Article
Multidisciplinary Sciences
April S. Caravaca, Alessandro L. Gallina, Laura Tarnawski, Vladimir S. Shavva, Romain A. Colas, Jesmond Dalli, Stephen G. Malin, Henrik Hult, Hildur Arnardottir, Peder S. Olofsson
Summary: Stimulating the vagus nerve accelerates the resolution of inflammation in mice by increasing levels of SPM and shifting the balance between proinflammatory and proresolving lipid mediators. This process requires the enzyme Alox15 and the alpha 7nAChR receptor component of the inflammatory reflex.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Allergy
Ankit Srivastava, Longlong Luo, Warangkana Lohcharoenkal, Florian Meisgen, Lorenzo Pasquali, Andor Pivarcsi, Eniko Sonkoly
Summary: IFN-γ suppresses miR-149 to prime keratinocytes for inflammatory responses, leading to skin inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Magnavacca, Stefano Piazza, Anna Cammisa, Marco Fumagalli, Giulia Martinelli, Flavio Giavarini, Enrico Sangiovanni, Mario Dell'Agli
Summary: The study found that blackcurrant leaf extract has a better effect on interfering with IFN-gamma signaling compared to TNF-alpha or IL-4. This suggests that RNLE may have an anti-allergic effect in keratinocytes through mechanisms beyond histamine involvement.
Article
Immunology
Susana Lopez-Lopez, Maria Jose Romero de Avila, Natalia Carolina Hernandez de Leon, Francisco Ruiz-Marcos, Victoriano Baladron, Maria Luisa Nueda, Jorge Laborda, Jose Javier Garcia-Ramirez, Eva M. Monsalve, Maria Jose M. Diaz-Guerra
Summary: NOTCH4 acts as a negative regulator in macrophage activation by interfering with proinflammatory cytokine expression and signaling pathways such as IFN-gamma and STAT1. It also modulates the balance between STAT1 and STAT3 activation, impacting the transcriptional activity of macrophages. Moreover, NOTCH4 affects NF-kappa B and TLR signaling pathways, revealing new insights into the regulation of macrophage-specific effector functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jennifer Mecklenburg, Andi Wangzhou, Anahit H. Hovhannisyan, Priscilla Barba-Escobedo, Sergey A. Shein, Yi Zou, Korri Weldon, Zhao Lai, Vincent Goffin, Gregory Dussor, Alexei Tumanov, Theodore J. Price, Armen N. Akopian
Summary: This study developed pain models with sex-dependent resolution trajectories and identified factors associated with the resolution of pain in males and females. The results showed that different treatment protocols with prolactin (PRL) can lead to distinct pain development and resolution patterns, with acute PRL-evoked pain fully resolved within one day and prolonged high dose PRL treatment causing mechanical hypersensitivity that resolves within 5-7 days. Furthermore, pro-inflammatory responses in the hindpaws, particularly with macrophages/monocytes, were observed during pain resolution in both sexes.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, Research & Experimental
Ankur Das, Olivia Chowdhury, Payal Gupta, Nirmal Das, Ankan Mitra, Sourav Ghosh, Sayan Ghosh, Swaimanti Sarkar, Debasish Bandyopadhyay, Sreya Chattopadhyay
Summary: The aim of this study is to understand how exposure to different concentrations of arsenic affects the immune system and how arsenic-induced inflammation impacts T-regulatory cell bias, with a focus on the role of autophagy. The findings show that arsenic-induced oxidative stress activates NF-κB, which provokes pro-inflammatory responses and immune-suppressive activity depending on the dose of arsenic. Arsenic alters the interaction between NF-κBp65 and pSTAT-3, leading to the suppression of the IL-6/STAT-3/IL-17A feedback loop and activation of immune-suppression through NF-κB-driven Treg cell differentiation and autophagy.
Article
Immunology
Nadeem Akhter, Shihab Kochumon, Amal Hasan, Ajit Wilson, Rasheeba Nizam, Ashraf Al Madhoun, Fatema Al-Rashed, Hossein Arefanian, Fawaz Alzaid, Sardar Sindhu, Fahd Al-Mulla, Rasheed Ahmad
Summary: The co-stimulation of IFN-gamma and LPS can enhance the expression of CCL2 through the acetylation of H3K27, leading to augmented inflammation in obesity. These findings contribute to a better understanding of the regulatory mechanisms of CCL2 in the pathogenesis of obesity.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jee Hoon Lee, Ji-hye Han, Joo Hong Woo, Ilo Jou
Summary: The study found that oxysterols, specifically 25-hydroxycholesterol (25-HC), effectively suppresses neuroinflammation in microglia by disrupting membrane lipid rafts and caveolae-mediated endosomal IFN-gamma signaling. This suggests a potential new therapeutic target for inflammatory neurodegenerative diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Yanpeng Li, Haodong Cui, Shipeng Li, Xingyan Li, Hongtao Guo, Kutty Selva Nandakumar, Zhilei Li
Summary: Research has shown that Kaempferol can improve psoriasis and alleviate its skin lesions. It exerts its therapeutic effects by modulating the IFN-gamma-induced JAK-STAT signaling pathway and reducing the number of inflammatory cells. These findings provide a basis for clinical application.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Huanhuan Wang, Lingzhu Xie, Xuhong Song, Jing Wang, Xinyan Li, Zhike Lin, Ting Su, Bin Liang, Dongyang Huang
Summary: This study found that exogenous purines, through the action of interferon-gamma (IFN-gamma), increase XOR expression, leading to uric acid production. Clinical data showed a positive correlation between serum IFN-gamma concentrations and both purine and uric acid levels, as well as an increased risk of hyperuricemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
John M. Fenimore, Danielle A. Springer, Maria E. Romero, Elijah F. Edmondson, Dan W. McVicar, Sudhirkumar Yanpallewar, Michael Sanford, Thea Spindel, Elizabeth Engle, Thomas J. Meyer, Julio C. Valencia, Howard A. Young
Summary: The effect of cytokines on non-traditional immunological targets under conditions of chronic inflammation is explored. Fatigue is associated with autoimmune diseases, and immune dysfunction-driven changes in myocyte mitochondria are hypothesized to play a critical role in fatigue-related pathogenesis. The study shows that persistent low-level expression of IFN-gamma results in mitochondrial and metabolic deficiencies in myocytes, particularly affecting heart function under stress. These findings highlight the actions of IFN-gamma in fatigue, energy metabolism, and autoimmunity.
JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Yi-wen Lv, Yang Du, Sheng-suo Ma, Yu-cong Shi, Hua-chong Xu, Li Deng, Xiao-yin Chen
Summary: This study aimed to evaluate the protective effects of Proanthocyanidins (PAs) against Influenza A virus (IAV)-induced acute lung injury (ALI) and its potential mechanisms. The results demonstrated that PAs attenuated ALI induced by IAV through the TGF-beta 1/Smad2/3 signaling pathway and significantly reduced inflammation and ferroptosis. Therefore, PAs may be a promising therapeutic candidate for ALI.
Article
Cell Biology
Taylor Schmit, Kai Guo, Jitendra Kumar Tripathi, Zhihan Wang, Brett McGregor, Mitch Klomp, Ganesh Ambigapathy, Ramkumar Mathur, Junguk Hur, Michael Pichichero, Jay Kolls, M. Nadeem Khan
Summary: This study identifies IFN-gamma-regulated CCR2(+) monocytes as the main driver of lung damage during IAV infection. IFN-gamma regulates the recruitment and inflammatory phenotype of CCR2(+) monocytes. CD8+ T cells are the main source of IFN-gamma in the infected lungs.
Article
Biochemistry & Molecular Biology
Sergei Butenko, Nofar Ben Jashar, Tsofiya Sheffer, Edmond Sabo, Sagie Schif-Zuck, Amiram Ariel
Summary: The atypical chemokine receptor ACKR2 plays a crucial role in limiting inflammatory skin fibrosis by promoting IFN-beta production to resolve inflammation and minimize tissue scarring.
Article
Immunology
Amro M. Soliman, Taekwan Yoon, Jiahui Wang, James L. Stafford, Daniel R. Barreda
Summary: The study investigates the kinetics of leukocyte recruitment in fish skin infections, demonstrating early upregulation of inflammatory cytokines and migration of neutrophils to the injury site. Resolution of inflammation is marked by reduction in reactive oxygen species and pro-inflammatory cytokines expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lijing Zhang, Yingqiu Qi, Huan Min, Chen Ni, Fei Wang, Bin Wang, Hao Qin, Yinlong Zhang, Guangna Liu, Yue Qin, Xixi Duan, Feng Li, Xuexiang Han, Ning Tao, Lirong Zhang, Zhihai Qin, Ying Zhao, Guangjun Nie
Article
Cell Biology
Mingming Wang, Wanpeng Yu, Jun Gao, Wenqiang Ma, Macro Frentsch, Andreas Thiel, Mei Liu, Nafis Rahman, Zhihai Qin, Xiangdong Li
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Food Science & Technology
Jing Ma, Jie Mei, Jia Lu, Yuanyuan Wang, Minghua Hu, Fangli Ma, Hanan Long, Zhihai Qin, Ning Tao
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Guo-Jun Zhang, Ran Dong, Li-Na Lan, Shu-Fen Li, Wu-Jun Gao, Hong-Xing Niu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Yanan Li, Jun Wang, Kun Song, Shuangqing Liu, Huilei Zhang, Fei Wang, Chen Ni, Wenlong Zhai, Jialu Liang, Zhihai Qin, Jinhua Zhang
Review
Cell Biology
Zhenzhen Li, Yanan Li, Shuangqing Liu, Zhihai Qin
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Cancan Du, Xixi Duan, Xiaohan Yao, Jiajia Wan, Yanru Cheng, Yuan Wang, Yan Yan, Lijing Zhang, Linyu Zhu, Chen Ni, Ming Wang, Zhihai Qin
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Medicine, Research & Experimental
Pan Ma, Yue Qin, Hong Cao, Ulrike Erben, Chen Ni, Zhihai Qin
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Medicine, Research & Experimental
Yuan Wang, Haiyang Liu, Yangyang Bian, Junfeng An, Xixi Duan, Jiajia Wan, Xiaohan Yao, Cancan Du, Chen Ni, Linyu Zhu, Ningjing Lei, Fei Wang, Lijing Zhang, Ming Wang, Zhihai Qin
Article
Chemistry, Medicinal
Jie Mei, Jing Ma, Yuwei Xu, Yuanyuan Wang, Minghua Hu, Fangli Ma, Zhihai Qin, Rui Xue, Ning Tao
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)
Article
Oncology
Ming Wang, Zhongyu Qin, Jiajia Wan, Yan Yan, Xixi Duan, Xiaohan Yao, Ziming Jiang, Wenqing Li, Zhihai Qin
Summary: This study found that tumor-derived exosomes can induce the formation of pre-metastatic niche in the lung by promoting the differentiation of regulatory T cells. This is achieved through the activation of the specific receptor CCR8 by secreted CCL1, resulting in the establishment of an immunologically tolerant microenvironment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Hong Cao, Chen Ni, Le Han, Ruoqi Wang, Rosel Blasig, Reiner Haseloff, Yue Qin, Jie Lan, Xiaohan Lou, Pan Ma, Xiaohan Yao, Linlin Wang, Fei Wang, Linyu Zhu, Ningjing Lei, Ingolf E. Blasig, Zhihai Qin
Summary: This study found that the absence of tight junction protein Claudin-12 (Cldn12) inhibited the growth of transplanted tumors and reduced the accumulation of myeloid-derived suppressor cells (MDSCs) within tumors, resulting in increased anti-tumor immune responses. The study also revealed that expression of Cldn12 on the cell surface of both MDSCs and endothelial cells (EC) is necessary for MDSCs to cross tumor vascular ECs. Therefore, Cldn12 shows promise as a target for restoring anti-tumor response by interfering with MDSCs transendothelial migration.
Article
Chemistry, Multidisciplinary
Yongjuan Li, Ningjing Lei, Xiaohan Yao, Yu Zhang, Ya Dong, Jinmeng Yi, Xinyan Li, Wenjing Deng, Guangjun Nie, Zhihai Qin
Summary: A polyvalent ferroptosis agonist, hPPAA18C6, is developed to stimulate ferroptosis by releasing endogenous iron and depleting glutathione in hypoxia. In addition, hPPAA18C6 acts as an immune adjuvant, facilitating dendritic cells maturation and CD8(+) T-cell activation. The combination of hPPAA18C6 and Ce6 leads to combined therapeutic outcomes in primary, distant, and metastatic tumors.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Wenqing Li, Zihao Wang, Ziming Jiang, Yan Yan, Xiaohan Yao, Zhenzhen Pan, Lin Chen, Fei Wang, Ming Wang, Zhihai Qin
Summary: The study found that miR-3960 levels in bladder cancer tissue were positively correlated with patient survival time. miR-3960 inhibited bladder cancer growth and promoted drug-induced apoptosis by suppressing DEXI expression. These findings suggest that miR-3960 could be a potential therapeutic strategy against bladder cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Jing Ma, Xu Chen, Rui Xue, Fei Wang, Jun Dong, Ning Tao, Zhihai Qin
Summary: This study screened several natural compounds for their inhibitory effects on cytokine storms and found that cinnamaldehyde can effectively inhibit the production of cytokine storms and restore the number of T cells.
PHYTOTHERAPY RESEARCH
(2023)