang Wu, Runfeng Li, Xinhua Wang, Rongping Zhang, Zifeng Yang, Xian Li, Xue Cao, Weimin Yang
Summary: ISOF shows anti-COPD effects by improving lung function, anti-inflammation, and trachea relaxation, possibly through AC activation, mTOR signaling, and Th17/Treg balance.
Article
Immunology
Sung-Min Kim, Eun-Jung Park, Hae-Jeung Lee
Summary: Nuciferine extracted from lotus leaves shows anti-inflammatory effects by inhibiting the production of inflammatory mediators and targeting the NF-kappa B and p38 MAPK/ATF2 signaling pathways in LPS-induced macrophages.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Immunology
Angela Rico de Souza, Hussein Traboulsi, Xinyu Wang, Jorg H. Fritz, David H. Eidelman, Carolyn J. Baglole
Summary: Research suggests that inhibiting AhR will enhance cigarette smoke-induced pulmonary neutrophilia, but the mechanism of AhR's anti-inflammatory function remains unclear. Through the use of AhR antagonists and genetically modified mice, the study shows that features such as nuclear translocation and binding of response elements are not necessary for AhR to suppress pulmonary neutrophilia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pritam Saha, Sneha Durugkar, Siddhi Jain, P. A. Shantanu, Samir R. Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V. G. M. Naidu
Summary: The study found that PIP treatment can protect cells from CSE-induced lung epithelial cell death. PIP treatment can restore epithelial markers and reduce mesenchymal and inflammatory markers in both in vitro and in vivo models. PIP treatment can improve altered lung function in mice induced by CS exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wang
Summary: This study found that astaxanthin can attenuate DNA damage and apoptosis caused by cigarette smoke, and reduce the activation of Caspase-3. Astaxanthin can also decrease the production of intracellular reactive oxygen species by suppressing the expression of NOX4 and DUOX1.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wenyao Su, Qiying Nong, Jie Wu, Ruihong Fan, Yuanting Liang, Anyi Hu, Zhongxiang Gao, Weihui Liang, Qifei Deng, Hailan Wang, Lihua Xia, Yongshun Huang, Yiru Qin, Na Zhao
Summary: This study found that bone marrow mesenchymal stem cells (BMSCs) attenuate silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome pathways in lung macrophages. Additionally, the study identified tumor necrosis factor-stimulated gene 6 (TSG-6) as a key paracrine secretion factor released from BMSCs, which exerts a protective effect by regulating the activation of inflammasome in macrophages. Treatment with exogenous recombinant mouse TSG-6 also showed similar effects in attenuating silica-induced inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Junfa Yang, Lei Xu, Meifei Wu, Hui Fang, Yuchen Lu, Congjian Shi, Yang Wang, Shaowei Jiang, Qiang Ma, Zeng Li, Lingling Zhang, Lei Zhang
Summary: DPF-6, a derivative of paeonol, exerts anti-inflammatory effects by upregulating the expression of ZEB2 and inhibiting the secretion of inflammation cytokines. This compound may be utilized as a potential therapeutic agent for acute liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lijuan Gao, Ni Zeng, Zhicheng Yuan, Tao Wang, Lei Chen, Deqing Yang, Dan Xu, Chun Wan, Fuqiang Wen, Yongchun Shen
Summary: This study investigated the role of FPR-1 in CS-induced airway inflammation using KO technology and transcriptional study, revealing that KO of FPR-1 significantly ameliorates inflammation through immune-chemotaxis responses and inhibition of NF-kappa B activation in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjing Liu, Zhonggui Gong, Kanglei Zhang, Wenxuan Dong, Hui Zou, Ruilong Song, Jianchun Bian, Jiaqiao Zhu, Gang Liu, Zongping Liu
Summary: This study found that Paeonol can alleviate Cd-induced renal cytotoxicity by alleviating oxidative stress, inhibiting inflammatory responses, and restoring autophagy, potentially serving as a new candidate drug to treat Cd-induced nephrotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Immunology
Lin Zhang, Lukun Yang, Xiaowei Xie, Hongyue Zheng, Hangsheng Zheng, Lizong Zhang, Cuizhe Liu, Ji-Gang Piao, Fanzhu Li
Summary: Baicalin magnesium salt (BA-Mg), extracted from the traditional Chinese medicine Scutellaria baicalensis Georgi, is a water-soluble ingredient that can effectively alleviate inflammatory response and oxidative stress induced by lipopolysaccharide (LPS), potentially through inhibiting the activation of the TLR4/NF-kappa B signaling pathway.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Xin Zhang, Suliang Guo, Xiaoxi Huang, Biyun Li, Huaping Dai, Chen Wang
Summary: The study found that F528 can reduce cigarette smoke-induced inflammation and emphysema by inhibiting the activation of NF-kappa B, thereby protecting lung function, reducing the production of inflammatory cells and cytokines.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sang Min Lee, Kyung-No Son, Dhara Shah, Marwan Ali, Arun Balasubramaniam, Deepak Shukla, Vinay Kumar Aakalu
Summary: This study investigated the effects of histatin-1 (Hst1) on LPS-induced inflammatory responses and the underlying molecular mechanisms in RAW264.7 (RAW) macrophages. The results demonstrated that Hst1 can inhibit LPS-induced inflammatory mediator production and MAPK signaling pathways in macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Faezeh Niazi Shahraki, Saeideh Momtaz, Maryam Baeeri, Danial Khayatan, Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Ali Reza Abdollahi, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This study evaluated the anti-inflammatory effects of Licofelone in a rat model of acetic acid-induced colitis. The results showed that Licofelone attenuated colitis, increased superoxide dismutase activity, and significantly reduced colonic levels of inflammatory factors. Additionally, the concurrent use of nitric oxide synthase inhibitors with Licofelone reversed the observed positive effects, demonstrating the role of nitric oxide in the pathogenesis of inflammatory bowel disease and the mechanism of action of Licofelone in colitis healing.
Article
Neurosciences
Hsueh-Te Lee, Kuan-I Lee, Hui-Ching Lin, Tzong-Shyuan Lee
MOLECULAR NEUROBIOLOGY
(2019)
Article
Physiology
Jin-Feng Zhao, Hsiang-Ying Chen, Jeng Wei, Shr-Jeng Jim Leu, Tzong-Shyuan Lee
Article
Physiology
An-Hsuan Lin, Meng-Han Liu, Hsin-Kuo Ko, Diahn-Warng Perng, Tzong-Shyuan Lee, Yu Ru Kou
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Cell Biology
Chih-Chan Lien, Chia-Hui Chen, Yeng-Ming Lee, Bei-Chia Guo, Li-Ching Cheng, Ching-Chien Pan, Song-Kun Shyue, Tzong-Shyuan Lee
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Chia-Hui Chen, Jin-Feng Zhao, Chiao-Po Hsu, Yu Ru Kou, Tse-Min Lu, Tzong-Shyuan Lee
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Medicine, General & Internal
Chung-Kuan Wu, Chia-Lin Wu, Tzu-Cheng Su, Yu Ru Kou, Chew-Teng Kor, Tzong-Shyuan Lee, Der-Cherng Tarng
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Nutrition & Dietetics
Po-An Hu, Chia-Hui Chen, Bei-Chia Guo, Yu Ru Kou, Tzong-Shyuan Lee
Article
Biochemistry & Molecular Biology
Chung-Kuan Wu, Chia-Lin Wu, Tzong-Shyuan Lee, Yu Ru Kou, Der-Cherng Tarng
Summary: The study found that TRPA1 plays a role in AKI by sensing oxidative stress and regulating inflammation in renal tubular cells. TRPA1 expression increased in patients with AKI and in a mouse model of IR-induced injury, highlighting its importance in kidney injury. In vitro experiments showed that TRPA1 activation by ROS under hypoxia-reoxygenation injury conditions led to increased intracellular Ca2+ level and activation of inflammatory signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chung-Kuan Wu, Ji-Fan Lin, Tzong-Shyuan Lee, Yu Ru Kou, Der-Cherng Tarng
Summary: TRPA1 plays dual roles in sensory neurons and non-neuronal cells, promoting tissue repair, clearing harmful stimuli, and inducing protective responses, while also potentially contributing to disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Man-Chen Hsu, Wei-Jia Luo, Bei-Chia Guo, Chia-Hui Chen, Po-An Hu, Yi-Hsuan Tsai, Kang-Yi Su, Tzong-Shyuan Lee
Summary: In this study, the role of HLJ1 in blood coagulation was investigated using wild-type mice and HLJ1-null mice. The results suggest that although HLJ1 is present in megakaryocytes and platelets, it may not play a role in blood coagulation under normal physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Po-An Hu, Sz-Han Wang, Chia-Hui Chen, Bei-Chia Guo, Jenq-Wen Huang, Tzong-Shyuan Lee
Summary: Bromelain has anticoagulant effects on non-alcoholic fatty liver disease-induced blood coagulation deregulation by inhibiting the activation of the coagulation cascade, decreasing the stability of clots, and promoting fibrinolytic activity. The findings suggest the potential therapeutic value of bromelain for thrombosis-related diseases.
Article
Biochemistry & Molecular Biology
Chia-Hui Chen, Chien-Chung Hsia, Po-An Hu, Chung-Hsin Yeh, Chun-Tang Chen, Cheng-Liang Peng, Chih-Hsien Wang, Tzong-Shyuan Lee
Summary: Bromelain, a cysteine protease found in pineapple, has been found to have beneficial effects in the treatment of inflammatory diseases. In this study, the effects of bromelain on hyperlipidemia and atherosclerosis in mice were investigated. It was found that daily administration of bromelain improved hyperlipidemia, reduced aortic inflammation, and slowed down the progression of atherosclerosis. The mechanisms underlying these effects involve the promotion of cholesteryl ester hydrolysis, autophagy, and antioxidant capacity through the AMPK/TFEB signaling pathway.
Article
Biochemistry & Molecular Biology
Ko-Lin Kuo, Chin-Wei Chiang, Yi-Ming Arthur Chen, Chih-Chin Yu, Tzong-Shyuan Lee
Summary: Folic acid has anti-inflammatory and antifibrotic effects. The major folic acid-binding protein in the liver, GNMT, regulates cellular methylation and may be a therapeutic target in treating renal fibrosis. Increased expression of GNMT was observed in humans with obstructive nephropathy and in mice with unilateral ureteral obstruction. Folic acid treatment alleviated renal injury in wild-type mice, but not in GNMT knockout mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Transplantation
Ko-Lin Kuo, Der-Cherng Tarng, Tzong-Shyuan Lee
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Article
Cell Biology
Chia-Hui Chen, Song-Kun Shyue, Chiao-Po Hsu, Tzong-Shyuan Lee
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)