期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 138, 期 -, 页码 26-44出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2014.03.004
关键词
Dermal fibroblasts; Extrinsic skin ageing; Mitochondrial dysfunction; DNA damage; Altered proteostasis; Cellular senescence
资金
- Deutsche Forschungsgemeinschaft [SFB 728, GK 1033, Re 3046/2-1, Kr 871/5-1]
- Human Frontier Science Program [CDA00009/2009-C]
- German Ministry of Research and Education
- UVA Strahlenschaden Network [OZNUK003]
Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage accumulation and (mal-)adaptation, thus constituting a powerful indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of ageing (Lopez-Otin et al., 2013, Cell 153) to categorise the available knowledge regarding dermal fibroblast ageing. We discriminate processes inducible in culture from phenomena apparent in skin biopsies or primary cells from old donors, coming to the following conclusions: (i) Fibroblasts aged in culture exhibit most of the established, ubiquitous hallmarks of ageing. (ii) Not all of these hallmarks have been detected or investigated in fibroblasts aged in situ (in the skin). (iii) Dermal fibroblasts aged in vitro and in vivo exhibit additional features currently not considered ubiquitous hallmarks of ageing. (iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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