Article
Biochemistry & Molecular Biology
Parveen Kumar, Vivek Verma, Dheeraj Mohania, Surbhi Gupta, Avneet K. Babbar, Bhawna Rathi, Rakesh S. Dhanda, Manisha Yadav
Summary: The study revealed that RUNX1T1 is mutated in different cancers and associated with poor overall survival in glioma patients, possibly affecting glioma growth and development through HIF1α regulation. Experimental results showed that downregulation of RUNX1T1 may lead to degradation of HIF1α, reducing proliferation and invasiveness of glioblastoma cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Clinical Neurology
Lauren Dzikowski, Reza Mirzaei, Susobhan Sarkar, Mehul Kumar, Pinaki Bose, Anita Bellail, Chunhai Hao, V. Wee Yong
Summary: The study investigated the expression of ECM molecules in GBM patients, the effects of different ECM molecules on BTICs in culture, and the association between ECM molecules and MMP-2 and -9 in resected GBM specimens.
Article
Cell Biology
Yin-Hung Chu, Wen-Chieh Liao, Ying-Jui Ho, Chih-Hsien Huang, To-Jung Tseng, Chiung-Hui Liu
Summary: This study explores the role of chondroitin sulfate (CS) in glioma progression, focusing on the effects of the major CS synthase CHSY1 and the interaction with CD44 and integrin beta 1. It suggests a potential regulatory loop between CS, CD44, and integrin beta 1 in glioma cells, highlighting the importance of CS in CD44 stability. Targeting CS with specific binding peptides shows promise as a novel therapeutic strategy for glioma.
Article
Oncology
Jiaoyun Lv, Suhua Chen, Xin Chen, Jiawei Xie, Ziyi He, Tianrui Fan, Kaiming Ma, Kayisaier Abudurousuli, Jun Yang, Xiaoyan Qiu, Hui Dai
Summary: In glioma, high levels of IgG transcription are associated with poor prognosis, and glioma-derived IgG promotes cell proliferation and migration through the HGF/SF-Met or FAK/Src pathway.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Neurosciences
Yuan Wang, Di Zhao, HaiBo Wang, ShuWei Wang, HaoLiang Zhang, Huan Liu, KaiJie Wang
Summary: Glioma is a prevalent malignancy in the brain, and lncRNA-LINC00941 has been found to be highly expressed in all subtypes of glioma. Over-expression of lncRNA-LINC00941 promotes cellular proliferation and invasiveness, and inhibits apoptosis in U87 cells. Targeting lncRNA-LINC00941 could be a potential strategy for glioma management.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Xuguang Lin, Kenichi Watanabe, Masahiro Kuragano, Kiyotaka Tokuraku
Summary: The study found that AEFs extracted and purified from different animal species (camel, cat, cattle, goat, and mouse) could promote mouse SAA protein aggregation in vitro, with mouse and cat AEFs showing higher mSAA aggregation-promoting activity than camel, cattle, and goat AEFs. This suggests that AA amyloidosis exhibits higher transmission activity among animals carrying genetically homologous SAA gene, providing a new understanding of the pathogenesis of amyloidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rodney H. Falk, Mia Haddad, Crystal R. Walker, Sharmila Dorbala, Sarah A. M. Cuddy
Summary: The study showed that tafamidis therapy significantly increases serum TTR levels in patients with ATTR cardiomyopathy, indicating a stabilizing effect. Changes in TTR levels post-therapy may serve as a surrogate marker for stabilization and a more accurate measure of drug efficacy compared to in vitro tests.
JACC: CARDIOONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masafumi Tanaka, Toru Takarada, Satomi Nadanaka, Risa Kojima, Kimiko Hosoi, Yuki Machiba, Hiroshi Kitagawa, Toshiyuki Yamada
Summary: In this study, the effects of N-terminal modifications on amyloid fibril formation were investigated using a peptide corresponding to the N-terminal region of the SAA molecule. It was found that carbamoylation of the N-terminal amino group delayed the formation of amyloid fibrils, while acetylation or truncation of the N-terminal amino acids diminished the amyloidogenic properties. Cell toxicity assays showed that SAA peptides reduced cell reductive activity, but did not cause release of LDH. N-terminal truncation had no effect on cell activity or LDH release. These findings suggest that N-terminal modifications of SAA molecules can regulate susceptibility to AA amyloidosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Su-Chun How, Ta-Hsien Lin, Chun-Chao Chang, Steven S-S Wang
Summary: In this study, beta-lactoglobulin (β-LG) combined with bovine serum albumin (BSA) was utilized to prepare amyloid-based hydrogels for riboflavin delivery. The presence of BSA enhanced β-LG fibril formation but also interfered with the entanglement of fibril chains, affecting the mechanical properties of the hydrogels. The number of amyloid fibrils was found to positively correlate with the mechanical properties of the hydrogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biotechnology & Applied Microbiology
Junjie Wang, Zeyu Li, Fenfen Yin, Rui Zhang, Ying Zhang, Zhengxin Wang, Xiumei Sheng
Summary: GLIPR1 plays a dual role in cancer, acting as an oncoprotein in some types such as gliomas and breast cancers, while functioning as a tumor suppressor in others like prostate cancers and lung cancers. The mechanisms of GLIPR1 in different tumors remain unclear, but it shows potential in cancer treatment through gene therapy and protein therapy.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Nhan Hau Tran, Vyacheslav Ryzhov, Andrey Volnitskiy, Dmitry Amerkanov, Fedor Pack, Aleksander M. Golubev, Alexandr Arutyunyan, Anastasiia Spitsyna, Vladimir Burdakov, Dmitry Lebedev, Andrey L. Konevega, Tatiana Shtam, Yaroslav Marchenko
Summary: In this study, the potential of iron oxide nanoparticles as radiosensitizers in glioblastoma cells was evaluated. The results showed that the nanoparticles can significantly enhance the effect of X-ray irradiation, while having a weaker or no effect on gamma and proton irradiation. The findings suggest that the nanoparticles may enhance radiation therapy by generating secondary electrons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yang Cai, Ming Wang, Yan Cui, Zhigang Tan, Yugang Jiang
Summary: The study explored the differential expression of lncRNAs in glioma and identified lncRNA NKX3-1 as a key player in cancer promotion through the Fem1b/SPDEF pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Clara Quijano-Rubio, Manuela Silginer, Michael Weller
Summary: This study found that canonical CD95L may not be expressed in human glioma-initiating cells (GIC) but there exists a CD95L-independent CD95 signaling pathway that maintains malignant traits of the cells. The findings highlight the complexity and challenges associated with targeting CD95 for therapeutic purposes.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Multidisciplinary
Dongmiao Qin, Shuo Meng, Yusheng Wu, Guichun Mo, Xiaohua Jiang, Biyang Deng
Summary: In this study, a dual-wavelength ratiometric electrochemiluminescence sensor was developed for sensitive detection of Aβ(42), showing satisfactory stability, high sensitivity, good reproducibility, and excellent specificity.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Benita Wiatrak, Paulina Jawien, Agnieszka Matuszewska, Adam Szelag, Adriana Kubis-Kubiak
Summary: This study aimed to investigate the impact of amyloid fragments on oxidative stress and found that amyloid fragments have antioxidant properties, protecting neurons from neuroinflammation-induced damage. Among the tested fragments, the 1-40 fragment showed a stronger antioxidant effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Carlos Poblete Jara, Beatriz de Andrade Berti, Natalia Ferreira Mendes, Daiane Fatima Engel, Ariane Maria Zanesco, Gabriela Freitas Pereira de Souza, Renan de Medeiros Bezerra, Julia de Toledo Bagatin, Silvya Stuchi Maria-Engler, Joseane Morari, William H. Velander, Licio A. Velloso, Eliana Pereira Araujo
Summary: The study demonstrates that exogenous glutamic acid can promote hair growth and keratinocyte proliferation, while reducing apoptosis-related gene expression and increasing cell viability and proliferation. These findings suggest a potential novel skin signalling pathway mediated by neurotransmitters in controlling skin cell growth, offering new possibilities for using glutamic acid in the treatment of skin diseases.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Karin J. P. Rocha-Brito, Stefano Piatto Clerici, Helon Guimaraes Cordeiro, Amanda Petrina Scota Ferreira, Emanuella Maria Barreto Fonseca, Paola R. Goncalves, Julia Laura F. Abrantes, Renato Milani, Renato Ramos Massaro, Silvya Stuchi Maria-Engler, Carmen Ferreira-Halder
Summary: The study showed that the efficacy of quercetin in killing melanoma cells depends on its ability to inhibit tyrosine kinase and upregulate mitochondrial proteins. Quercetin was found to reduce cell viability in SKMEL-103 but not in SKMEL-28 cells, suggesting different responses in these melanoma cell lines.
BIOLOGICAL CHEMISTRY
(2022)
Article
Dermatology
Maryana Stephany Ferreira Branquinho, Maysa Braga Barros Silva, Gabriela Ansanelo Castilho, Jacqueline Cavalcante, Silvia Berlanga de Moraes Barros, Renan Orsati Clara, Silvya Stuchi Maria-Engler, Ana Campa
Summary: Kynurenine has been found to inhibit melanin production and may play a role in the process of melanogenesis. While there were no significant changes in tryptophan metabolism, the high consumption of kynurenic acid may be associated with this process.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Adamo Davi Diogenes Siena, Isabela Ichihara de Barros, Camila Baldin Storti, Carlos Alberto Oliveira de Biagi Junior, Larissa Anastacio da Costa Carvalho, Silvya Stuchi Maria-Engler, Josane de Freitas Sousa, Wilson Araujo Silva Jr
Summary: This study investigates the role of lncRNA U73166 in melanoma progression and resistance to vemurafenib. Experimental results show that lncRNA U73166 is associated with migration and invasion in melanoma cells, and its expression is higher in vemurafenib-resistant samples. These findings suggest that lncRNA U73166 could be a potential biomarker or target for overcoming clinical vemurafenib resistance.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Larissa A. C. Carvalho, Rodrigo G. Queijo, Alexandre L. B. Baccaro, Adamo D. D. Siena, Wilson A. Silva Jr, Tiago Rodrigues, Silvya Stuchi Maria-Engler
Summary: Melanoma, the most aggressive type of skin cancer, is influenced by redox imbalance and redox proteins may serve as biomarkers and potential targets. Understanding genetic alterations and protein expression in melanoma patients can provide clues for new therapies.
Article
Oncology
Sofia Birkealv, Mark Harland, Larissa Satiko Alcantara Sekimoto Matsuyama, Mamun Rashid, Ishan Mehta, Jonathan P. Laye, Kerstin Haase, Tracey Mell, Vivek Iyer, Carla Daniela Robles-Espinoza, Ultan McDermott, Peter van Loo, Marieke L. Kuijjer, Patricia A. Possik, Silvya Stuchi Maria Engler, D. Timothy Bishop, Julia Newton-Bishop, David J. Adams
Summary: This study conducted sequence profiling of 524 American Joint Committee on Cancer Stage I-III primary tumors, revealing recurrent driver mutations, mutually exclusive genetic interactions, and an absence of co-occurring genetic events. By intersecting copy number calls with CRISPR screening data, the transcription factor IRF4 was identified as a melanoma-associated dependency.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Clara N. Brathwaite, Thuany Alencar-Silva, Larissa A. C. Carvalho, Maryana S. F. Branquinho, Ricardo Ferreira-Nunes, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Silvya S. Maria-Engler, Juliana Lott Carvalho, Joyce K. R. Silva, Tais Gratieri
Summary: In this study, the depigmenting action of Pouteria macrophylla fruit extract was verified, and a safe topical microemulsion was developed. The microemulsion showed a more pronounced depigmenting effect compared to a commercial formulation, and it was non-irritating to the skin.
Article
Biochemistry & Molecular Biology
Liliana Ivet Sous Naasani, Jessica Goncalves Azevedo, Jean Sevigny, Tiago Franco de Oliveira, Silvya Stuchi Maria-Engler, Marcia Rosangela Wink
Summary: This study analyzed the expression of ectonucleotidases in hEM cells derived from discarded foreskin. The results showed that NTPDase1 and ecto-5-nucleotidase had higher expressions. After cell injury, the released ATP by hEM was hydrolyzed by NTPDase1, impacting the levels of nucleotides in the skin micro-environment.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patrik da Silva Vital, Murilo Bonatelli, Marina Pereira Dias, Larissa Vedovato Vilela de Salis, Mariana Tomazini Pinto, Fatima Baltazar, Silvya Stuchi Maria-Engler, Celine Pinheiro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jeniffer Farias Dos Santos, Bruna Leticia Freitas-Marchi, Gustavo Roncoli Reigado, Silvia Romano de Assis, Silvya Stuchi Maria Engler, Felipe Santiago Chambergo Alcalde, Viviane Abreu Nunes
Summary: In skin traumas, tissue engineering using mesenchymal stem cells (MSC) from the umbilical cord shows promise for skin regeneration. MSCs can differentiate into keratinocytes and express important epidermal markers, indicating their potential use in producing skin substitutes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Andressa Cristina Antunes Santos, Denisse Esther Mallaupoma Camarena, Gustavo Roncoli Reigado, Felipe S. Chambergo, Viviane Abreu Nunes, Marco Antonio Trindade, Silvya Stuchi Maria-Engler
Summary: Cultivated meat (CM) technology is an alternative solution to the environmental, health and ethical issues associated with meat production. This review provides an overview of CM production, including the cultivation process, cell sources, medium requirements, and technological aspects of 3D models. The article also discusses the main obstacles to CM production and provides an outlook on the global CM market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ylana Adami Franco, Manoel Oliveira de Moraes Jr, Larissa A. C. Carvalho, Wolfgang Dohle, Renaira Oliveira da Silva, Isabella Harumi Yonehara Noma, Keli Lima, Barry V. L. Potter, Joao A. Machado-Neto, Silvya Stuchi Maria-Engler
Summary: The sulfamoylated derivative of endogenous estradiol, STX140, shows superior potential as a therapeutic agent for melanoma treatment. It inhibits cell proliferation, induces cell cycle arrest and apoptosis, reduces migration and clonogenic potential, and inhibits invasion in melanoma cells. Furthermore, STX140 induces senescence features and activates the senescence machinery in melanoma cells. These findings suggest that STX140 may be a promising candidate for melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Liliana Ivet Sous Naasani, Jessica Gonsalves Azevedoa, Jean Sevigny, Tiago Franco de Oliveira, Silvya Stuchi Maria-Engler, Marcia Rosangela Wink
Summary: This study reveals the expression and function of ectonucleotidases in human epidermal melanocytes, suggesting their involvement in regulating nucleotide levels in the skin microenvironment.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Priscilla Tobias Ribeiro, Tatiana do Nascimento Pedrosa, Francisco Celio Maia Chaves, Lucindo Jose Quintans-Junior, Adriano Antunes de Souza Araujo, Marne Carvalho de Vasconcellos, Silvya Stuchi Maria-Engler, Claudia Candida Silva, Felipe Moura Araujo da Silva, Hector Henrique Ferreira Koolen, Emerson Silva Lima, Adley Antonini Neves de Lima
Summary: This study investigated the pharmacognostic characteristics, extract production, antioxidant potential evaluation, and application in cosmetic products of a Passiflora species, Passiflora nitida Kunth, which is little studied. The results showed that the extract of P. nitida exhibited promising antioxidant and antimelanogenic effects, indicating its potential for the development of cosmetic formulations.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Meeting Abstract
Cell & Tissue Engineering
Luiz Henrique Catalani, Denisse Esther Mallaupoma Camarena, Larissa Sekimoto, Silvya Stuchi Maria-Engler
TISSUE ENGINEERING PART A
(2022)