Review
Medicine, Research & Experimental
Roberta Mastrantonio, Hua You, Luca Tamagnone
Summary: Semaphorins play a crucial role in cancer by controlling various biological processes, especially in cell-cell communication, migration, metastasis, and immune responses. Research suggests that Semaphorins could serve as important biomarkers for predicting patient survival and treatment response in cancer. Targeting Semaphorin signaling has shown potential in interfering with tumor growth and metastasis, making it a promising avenue for novel therapeutic strategies in cancer treatment.
Article
Medical Laboratory Technology
Mina Yekani, Mohammad Yousef Memar
Summary: Meningitis is a severe inflammation of the meninges, caused by bacteria or viruses, with high mortality rates. Immunologic biomarkers, such as cytokines and acute phase proteins, have been identified as significant indicators for diagnosing bacterial meningitis. However, the sensitivity and specificity of these biomarkers are influenced by various factors. This study provides an overview of different immunologic biomarkers and their efficiency in diagnosing bacterial meningitis and differentiating it from viral meningitis.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Criselda Jean G. Cruz, Chao-Chun Yang
Summary: Psoriasis is a chronic, multisystemic inflammatory disease that affects millions of people globally, characterized by erythematous, thick, scaly plaques on the skin. Clinical evaluation remains the gold standard for diagnosis and monitoring, but molecular detection methods, such as enzyme-linked immunosorbent assay (ELISA), can help guide clinical decisions and therapeutic strategies by quantifying circulating biomarkers that reflect the underlying pathogenic events.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Oncology
Jessica Vieira de Assis, Lucelia Antunes Coutinho, Ifeoluwa Temitayo Oyeyemi, Oyetunde Timothy Oyeyemi, Rafaella Fortini e Queiroz Grenfell
Summary: This review provides an overview of recent advances in the search for colorectal cancer biomarkers through genomics and proteomics, with emphasis on their clinical applications for diagnosis and prognosis of the disease.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Kurpet, Grazyna Chwatko
Summary: Psoriasis is a common inflammatory skin disease characterized by excessive production of antimicrobial peptides and proteins. These molecules have potential as diagnostic biomarkers and therapeutic targets for inflammatory diseases.
Article
Immunology
Piero Ruscitti, Maria Esposito, Ilenia Di Cola, Cristina Pellegrini, Andrea De Berardinis, Mirco Mastrangelo, Camilla Gianneramo, Antonio Barile, Maria Concetta Fargnoli, Paola Cipriani
Summary: This study aimed to evaluate biomolecules in naive patients with psoriasis (PSO), psoriatic arthritis (PSA) with PSO, and PSA sine PSO. The results showed that these patients have a similar cytokine profile, suggesting the concept of a psoriatic disease continuum. However, differences were also found, indicating possible pathogenic differences and contributing to the clinical heterogeneity of these patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Valeria Conti, Graziamaria Corbi, Francesco Sabbatino, Domenico De Pascale, Carmine Sellitto, Berenice Stefanelli, Nicola Bertini, Matteo De Simone, Luigi Liguori, Ilenia Di Paola, Maddalena De Bernardo, Angela Tesse, Nicola Rosa, Pasquale Pagliano, Amelia Filippelli
Summary: Long COVID or post-COVID-19 syndrome (PCS) refers to the development of persistent symptoms and/or complications in patients diagnosed with COVID-19. The pathogenesis and course of this syndrome are influenced by factors such as age, sex/gender, and pre-existing conditions. The lack of precise diagnostic and prognostic biomarkers complicates the clinical management of patients. This review aims to summarize recent evidence on the factors influencing PCS, possible biomarkers, and therapeutic approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Allergy
Grace C. Lee, Marcos I. Restrepo, Nathan Harper, Muthu Saravanan Manoharan, Alisha M. Smith, Justin A. Meunier, Sandra Sanchez-Reilly, Aamir Ehsan, Anne P. Branum, Caitlyn Winter, Lauryn Winter, Fabio Jimenez, Lavanya Pandranki, Andrew Carrillo, Graciela L. Perez, Antonio Anzueto, Hanh Trinh, Monica Lee, Joan M. Hecht, Celida Martinez-Vargas, Raj T. Sehgal, Jose Cadena, Elizabeth A. Walter, Kimberly Oakman, Raymond Benavides, Jacqueline A. Pugh, Scott Letendre, Maristella Steri, Valeria Orru, Edoardo Fiorillo, Francesco Cucca, Alvaro G. Moreira, Nu Zhang, Elizabeth Leadbetter, Brian K. Agan, Douglas D. Richman, Weijing He, Robert A. Clark, Jason F. Okulicz, Sunil K. Ahuja
Summary: The study found that differences in levels of immunologic resilience may lead to variations in mortality rates among COVID-19 patients. Females typically have higher immunologic resilience, while males are more susceptible to severe COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Artur T. L. Queiroz, Mariana Araujo-Pereira, Beatriz Barreto-Duarte, Adriano Gomes-Silva, Allyson G. Costa, Alice M. S. Andrade, Joao Pedro Miguez-Pinto, Renata Spener-Gomes, Alexandra B. Souza, Aline Benjamin, Flavia Sant'Anna, Marina C. Figueiredo, Vidya Mave, Padmini Salgame, Jerrold J. Ellner, Timothy R. Sterling, Marcelo Cordeiro-dos-Santos, Bruno B. Andrade, Valeria C. Rolla
Summary: This study assessed soluble factors to identify biomarkers associated with TB among persons with advanced HIV. The results showed that plasma concentrations of IL-15 and IL-10 can be used in combination to identify TB disease regardless of time on anti-TB treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Mayssa Hachem, Mirja Kaizer Ahmmed, Houda Nacir-Delord
Summary: Phospholipidomics is a specialized branch of lipidomics that provides valuable insights into the metabolism and activities of phospholipids in brain disorders. By identifying specific phospholipid biomarkers, it has the potential to enhance diagnosis and treatment options for neurological diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Inna S. Afonina, Elien Van Nuffel, Rudi Beyaert
Summary: Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation and aberrant differentiation of keratinocytes, leading to skin redness. The pathogenesis of psoriasis is still not completely understood, but genetic predisposition plays a significant role in its development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Doodipala Samba Reddy, Hasara Nethma Abeygunaratne
Summary: This article discusses the importance of biomarkers in diagnosing brain diseases and monitoring therapeutic interventions. It explains that biomarkers can be measured objectively and used as indicators for pathological processes or response to treatments. Different types of biomarkers, including blood-based, immunohistochemical-based, neuroimaging-based, and electrophysiological biomarkers, are used to study and monitor acute and chronic brain conditions. The article highlights the significance of biomarkers in identifying specific molecules, cells, tissues, or proteins that change throughout the progression of brain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Stephen R. Pennington, Oliver FitzGerald
Summary: Although having skin/nail psoriasis is an important risk factor for developing psoriatic arthritis (PsA), it alone is not sufficient to identify which patients with psoriasis will develop PsA. Further molecular assessment of psoriasis patients may help refine the profile of those at risk of developing PsA, leading to the design of disease prevention studies and new treatment approaches.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Kelly Butler, A. Rouf Banday
Summary: APOBECs are cytosine deaminases involved in immunity, but some members can cause oncogenic mutations. This review summarizes the evidence of APOBEC3 as major mutators and explores the triggers of APOBEC3 expression and mutational activity. It also discusses how APOBEC3-mediated mutagenesis affects tumor evolution and the potential therapeutic applications.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Sabine Seeler, Liviu-Ionut Moldovan, Trine Bertelsen, Henrik Hager, Lars Iversen, Claus Johansen, Jorgen Kjems, Lasse Sommer Kristensen
Summary: Psoriasis is a common chronic inflammatory skin disease. The dynamics of non-coding RNA expression during treatment can provide insights into the disease mechanism and treatment effectiveness.
Letter
Dermatology
M. C. Fargnoli, M. Esposito, S. Ferrucci, G. Girolomoni, A. Offidani, A. Patrizi, K. Peris, A. Costanzo, G. Malara, G. Pellacani, M. Romanelli, P. Amerio, A. Cristaudo, M. L. Flori, A. Motolese, P. Betto, C. Patruno, P. Pigatto, C. Peccianti, G. Stinco, I. Zalaudek, L. Bianchi, V. Boccaletti, S. P. Cannavo, F. Cusano, S. Lembo, R. Mozzillo, R. Gallo, C. Potenza, F. Rongioletti, R. Tiberio, T. Grieco, G. Micali, S. Persechino, M. Pettinato, S. Pucci, L. Stingeni, C. Caruso, G. Argenziano
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Caterina Lanna, Claudia Galluzzi, Arianna Zangrilli, Mauro Bavetta, Luca Bianchi, Elena Campione
Summary: This study evaluated the impact of psoriasis on different body sites on the quality of life of patients and observed changes in quality of life during treatment. The results showed that itching acts as a mediator between the extension of psoriasis and its impact on quality of life, and nail psoriasis plays a predominant role in affecting the quality of life of patients.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Laura Diluvio, Chiara Pensa, Arianna Piccolo, Caterina Lanna, Luca Bianchi, Elena Campione
Summary: The number of individuals suffering from autoimmune conditions is increasing in Western countries, and they are often prone to developing a second autoimmune disorder. This case report demonstrates the successful treatment of a patient with psoriasis vulgaris and chronic spontaneous urticaria using a combination of two different antibodies. The study suggests that the two therapies may act synergistically to achieve a favorable outcome.
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Cosimo Di Raimondo, Ludovico Rao, Flavia Lozzi, Paolo Lombardo, Dionisio Silvaggio, Laura Vellucci, Lorenzo Tofani, Elena Campione, Luca Bianchi
DERMATOLOGIC THERAPY
(2022)
Review
Pharmacology & Pharmacy
Caterina Lanna, Sara Lambiase, Ruslana Gaeta Shumak, Cristiana Borselli, Terenzio Cosio, Annunziata Dattola, Luca Bianchi, Elena Campione
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Dermatology
Enzo Berardesca, Adriana Bonfigli, Claudia Cartigliani, Delphine Kerob, Jerry Tan
Summary: This study assessed the effectiveness of M89PF in patients with rosacea, erythema, and sensitive skin using protective face masks during the Covid-19 pandemic. The results showed that M89PF significantly improved erythema, skin tightness, dryness, TEWL, and skin hydration, while reducing skin sensitivity.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Terenzio Cosio, Filadelfo Coniglione, Valeria Flaminio, Roberta Gaziano, Deborah Coletta, Rosalba Petruccelli, Emi Dika, Luca Bianchi, Elena Campione
Summary: Immunotherapy in oncology is replacing traditional therapies due to its specific action and limited side effects. However, bacterial infections can still occur as side effects. This case report highlights the importance of considering lifestyle and cutaneous background before starting immunotherapy for cancer treatment, with a focus on pharmacogenomics and the possibility of modified skin microbiota predisposing to cutaneous infections in patients treated with PD-1 inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Cosimo Di Raimondo, Paolo Lombardo, Cristiano Tesei, Fabiana Esposito, Federico Meconi, Roberto Secchi, Flavia Lozzi, Alessandro Monopoli, Maria Grazia Narducci, Enrico Scala, Cecilia Angeloni, Alberto De Stefano, Siavash Rahimi, Luca Bianchi, Maria Cantonetti
Summary: The neutrophil/lymphocyte ratio (NLR) is found to be associated with the severity and prognosis of various cancers, but its role in mycosis fungoides (MF) is unclear. This study aimed to assess the association of NLR with different stages of MF and determine if higher values are related to a more aggressive MF. The retrospective analysis of 302 MF patients found that higher NLR values were significantly associated with advanced stages of MF, suggesting that NLR can serve as a marker for advanced MF, guiding physicians in patient management.
Article
Chemistry, Medicinal
Elena Campione, Sara Lambiase, Ruslana Gaeta Shumak, Marco Galluzzo, Caterina Lanna, Gaetana Costanza, Cristiana Borselli, Fabio Artosi, Terenzio Cosio, Lorenzo Tofani, Annunziata Dattola, Francesca Di Daniele, Luca Bianchi
Summary: Tildrakizumab is an approved treatment for moderate-to-severe plaque-type psoriasis, targeting the p19 subunit of interleukin IL-23. A study was conducted on 53 psoriatic patients who received Tildrakizumab every 12 weeks for 52 weeks, showing significant improvement in Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), Nail Psoriasis Severity Index (NAPSI), and Palmoplantar Psoriasis Physician Global Assessment (PPPGA). Disease remission was achieved from week 16 and maintained until week 52.
Review
Biochemistry & Molecular Biology
Cosimo Di Raimondo, Flavia Lozzi, Pier Paolo Di Domenico, Elena Campione, Luca Bianchi
Summary: Melanoma, the deadliest form of skin cancer, accounts for almost 90% of skin cancer mortality. Despite advances in immune and targeted therapies, many patients still experience disease progression. Skin metastases, a common occurrence in melanoma, can be treated through various methods including surgery, injections, and systemic therapies. Further research is needed to understand the underlying mechanisms and differences in behavior and prognosis among melanoma patients with skin metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Cristina Rapanotti, Elisa Cugini, Elena Campione, Cosimo Di Raimondo, Gaetana Costanza, Piero Rossi, Amedeo Ferlosio, Sergio Bernardini, Augusto Orlandi, Anastasia De Luca, Luca Bianchi
Summary: The most promising method for monitoring patients with minimal morbidity is the detection of circulating melanoma cells (CMCs). We have shown that CD45(-)CD146(+)ABCB5(+) CMCs are a rare primitive stem/mesenchymal CMCs population associated with disease progression. Investigating the gene expression of isolated CMCs' epithelial-to-mesenchymal transition (EMT) gene signature can provide potential clinical value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tatiana Koudriavtseva, Svetlana Lorenzano, Maria Cellerino, Mauro Truglio, Marco Fiorelli, Caterina Lapucci, Giovanna D'Agosto, Laura Conti, Annunziata Stefanile, Silvana Zannino, Maria Maddalena Filippi, Antonio Cortese, Carlo Piantadosi, Marta Maschio, Andrea Maialetti, Edvina Galie, Marco Salvetti, Matilde Inglese
Summary: The objective of this observational study was to identify the most specific pro-coagulative/vascular factors for multiple sclerosis pathogenesis and to correlate them with brain hemodynamic abnormalities. The results showed that tissue-factor was one of the key variables in differentiating multiple sclerosis from controls and relapse from remission.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Cristina Morelli, Vincenzo Formica, Paolo Bossi, Michela Rofei, Simona Guerriero, Silvia Riondino, Renato Argiro, Noemi Pucci, Tonia Cenci, Luca Savino, Carla G. Rinaldi, Francesco Garaci, Augusto Orlandi, Rolando M. D'Angelillo, Hendrik-Tobias Arkenau, Mario Roselli, Nathan A. Berger
Summary: The study found that personalized SMI assessment based on gender and BMI is important for predicting survival in HNSCC patients, which can improve the clinical management of muscle wasting. The translation into Simplified Chinese suggests that the personalized SMI evaluation is of great significance for the management of HNSCC patients, especially the use of gender-based SMI cutoff values for prognosis.
Article
Dermatology
Elena Campione, Monia Di Prete, Gaetana Costanza, Andrea Saggini, Sara Agostinelli, Alessandro Terrinoni, Federica Centofanti, Maria Cristina Rapanotti, Luca Bianchi, Amedeo Ferlosio, Maria Giovanna Scioli, Augusto Orlandi
Summary: Research found that non-mutated patients with uterine leiomyomas have a higher occurrence of skin tumors, specifically cutaneous leiomyomas (CLs) and dermatofibromas (DFs), which may be linked to vitamin D deficiency.
