Article
Biochemistry & Molecular Biology
Injeong Cho, Hyun-Ok Song, Ha Eun Ji, Sungtae Yang, Jeong Hoon Cho
Summary: BAM15 can reduce neuronal defects and neurodegeneration in aging C. elegans, potentially through mitochondrial uncoupling mechanism.
Article
Genetics & Heredity
Yao Zhu, Ying Li, Yuechen Wang, Liang Wang, Peng Shi, Xinze Du, Yingchun Zhang, Yuanjian Song, Zuobin Zhu
Summary: Variations in mitochondrial DNA (mtDNA) are associated with phenotypic traits and lifespan, and their regulatory mechanism involves retrograde communication between mitochondria and the nucleus. In Caenorhabditis elegans, the nuclear gene dct-15 interacts with natural variations in mtDNA COX1, affecting cellular function and lifespan.
Article
Pharmacology & Pharmacy
Wu Zeng, An Guo Wu, Xiao-Gang Zhou, Imran Khan, Rui Long Zhang, Hang Hong Lo, Li Qun Qu, Lin Lin Song, Xiao Yun Yun, Hui Miao Wang, Juan Chen, Jerome P. L. Ng, Fang Ren, Si Yu Yuan, Lu Yu, Yong Tang, Guo Xin Huang, Vincent Kam Wai Wong, Sookja Kim Chung, Simon Wing Fai Mok, Da Lian Qin, Hua Lin Sun, Liang Liu, W. L. Wendy Hsiao, Betty Yuen Kwan Law
Summary: With the increase in human lifespan, population aging has become a major global issue. Aging is an irreversible progressive process that affects humans through various factors. Traditional herbal plants have been widely used for anti-aging and modulation of aging-related symptoms due to their safety and polypharmacological potency.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Chaweewan Sirakawin, Dongfa Lin, Ziyue Zhou, Xiaoxin Wang, Rhianne Kelleher, Shangyuan Huang, Weimiao Long, Andre Pires-daSilva, Yu Liu, Jingjing Wang, Ilya A. Vinnikov
Summary: This study found that vitamin A can extend lifespan, reduce fat accumulation and lipofuscin production, and increase resistance to heat and oxidative stress in Caenorhabditis elegans. This resistance is attributed to the high levels of detoxifying enzymes induced by vitamin A. Additionally, the study found that vitamin A can upregulate the expression of related genes in human cells and mouse liver tissues.
Article
Biology
Osvaldo Villa, Nicole L. Stuhr, Chia-an Yen, Eileen M. Crimmins, Thalida Em Arpawong, Sean P. Curran
Summary: This study identifies the evolutionarily conserved mitochondrial enzyme ALH-6/ALDH4A1 as a predictive biomarker for age-related changes in muscle health. Through Caenorhabditis elegans genetics and gene-wide association scanning, the research uncovers that loss-of-function mutations in alh-6 lead to the age-dependent loss of muscle health in C. elegans, while genetic variants in ALDH4A1 show associations with age-related muscle-related function in humans.
Article
Cell Biology
Jing Tian, Caroline Geiss, Kim Zarse, Corina T. Madreiter-Sokolowski, Michael Ristow
Summary: Green tea catechins such as EGCG and ECG have been found to extend healthspan and lifespan in Caenorhabditis elegans by inhibiting mitochondrial complex I and temporarily lowering ATP levels, leading to activation of SKN-1 and DAF-16. These catechins also reduce fat content, enhance ROS defense, and ultimately improve overall healthspan through adaptive responses.
Article
Biology
Meng Huang, Minjie Hong, Xinhao Hou, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, Xuezhu Feng
Summary: The study identified a class of putative histone 3 lysine 9 mono/dimethyltransferase genes mutations that induce synergistic lifespan extension in Caenorhabditis elegans, increasing resistance to oxidative and heat stress, depending on the transcription factor DAF-16. Treatment with a specific inhibitor also resulted in similar effects.
Article
Multidisciplinary Sciences
Jihao Mo, Zhenzhen Zhang, Xiaowei Wang, Miaomiao Wang, Ning Sun, Lei Wang, Meimei Wang
Summary: A high glucose diet extends the lifespan of aged worms dependent on oxidative stress resistance. The highly expressed genes gpdh-1 and col-92 are associated with oxidative stress response in worms fed high glucose diet. Intestinal gpdh-1 is essential for the lifespan extension induced by high glucose diet in aged worms.
Article
Biotechnology & Applied Microbiology
Yiling Yang, Wenbin Wang, Kefeng Liu, Jie Zhao
Summary: This study developed an antioxidant nanosystem (SOD@MSN) by immobilizing SOD on mesoporous silica nanoparticles (MSNs) and conducted anti-aging experiments using the nematode model. The results showed that SOD@MSN could be effectively internalized by the nematode and protect it against external stress, thus extending its lifespan and healthspan.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Nicholas D. Urban, Joseph P. Cavataio, Yasmeen Berry, Brandon Vang, Anirudh Maddali, Richard J. Sukpraphrute, Santiago Schnell, Matthias C. Truttmann
Summary: The nematode Caenorhabditis elegans is widely used for studying various biological processes, but differences in experimental conditions and variations in chemical treatments or geographic locations can significantly influence the lifespan of N2 worms, leading to unreliable inter-laboratory comparisons. Standardized experimental protocols and improved reporting standards are needed to increase the reliability and reproducibility of lifespan studies in C. elegans.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Cell Biology
Sonja K. Soo, Zenith D. Rudich, Bokang Ko, Alibek Moldakozhayev, Abdelrahman AlOkda, Jeremy M. Van Raamsdonk
Summary: While aging was once considered as a stochastic process of damage accumulation, recent studies have shown that genetics plays a significant role in the aging process. Long-lived genetic mutants in model organisms have provided insights into the genetic and molecular mechanisms involved in extending lifespan. These mutants exhibit activation of stress response pathways, leading to enhanced resistance to stressors, and lifespan exhibits a positive correlation with stress resistance. Disruption of stress response pathways inhibits lifespan extension in these mutants and also reduces lifespan in normal animals, indicating the crucial role of stress response pathways in determining lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Jia-Ping Ke, Jing-Ya Yu, Biao Gao, Feng-Lin Hu, Feng-Qing Xu, Guangmin Yao, Guan-Hu Bao
Summary: Two new catechins, zijuanins E and F, were isolated and identified from Zijuan green tea. These compounds were found to prolong the lifespan of Caenorhabditis elegans, enhance stress resistance, and reduce oxidative stress. They also exhibited strong antioxidant activity and binding ability to human serum albumin.
Article
Biochemistry & Molecular Biology
Lei Zhou, Jin Liu, Lan-Lan Bu, Duan-Fang Liao, Shao-Wu Cheng, Xi-Long Zheng
Summary: The novel compound curcumin acetylsalicylate (CA) was found to extend the lifespan of Caenorhabditis elegans in a dose-dependent manner, decrease oxidative stress, and increase the expression of antioxidative genes. Activation of the DAF-16 transcription factor by CA may contribute to delaying aging in C. elegans.
Article
Pharmacology & Pharmacy
Ganlan Zhang, Hui Liu, Ting Xue, Xiangming Kong, Dongmei Tian, Libo Luo, Yanhua Yang, Keqing Xu, Youheng Wei, Ziheng Zhuang
Summary: Aging is a process of degenerative changes that cause diseases and disabilities. Research aims to find drugs that can extend lifespan and treat age-related diseases. Ribavirin has been discovered as a potential drug for aging intervention by inhibiting TOR signaling and activating AMPK. Its anti-aging effect is mediated via AMPK-TOR signaling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui
Summary: This study found that the natural non-nutritive sweetener Reb A can extend the lifespan and healthspan of C. elegans by reducing cellular reactive oxygen species levels and attenuating neutral lipid accumulation with aging. Reb A acts as an effective cellular antioxidant and lowers the ectopic accumulation of neutral lipids, which contributes to its anti-aging effects.