Article
Biochemistry & Molecular Biology
Paula Aguilera, Marion Dubarry, Julien Hardy, Michael Lisby, Marie-Noelle Simon, Vincent Geli
Summary: In yeast cells, C-circles bind to the nuclear pore complex (NPC) and the SAGA-TREX2 complex, promoting the formation of type II survivors. Disrupting the SAGA/TREX2 complex and the nuclear diffusion barrier affects telomere recombination.
Article
Biochemistry & Molecular Biology
Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L. Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A. Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D. Pavelko, David Dolan, Helen L. Reeves, Sushma Grellscheid, Colin H. Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L. Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamar Tchkonia, James L. Kirkland, Diana Jurk, Derek A. Mann, Joao F. Passos
Summary: The research shows that neutrophils cause oxidative damage to telomeres in non-immune cells, promoting cellular senescence. In aged liver, senescent cells recruit neutrophils, potentially leading to the spread of senescence.
Article
Cell Biology
Samuel I. Bloom, Yu Liu, Jordan R. Tucker, Md Torikul Islam, Daniel R. Machin, Hossein Abdeahad, Tyler G. Thomas, R. Colton Bramwell, Lisa A. Lesniewski, Anthony J. Donato
Summary: In advanced age, oxidative stress and inflammation increase and impair endothelial function, leading to cardiovascular disease (CVD). Senescent endothelial cells are a possible source of this oxidative stress and inflammation. In this study, reducing the telomere shelterin protein Trf2 in young mice resulted in endothelial cell telomere dysfunction, cellular senescence, increased inflammatory signaling, oxidative stress, and impairments in endothelial function. These findings suggest that age-related telomere dysfunction leads to endothelial cell senescence, contributing to age-related increases in oxidative stress, inflammation, and cardiovascular dysfunction.
Article
Cell Biology
Mikolaj Ogrodnik, Shane A. Evans, Edward Fielder, Stella Victorelli, Patrick Kruger, Hanna Salmonowicz, Bettina M. Weigand, Ayush D. Patel, Tamar Pirtskhalava, Christine L. Inman, Kurt O. Johnson, Stephanie L. Dickinson, Azucena Rocha, Marissa J. Schafer, Yi Zhu, David B. Allison, Thomas von Zglinicki, Nathan K. LeBrasseur, Tamar Tchkonia, Nicola Neretti, Joao F. Passos, James L. Kirkland, Diana Jurk
Summary: Clearing senescent cells, either through drug treatment or senolytic cocktail, has been shown to improve cognitive function, providing proof-of-concept for senolytic interventions as a potential therapeutic avenue for alleviating age-associated cognitive impairment.
Article
Biochemistry & Molecular Biology
Xupeng Yu, Sean Gray, Helder C. Ferreira
Summary: The POT-3 protein in Caenorhabditis elegans is found to bind the telomeric G-strand and affects telomere length and telomeric C-circle formation, showing differences with the closely related POT-2 protein in terms of binding sites and function.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Geriatrics & Gerontology
Emma Naomi James, Virag Sagi-Kiss, Mark Bennett, Maria Elzbieta Mycielska, Lee Peng Karen-Ng, Terry Roberts, Sheila Matta, Inderjeet Dokal, Jacob Guy Bundy, Eric Kenneth Parkinson
Summary: The study found that there is a connection between plasma metabolite signatures and aging-related diseases, in particular with DKC1-related diseases and telomere dysfunction. However, other TCA metabolites, lactate, and pyruvate clearly distinguish DKC1 patients from normal individuals. These findings have important implications for early diagnosis of aging and the development of anti-aging therapeutics.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Barbara Jacczak, Blazej Rubis, Ewa Toton
Summary: The stability of telomeres is crucial for cell function, and research on telomere biology and telomerase activity has been of great interest in various medical and scientific fields. Maintaining optimal telomere length and telomerase activity is an important step in anti-aging strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ion Udroiu, Jessica Marinaccio, Antonella Sgura
Summary: Telomere length can be maintained by either telomerase enzyme or telomeric recombination, but both mechanisms are inactive in most human somatic cells. ATRX has been identified as an ALT repressor gene, and TP53 is deficient in most ALT cell lines. This study found that p53 inhibits telomeric recombination, while ATRX inhibition increases telomeric recombination.
Review
Biochemistry & Molecular Biology
Alexey Yu Lupatov, Konstantin N. Yarygin
Summary: This review discusses the relationship between stem cells and cell aging, focusing on the telomere-centric theory. The impact of telomere shortening on the functional activity, aging, and potential use in cell therapy of different types of stem cells is discussed.
Article
Biochemistry & Molecular Biology
Simone Carrino, Christopher D. Hennecker, Ana C. Murrieta, Anthony Mittermaier
Summary: Human chromosomes have long, single-stranded DNA overhangs with repetitive sequences (TTAGGG)n at the termini, which can fold into guanine quadruplexes (GQ). The folding of GQs within these chains is influenced by folding frustration and negative cooperativity, leading to increased unfolding of TTAGGG repeats and potential binding sites for telomeric proteins. This phenomenon is particularly pronounced at the chain termini, suggesting a role in telomere extension by telomerase.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Oncology
Gustavo Borges, Melanie Criqui, Lea Harrington
Summary: Telomere maintenance is crucial for the integrity of both normal and cancer cells. The instability of telomeres can lead to genome instability in cancer and aging, but cancer cells can partially overcome this instability by increasing telomerase expression.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Jun Liu, Xiaojing Hong, Lihui Wang, Chao-Ya Liang, Jun-Ping Liu
Summary: Telomere shortening leads to cellular senescence, and this study reveals a dual opposing control mechanism of sub-telomeric Y' element recombination by Sir3/4 and Rif1, regulating telomere length and cell senescence in yeast Saccharomyces cerevisiae. Sir4 repression of Y' element recombination is negatively regulated by Rif1, mediating senescence-evasion induced by Sir4 deficiency.
Article
Cell & Tissue Engineering
Xingyu Gao, Xiao Yu, Chang Zhang, Yiming Wang, Yanan Sun, Hui Sun, Haiying Zhang, Yingai Shi, Xu He
Summary: Cellular senescence is closely related to the development of age-related diseases, and metabolic imbalance caused by short telomeres and mitochondrial damages play a significant role. Future studies on telomere and mitochondrial metabolism may provide potential therapeutic strategies for age-related diseases.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yilin Ying, Xuefei Hu, Peng Han, Aaron Mendez-Bermudez, Serge Bauwens, Rita Eid, Li Tan, Melanie Pousse, Marie-Joseph Giraud-Panis, Yiming Lu, Eric Gilson, Jing Ye
Summary: The shelterin protein complex plays a crucial role in telomere protection in eukaryotic organisms. In this study, researchers discovered that the zebrafish ortholog of TRF2, encoded by the terfa gene, protects against unwanted ATM activation throughout the genome. The loss of terfa results in prominent embryonic neurodevelopmental failure and premature aging in heterozygous fish. Restoring the expression of TRF2 in glial cells rescues the embryonic neurodevelopmental phenotype.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D. Ulrich, Dennis Kappei, Rene F. Ketting, Falk Butter
Summary: Telomeres are protected and regulated by specific proteins, with TEBP-1 and TEBP-2 identified as important players in these processes. Despite being paralogs, they have distinct effects on telomere dynamics. Additionally, TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
S. Giordano, A. Proietti, T. Bisaccia, P. Caso, A. Martocchia, P. Falaschi, L. Tafaro
OSTEOPOROSIS INTERNATIONAL
(2018)
Article
Geriatrics & Gerontology
A. Amici, A. Baratta, A. Linguanti, G. Giudice, A. Servello, C. Scalise, L. Tafaro, P. Cicconetti, V. Marigliano, M. Cacciafesta
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2008)
Article
Geriatrics & Gerontology
A. Martocchia, I. Indiano, L. Tafaro, P. Frugoni, A. Amici, M. Cacciafesta, V. Marigliano, P. Falaschi
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2009)
Article
Geriatrics & Gerontology
Laura Tafaro, Maria Teresa Tombolillo, Nina Bruekner, Giovanni Troisi, Paolo Cicconetti, Massimo Motta, Elisabeth Cardillo, Ettore Bennati, Vincenzo Marigliano
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2009)
Article
Geriatrics & Gerontology
A. Martocchia, P. Frugoni, I. Indiano, L. Tafaro, F. Comite, A. Amici, M. Cacciafesta, V. Marigliano, P. Falaschi
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2013)
Article
Geriatrics & Gerontology
Giulio Pioli, A. Barone, C. Mussi, L. Tafaro, G. Bellelli, P. Falaschi, M. Trabucchi, G. Paolisso
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2014)
Article
Clinical Neurology
Paolo Cicconetti, Veronica Ciotti, Laura Tafaro, Evaristo Ettorre, Flavia Chiarotti, Carolina Priami, Mauro Cacciafesta, Vincenzo Marigliano
CLINICAL NEUROPHYSIOLOGY
(2007)
Article
Business, Finance
V Marigliano, L Tafaro, I Trani
GENEVA PAPERS ON RISK AND INSURANCE-ISSUES AND PRACTICE
(2003)
Article
Geriatrics & Gerontology
L. Tafaro, P. Cicconetti, A. Baratta, N. Brukner, E. Ettorre, V. Marigliano, M. Cacciafesta
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2007)
Article
Geriatrics & Gerontology
P. Cicconetti, C. Priami, C. Sagrafoli, L. Tafaro, E. Ettorre, C. Donadio, M. Cacciafesta, V. Marigliano
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2007)
Article
Geriatrics & Gerontology
L Tafaro, P Cicconetti, G Tedeschi, A Baratta, R Ursino, E Ettorre, V Marigliano
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2004)
Article
Geriatrics & Gerontology
P Cicconetti, M Costarella, A Moise, V Ciotti, L Tafaro, G Monteforte, G Piccirillo, M Cacciafesta
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2004)
Article
Geriatrics & Gerontology
L Tafaro, P Cicconetti, G Zannino, G Tedeschi, MT Tombolillo, E Ettore, V Marigliano
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2002)
Article
Geriatrics & Gerontology
S Martella, P Cicconetti, L Tafaro, G Zannino, G Tedeschi, A Lorido, F Tombesi, IC Raffi, V Marigiliano
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2002)