期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 133, 期 4, 页码 147-156出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2012.03.009
关键词
DNA damage signaling; Oxidative stress; Base excision repair; Reactive oxygen species; Genome instability
资金
- Intramural NIH HHS Funding Source: Medline
- NIEHS NIH HHS [P01 ES011163-03, P01 ES011163-07, P01 ES011163-05, P01 ES011163-09, ES 011163, P01 ES011163-04, P01 ES011163-08, P01 ES011163, P01 ES011163-06A1] Funding Source: Medline
Activation of signaling pathways in response to genotoxic stress is crucial for cells to properly repair DNA damage. In response to DNA damage, intracellular levels of reactive oxygen species increase. One important function of such a response could be to initiate signal transduction processes. We have employed the model eukaryote Saccharomyces cerevisiae to delineate DNA damage sensing mechanisms. We report a novel, unanticipated role for the transcription factor Yap1 as a DNA damage responder, providing direct evidence that reactive oxygen species are an important component of the DNA damage signaling process. Our findings reveal an epistatic link between Yap1 and the DNA base excision repair pathway. Corruption of the Yap1-mediated DNA damage response influences cell survival and genomic stability in response to exposure to genotoxic agents. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据