Review
Biochemistry & Molecular Biology
Donatella Coradduzza, Antonella Congiargiu, Zhichao Chen, Angelo Zinellu, Ciriaco Carru, Serenella Medici
Summary: Senescence is a cellular aging process that contributes to the development of age-related complications, while ferroptosis is linked to various disorders. Both pathways play complex roles in aging and disease and require further research for a better understanding and potential interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yustina M. Puspitasari, Stefano Ministrini, Lena Schwarz, Caroline Karch, Luca Liberale, Giovanni G. Camici
Summary: The improvements in healthcare services and quality of life are leading to a longer life expectancy, resulting in a larger population of elderly individuals who are more susceptible to age-related cardiovascular diseases. Inflammation has been recognized as a key factor in the pathogenesis of cardiovascular diseases, suggesting that inflamm-aging could potentially be a driver of age-related cardiovascular afflictions and a viable therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Claudia Magrin, Martina Bellafante, Martina Sola, Ester Piovesana, Marco Bolis, Luciano Cascione, Sara Napoli, Andrea Rinaldi, Stephanie Papin, Paolo Paganetti
Summary: In this study, we performed a bioinformatics analysis to better understand the possible role of Tau in regulation of chromatin compaction and gene expression. Our findings suggest that Tau depletion leads to deregulation of transcripts involved in the polycomb repressive complex 2, leading to decreased levels of core components of the complex and lower histone 3 trimethylation. These changes are associated with increased senescence induction in Tau-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gabor Czibik, Zaineb Mezdari, Dogus Murat Altintas, Juliette Brehat, Maria Pini, Thomas d'Humieres, Thais Delmont, Costin Radu, Marielle Breau, Hao Liang, Cecile Martel, Azania Abatan, Rizwan Sarwar, Ophelie Marion, Suzain Naushad, Yanyan Zhang, Maissa Halfaoui, Nadine Suffee, Didier Morin, Serge Adnot, Stephane Hatem, Arash Yavari, Daigo Sawaki, Genevieve Derumeaux
Summary: The study found that aging myocardium leads to elevated plasma levels of the essential amino acid phenylalanine, contributing to cardiac dysfunction. Inhibition of p21 gene can delay this process. Phenylalanine treatment induces premature cardiac deterioration, but this can be reversed through pharmacological or dietary interventions.
Article
Veterinary Sciences
Jessica Quimby, Andrea Erickson, Shannon Mcleland, Rachel Cianciolo, David Maranon, Katharine Lunn, Jonathan Elliott, Jack Lawson, Ann Hess, Rene Paschall, Susan Bailey
Summary: This study found significantly increased renal cell senescence, telomere shortening, and nitrosative stress in cats with CKD, suggesting that these patients may benefit from senolytic therapy.
VETERINARY SCIENCES
(2021)
Article
Geriatrics & Gerontology
Chun-Sun Jiang, Tapasi Rana, Lee-Way Jin, Susan A. Farr, John E. Morley, Hongwei Qin, Gang Liu, Rui-Ming Liu
Summary: The exact cause of late-onset Alzheimer's disease (LOAD) is still unknown, but there is evidence suggesting that cellular senescence plays an important role in its pathophysiology. This study found that the expression of plasminogen activator inhibitor 1 (PAI-1) is increased in the brain cells of LOAD patients and SAMP8 mice, along with the expression of cell cycle repressors p53 and p21. Further in vitro studies showed that PAI-1 overexpression induced senescence, while inhibition or silencing of PAI-1 attenuated senescence in astrocytes and reduced neuron apoptosis induced by senescent astrocytes.
Article
Cell Biology
Nynke Talma, Emma Gerrits, Boshi Wang, Bart J. L. Eggen, Marco Demaria
Summary: Cells expressing high levels of the CDK4/6 inhibitor p16 accumulate in aging tissues and promote age-related pathologies, particularly neurodegeneration. This study identifies two distinct subpopulations of p16-expressing microglia in the mouse brain, one associated with aging and one present in young animals, which could impact brain homeostasis, function, and disease positively or negatively.
Article
Cell Biology
Zeming Wu, Jie Ren, Guang-Hui Liu
Summary: N-6-methyladenosine (m6A) is a dynamic and reversible RNA modification that plays a crucial role in the life cycle of RNA and has gained attention for its potential involvement in aging and age-related diseases. This Perspective article provides a summary of the current advances in aging-related m6A regulation, highlighting the significant findings and their implications for our understanding of cellular senescence and aging, as well as the potential for targeting RNA m6A regulation as a therapeutic strategy. The article also discusses the limitations and challenges in this field and provides insights into future research directions.
Article
Gastroenterology & Hepatology
Adam S. Faye, Jean-Frederic Colombel
Summary: Recent epidemiological data suggests that patients with inflammatory bowel disease (IBD) are aging chronologically, leading to chronic inflammation and increased frailty, which are closely related to biological aging.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L. Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A. Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D. Pavelko, David Dolan, Helen L. Reeves, Sushma Grellscheid, Colin H. Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L. Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamar Tchkonia, James L. Kirkland, Diana Jurk, Derek A. Mann, Joao F. Passos
Summary: The research shows that neutrophils cause oxidative damage to telomeres in non-immune cells, promoting cellular senescence. In aged liver, senescent cells recruit neutrophils, potentially leading to the spread of senescence.
Review
Clinical Neurology
Michael Candlish, Jasmin K. Hefendehl
Summary: Microglia, the primary immune cells of the central nervous system, undergo an aging process that impairs their ability to perform vital functions. They transition from a homeostatic state to an activated state in response to insults and aging, showing diverse responses to stimuli such as acute injury or chronic disease. This complexity is further influenced by the distinct alterations that occur in the aging process.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cell Biology
Lena Guerrero-Navarro, Pidder Jansen-Durr, Maria Cavinato
Summary: Organismal aging is associated with an increase in senescent cells, which disrupt normal tissue function. Cellular organelle damage and lysosomal dysfunction are crucial factors in regulating cellular behavior during aging.
Review
Biochemistry & Molecular Biology
Erika Csekes, Lucia Rackova
Summary: This article discusses the impact of skin aging and cellular senescence on the skin, as well as the role of natural polyphenols in preventing and delaying aging. It also summarizes the latest research on the anti-senescent mechanisms of polyphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hong Wei, Yuhao Xu, Li Lin, Yuefeng Li, Xiaolan Zhu
Summary: In summary, this review summarizes the current understanding of the influence of RNA modification on cellular senescence, with a focus on mRNA methylation in aging-related diseases, and discusses the emerging potential of RNA modification in diagnosis and therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Article
Endocrinology & Metabolism
Nicole M. Ashpole, Jacquelyn C. Herron, Matthew C. Mitschelen, Julie A. Farley, Sreemathi Logan, Han Yan, Zoltan Ungvari, Erik L. Hodges, Anna Csiszar, Yuji Ikeno, Mary Beth Humphrey, William E. Sonntag
JOURNAL OF BONE AND MINERAL RESEARCH
(2016)
Article
Geriatrics & Gerontology
Ferenc Deak, Willard M. Freeman, Zoltan Ungvari, Anna Csiszar, William E. Sonntag
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2016)
Article
Geriatrics & Gerontology
Nicole M. Ashpole, Jacquelyn C. Herron, Patrick N. Estep, Sreemathi Logan, Erik L. Hodges, Andriy Yabluchanskiy, Mary Beth Humphrey, William E. Sonntag
Article
Geriatrics & Gerontology
Stefano Tarantini, Cory B. Giles, Jonathan D. Wren, Nicole M. Ashpole, M. Noa Valcarcel-Ares, Jeanne Y. Wei, William E. Sonntag, Zoltan Ungvari, Anna Csiszar
Article
Geriatrics & Gerontology
Stefano Tarantini, Zsuzsanna Tucsek, M. Noa Valcarcel-Ares, Peter Toth, Tripti Gautam, Cory B. Giles, Praveen Ballabh, Jeanne Y. Wei, Jonathan D. Wren, Nicole M. Ashpole, William E. Sonntag, Zoltan Ungvari, Anna Csiszar
Article
Biochemistry & Molecular Biology
Dongmei Zhang, M. Caleb Marlin, Zhimin Liang, Mohiuddin Ahmad, Nicole M. Ashpole, William E. Sonntag, Zhizhuang Joe Zhao, Guangpu Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Geriatrics & Gerontology
Colleen A. Mangold, Dustin R. Masser, David R. Stanford, Georgina V. Bixler, Aditya Pisupati, Cory B. Giles, Jonathan D. Wren, Matthew M. Ford, William E. Sonntag, Willard M. Freeman
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Clinical Neurology
T. David Luo, Timothy B. Alton, Peter J. Apel, Jiaozhong Cai, Jonathan C. Barnwell, William E. Sonntag, Thomas L. Smith, Zhongyu Li
Article
Genetics & Heredity
Niran Hadad, Dustin R. Masser, Sreemathi Logan, Benjamin Wronowski, Colleen A. Mangold, Nicholas Clark, Laura Otalora, Archana Unnikrishnan, Matthew M. Ford, Cory B. Giles, Jonathan D. Wren, Arlan Richardson, William E. Sonntag, David R. Stanford, Willard Freeman
EPIGENETICS & CHROMATIN
(2016)
Article
Biochemistry & Molecular Biology
Blake R. Hopiavuori, Martin-Paul Agbaga, Richard S. Brush, Michael T. Sullivan, William E. Sonntag, Robert E. Anderson
JOURNAL OF LIPID RESEARCH
(2017)
Article
Surgery
Andrew W. Gardner, Polly S. Montgomery, Yan D. Zhao, Federico Silva-Palacios, Zoltan Ungvari, Anna Csiszar, William E. Sonntag
JOURNAL OF VASCULAR SURGERY
(2017)
Article
Geriatrics & Gerontology
Nicole M. Ashpole, Sreemathi Logan, Andriy Yabluchanskiy, Matthew C. Mitschelen, Han Yan, Julie A. Farley, Erik L. Hodges, Zoltan Ungvari, Anna Csiszar, Sixia Chen, Constantin Georgescu, Gene B. Hubbard, Yuji Ikeno, William E. Sonntag
Article
Geriatrics & Gerontology
Andrej Podlutsky, Marta Noa Valcarcel-Ares, Krysta Yancey, Viktorija Podlutskaya, Eszter Nagykaldi, Tripti Gautam, Richard A. Miller, William E. Sonntag, Anna Csiszar, Zoltan Ungvari
Article
Biochemistry & Molecular Biology
Eileen E. Parks, Sreemathi Logan, Alexander Yeganeh, Julie A. Farley, Daniel B. Owen, William E. Sonntag
JOURNAL OF LIPID RESEARCH
(2020)
Article
Cell Biology
Stefano Tarantini, Noa M. Valcarcel-Ares, Andriy Yabluchanskiy, Zsolt Springo, Gabor A. Fulop, Nicole Ashpole, Tripti Gautam, Cory B. Giles, Jonathan D. Wren, William E. Sonntag, Anna Csiszar, Zoltan Ungvari