Review
Immunology
Anna Torun, Anna Hupalowska, Piotr Trzonkowski, Jaroslaw Kierkus, Beata Pyrzynska
Summary: The incidence and prevalence of chronic inflammatory disorders are increasing in the pediatric population, with recent research highlighting the importance of interactions between altered intestinal microbiome and the immune system in disease pathogenesis. Therapies for these disorders mainly focus on symptom management, with sustained improvement being difficult to achieve due to challenges like changing physiology and susceptibility to adverse medication effects in children. New therapeutic approaches targeting the gut microbiota and immune system hold promise for inducing long-lasting remission and improving the quality of life for pediatric patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Luis A. Constantino-Jonapa, Yoshua Espinoza-Palacios, Alma R. Escalona-Montano, Paulina Hernandez-Ruiz, Luis M. Amezcua-Guerra, Amedeo Amedei, Maria M. Aguirre-Garcia
Summary: Trimethylamine N-oxide (TMAO) is associated with increased incidence of cardiovascular diseases and is affected by factors such as diet, drugs, age, and hormones. Recent studies have shown that gut dysbiosis is a new approach for understanding various inflammatory diseases. Diabetic and obese patients have increased levels of TMAO, which is directly correlated with cardiovascular diseases.
Article
Gastroenterology & Hepatology
Badar Hasan, Yunjoo Yim, Mamoon Ur Rashid, Rumman A. Khalid, Deepika Sarvepalli, Daniel Castaneda, Asad Ur Rahman, Nicole Palekar, Roger Charles, Fernando J. Castro, Bo Shen
Summary: The study demonstrates that hyperbaric oxygen therapy is effective and safe for chronic antibiotic-refractory pouchitis and other inflammatory conditions of the pouch. It significantly improves symptoms and endoscopic parameters in patients, despite minor adverse events.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Jungyoon Ohn, Mingyu Jang, Bo Mi Kang, Huisuk Yang, Jin Tae Hong, Kyu Han Kim, Ohsang Kwon, Hyungil Jung
Summary: The newly designed candle flame-shaped TA-loaded dissolving microneedles can effectively treat chronic inflammatory skin diseases, reduce patient pain, and are favored by dermatologists.
Review
Biochemistry & Molecular Biology
Santina Venuto, Anna Rita Daniela Coda, Ruperto Gonzalez-Perez, Onofrio Laselva, Doron Tolomeo, Clelia Tiziana Storlazzi, Arcangelo Liso, Massimo Conese
Summary: The lung is an important organ for gas exchange and immune response. The insulin-like growth factor (IGF) system and its binding proteins (IGFBPs) play a role in the development of the lung as well as the pathogenesis of respiratory diseases and lung tumors. Among the IGFBPs, IGFBP-6 has emerged as a mediator of airway inflammation and tumor suppression in lung tumors. This review focuses on the multiple roles of IGFBP-6 in respiratory diseases, including its function in inflammation, fibrosis, and different types of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jerko Stambuk, Frano Vuckovic, Sinisa Habazin, Maja Hanic, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel, Gordan Lauc, Konrad Aden, Marija Pezer
Summary: Immunosuppressants and biologicals impact the glycosylation of serum immunoglobulin G (IgG) in patients with chronic inflammatory diseases (CID). The study reveals a decrease in IgG glycosylation in CID patients, while an increase in glycosylation is observed in patients undergoing therapy and in remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Analytical
Isidro Badillo-Ramirez, Yojana J. P. Carreon, Claudia Rodriguez-Almazan, Claudia M. Medina-Duran, Selene R. Islas, Jose M. Saniger
Summary: This article introduces the recent advances and potential of graphene derivative materials (GDMs) in developing biosensors. These materials have excellent properties and play an important role in the simple, accurate, and sensitive detection of biomarkers. Through electrochemical and optical sensing methods, these materials can be integrated into robust, wearable, remote, and smart biosensor devices for the detection of biomarkers for chronic inflammatory diseases.
Review
Geriatrics & Gerontology
Shun Liu, Weihua Nong, Lin Ji, Xiuhong Zhuge, Huimei Wei, Min Luo, Leguang Zhou, Shenghua Chen, Shun Zhang, Xiaocan Lei, Hua Huang
Summary: Inflammation and telomeres are involved in a feedback regulatory loop, where inflammation increases telomere attrition and telomere components participate in regulating the inflammatory response. The specific mechanism behind this feedback loop is not fully understood.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MPAK signaling pathway.
Review
Immunology
Bimei Song, Yue Zeng, Yanqing Cao, Jiamin Zhang, Chao Xu, Yaping Pan, Xida Zhao, Jingbo Liu
Summary: Despite improvements in medical therapies, inflammatory diseases still pose a significant threat to human health and cause a substantial financial burden. N6-methyladenosine (m6A) modification of RNA plays a crucial role in the pathogenesis of various diseases. This review focuses on the role of METTL3, the most discussed m6A methyltransferase, in inflammatory diseases, summarizing its expression changes, modified target genes, and pathogenesis in different disease categories. Additionally, therapeutic applications targeting METTL3 using natural plant drug components are discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yi Xing, Xun Sun, Yiming Dou, Min Wang, Yanmei Zhao, Qiang Yang, Yanhong Zhao
Summary: Extracellular vesicles (EVs) act as natural nanocarriers and intercellular messengers, playing a crucial role in cell communication, while macrophage-derived EVs may have significant implications in the development of chronic inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yilin Song, Qing You, Xiaoyuan Chen
Summary: Inflammatory disease refers to a class of diseases in which chronic inflammation is the major manifestation of pathogenesis. Traditional therapies based on anti-inflammatory and immunosuppressive drugs only provide short-term remission. The emergence of nanodrugs holds great potential for the treatment of inflammatory diseases by addressing potential causes and preventing recurrences. Transition metal-based smart nanosystems (TMSNs) possess unique electronic structures and therapeutic advantages, making them promising for the treatment of various inflammatory diseases.
ADVANCED MATERIALS
(2023)
Article
Clinical Neurology
Cheng Jiang, Han Yin, Anbang Liu, Quanjun Liu, Huan Ma, Qingshan Geng
Summary: The study examines the association between Dietary Inflammatory Index (DII) and depression in patients with chronic diseases and comorbidity. The findings suggest that a higher DII is associated with an increased risk of depression in participants with chronic diseases and comorbidity, especially among those less than 60 years and men.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Plant Sciences
Deng Ran, Wu Hong, Wang Yan, Wang Mengdie
Summary: Geniposide (GE) is a compound commonly found in medicinal plants, with strong therapeutic activity against chronic inflammatory diseases. Numerous in vivo and in vitro experiments have confirmed the therapeutic value of GE for various chronic inflammatory conditions, with mechanisms mainly involving anti-inflammatory, antioxidant, and neuroprotective properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Lillie M. Powell, Soo Jeon Choi, Breanna L. Haught, Ryan Demkowicz, P. Rocco LaSala, Slawomir Lukomski
Summary: This study in West Virginia found that the emm92 type of Group A Streptococcus was associated with infections in adult intravenous drug users, but not with pediatric pharyngitis. All emm92 strains were resistant to erythromycin and clindamycin.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Rheumatology
Joanna Perzynska-Mazan, Maria Maslinska, Robert Gasik
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Rheumatology
Ewa Wozniak-Roszkowska, Maria Maslinska, Piotr Gierej, Bartlomiej Noszczyk
RHEUMATOLOGY INTERNATIONAL
(2020)
Review
Rheumatology
Monika Dzwigala, Piotr Sobolewski, Maria Maslinska, Ida Yurtsever, Elzbieta Szymanska, Irena Walecka
Summary: Ultrasound is used in skin assessment of patients with systemic sclerosis to help with clinical evaluation of skin involvement, and it should be compared to skin biopsy. Currently, there is a lack of guidance for conducting skin measurements using ultrasound in patients, and the clinical use of skin imaging in systemic sclerosis is limited due to the lack of standard operating procedures.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Rheumatology
Maria Maslinska, Malgorzata Manczak, Brygida Kwiatkowska, Vince Ramsperger, Long Shen, Lakshmanan Suresh
Summary: The study found that RF-IgA showed the best diagnostic accuracy for pSS, closely associated with anti-SS-A/Ro and anti-SS-B antibodies, providing a helpful tool for establishing pSS diagnosis.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Beata Tarnacka, Anna Jopowicz, Maria Maslinska
Summary: Copper, manganese, and iron are essential elements for appropriate brain development and function, but their imbalance can lead to various neurological conditions. This review focuses on neurological disorders associated with excess copper, iron, and manganese, and discusses the diagnosis and potential treatment of these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Maria Maslinska, Joanna Dmowska-Chalaba, Michal Jakubaszek
Summary: The role of IgG4 in IgG4-RD and other autoimmune diseases has attracted attention. IgG4, as a unique subclass of immunoglobulins, is generally considered non-inflammatory and tolerance inducing, but in IgG4-RD, it may play a pathogenic role in fibrogenesis and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pawel Turczyn, Piotr Wojdasiewicz, Lukasz A. Poniatowski, Daryush Purrahman, Maria Maslinska, Grzegorz Zurek, Katarzyna Romanowska-Prochnicka, Beata Zuk, Brygida Kwiatkowska, Bartlomiej Piechowski-Jozwiak, Dariusz Szukiewicz
Summary: This study evaluates potential reasons for the oversight of omega-3 fatty acid therapy in the treatment and prevention of spinal cord injury. The current research results are inconclusive, but not fully utilizing the potential properties of omega-3 fatty acids due to methodological difficulties might be a potential waste.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Immunology
Maria Maslinska, Kinga Kostyra-Grabczak
Summary: Primary Sjogren's syndrome is an autoimmune disease that affects exocrine glands and internal organs. Viral infections are one of the risk factors for its development, as viruses can influence the immune system and initiate autoimmune reactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Laura Naranjo, Ljudmila Stojanovich, Aleksandra Djokovic, Laura Andreoli, Angela Tincani, Maria Mslinska, Savino Sciascia, Maria Infantino, Sara Garcinuno, Kinga Kostyra-Grabczak, Mariangela Manfredi, Francesca Regola, Natasa Stanisavljevic, Milomir Milanovic, Jovica Saponjski, Dario Roccatello, Irene Cecchi, Massimo Radin, Maurizio Benucci, Daniel Pleguezuelo, Manuel Serrano, Yehuda Shoenfeld, Antonio Serrano
Summary: The aim of this multicenter, cross-sectional and observational study was to evaluate the association between the presence of circulating immune complexes (CIC) formed by beta-2-glycoprotein-I (B2GP1) and anti-B2GP1 antibodies (B2-CIC) and clinical manifestations in patients with antiphospholipid syndrome (APS). The results showed that patients with thrombotic events and positive for B2-CIC had lower platelet count and complement levels, suggesting a greater degree of platelet activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Rheumatology
Jose Hernandez-Rodriguez, Jakub Niescieruk, Maria Maslinska
Article
Immunology
Marta Swiecka, Maria Maslinska
Summary: Liquid biopsy is a rapidly evolving diagnostic technique that analyzes tissue-derived information in blood or other bodily fluids. It has the potential to guide therapeutic decisions and has been applied in autoimmune rheumatic diseases.
CRITICAL REVIEWS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Marta Swiecka, Lukasz Paluch, Piotr Pietruski, Maria Maslinska, Jakub Zakrzewski, Brygida Kwiatkowska
Summary: The primary aim of this study was to verify if shear wave elastography can be used to evaluate salivary gland involvement in primary Sjogren's syndrome (pSS). It was confirmed that shear wave elastography measurement of salivary glands has strong predictive ability in pSS detection.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Immunology
Maria Maslinska, Kinga Kostyra-Grabczak, Leszek Krolicki, Brygida Kwiatkowska
Summary: The human microbiome is an ecosystem within the host organism, and dysbiosis may lead to immune system activation and development of autoimmune diseases. Changes in the microbiome play a significant role in diseases like Sjogren's syndrome, and understanding this influence may help prevent symptom progression.
CRITICAL REVIEWS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Ciro Manzo, Maria Maslinska, Alberto Castagna, Elvis Hysa, Alfonso Merante, Marcin Milchert, Tiziana Gravina, Betul Sargin, Maria Natale, Carmen Ruberto, Giovanni Ruotolo
Summary: The association between AMA, PBC, and PMR/GCA is rare, with only one biopsy-proven PBC case reported in a patient with PMR/GCA. The link between PMR/GCA and autoimmune rheumatic diseases in which PBC is relatively common is anecdotal.
MEDICINA-LITHUANIA
(2021)
Meeting Abstract
Rheumatology
M. Maslinska, A. Paradowska-Gorycka, A. Wajda, K. Kostyra-Grabczak, B. Kwiatkowska
ANNALS OF THE RHEUMATIC DISEASES
(2020)