Article
Medicine, General & Internal
Waichan Lok, Jiapeng Zhang, Xiaonan Zheng, Tianhai Lin, Hang Xu, Ping Tan, Qiang Wei
Summary: This study aimed to compare the survival outcomes between patients with primary muscle-invasive bladder cancer (PMIBC) and secondary non-muscle-invasive bladder cancer that progresses into muscle-invasive bladder cancer (SMIBC) in China. The results showed that SMIBC had worse survival outcomes once it became muscle-invasive compared to PMIBC. Therefore, specific attention should be given to non-muscle-invasive bladder cancer patients with a high progression risk.
CHINESE MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Zhenjun Yu, Yu Zhang, Yingying Cao, Manman Xu, Shaoli You, Yu Chen, Bing Zhu, Ming Kong, Fangjiao Song, Shaojie Xin, Zhongping Duan, Tao Han
Summary: The study aimed to establish and validate a new scoring system to predict short-term prognosis in patients with acute-on-chronic liver failure using baseline and dynamic data. The new model, based on clinical data, showed better prognostic ability than current scoring systems.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Olga Novosad, Tymur Rudiuk, Lesya Shevchuk, Viktoriia Kundina, Anna Schmidt
Summary: This study presents the clinical experience of a patient with cardiac amyloidosis associated with multiple myeloma. Magnetic resonance imaging confirmed the signs of cardiac amyloidosis and the patient achieved a good outcome with appropriate treatment.
Article
Immunology
Giuseppe Cullaro, Elizabeth C. Verna, Jean C. Emond, Babak J. Orandi, Sumit Mohan, Jennifer C. Lai
Summary: Based on analysis of the UNOS database, simultaneous liver-kidney transplantation (SLKT) poses a higher risk of kidney allograft failure (KF) for patients with an end-stage liver disease (MELD) score of >= 25, compared to kidney transplant after liver transplant (KALT). With the establishment of the Safety Net, KALT may offer an opportunity to improve kidney outcomes for patients with an MELD >= 25.
Article
Rheumatology
Julia Chernis, Maryam Buni, Sarah Kazzaz, Jun Ying, Marka Lyons, Shervin Assassi, Maureen Mayes
Summary: This study is a large longitudinal study of early disease SSc patients, and it found that the severity of skin disease and socioeconomic factors such as educational level and income are important predictors of perceived functional disability in SSc.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soonwook Kwon, Woo Kyo Jeong, Ji-Hyung Park, Juhyun Kim, Eun Bin Cho, Jin Myoung Seok, Seok Jin Kim, Kihyun Kim, Eun-Seok Jeon, Ju-Hong Min, Byoung Joon Kim
Summary: This study investigated the predictive role of autonomic dysfunction in prognosis of patients with light-chain (AL) amyloidosis. The results showed that autonomic dysfunction was observed in 96% of AL amyloidosis patients, and the use of autonomic function test could predict the survival rate of patients.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2022)
Article
Rheumatology
Majd Bairkdar, Enoch Yi-Tung Chen, Paul W. Dickman, Roger Hesselstrand, Helga Westerlind, Marie Holmqvist
Summary: This study conducted a nationwide cohort study to investigate the survival patterns of patients with incident systemic sclerosis (SSc) in Sweden. The results showed that the survival rate of SSc patients diagnosed between 2004 and 2015 was significantly lower compared to the general population, despite advances in understanding and diagnosing the disease.
Article
Oncology
Eli Muchtar, Angela Dispenzieri, Brendan Wisniowski, Giovanni Palladini, Paolo Milani, Giampaolo Merlini, Stefan Schoenland, Kaya Veelken, Ute Hegenbart, Susan M. Geyer, Shaji K. Kumar, Efstathios Kastritis, Meletios A. Dimopoulos, Michaela Liedtke, Ronald Witteles, Vaishali Sanchorawala, Raphael Szalat, Heather Landau, Erica Petrlik, Suzanne Lentzsch, Alexander Coltoff, Joan Blade, Maria Teresa Cibeira, Oliver Cohen, Darren Foard, Ashutosh Wechalekar, Morie A. Gertz
Summary: This study validates the use of graded cardiac response criteria using N-terminal prohormone of brain natiuretic peptide/brain natiuretic peptide as indicators. The results show that deeper cardiac response is significantly associated with better survival, and the four-level response performs better than the two-level response in assessing cardiac improvement. Early diagnosis plays an important role in achieving deep cardiac responses.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Kata Joo, Annamaria Nemes, Beata Dudas, Eva Berkes-Bara, Akos Murber, Janos Urbancsek, Peter Fancsovits
Summary: Cytoplasmic strings in human in vitro fertilised embryos are correlated with embryo viability, regardless of the fertilisation method. Embryos with cytoplasmic strings reach the blastocyst stage earlier and have better morphokinetic parameters. The examination of this feature may aid in decision-making regarding embryos with higher implantation potential.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chingching Foocharoen, Wilaiphorn Thinkhamrop, Nathaphop Chaichaya, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Bandit Thinkhamrop
Summary: This study aimed to develop and validate a simple predictive model for predicting mortality among patients with systemic sclerosis (SSc). The results showed that the model using the modified Rodnan skin score (mRSS) and WHO-FC as predictive factors performed the best in mortality prediction.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Jie Xie, Xu Xiao, Zhenjia Dong, Qiangdong Wang
Summary: This study evaluated the association between systemic inflammation score (SIS) and clinicopathological features of prostate cancer (PCa), and found that a high SIS is associated with unfavorable survival. SIS serves as an independent prognostic factor for overall survival (OS) in patients with PCa.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Filip Tichanek, Asta Foersti, Vaclv Liska, Otto Hemminki, Anni Koskinen, Akseli Hemminki, Kari Hemminki
Summary: This study analyzed the long-term survival of thyroid cancer patients in Denmark, Finland, Norway, and Sweden from 1971 to 2020. The 1-year survival rate was lower than the 5/1-year survival rate, but the difference decreased over time. The overall survival of thyroid cancer patients increased over the 50-year period, with 5-year survival rates close to 90% for men and close to 95% for women. Incidence rates increased significantly, while mortality rates decreased.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Otto Szenci
Summary: Pregnancy diagnosis is crucial in dairy farms for reducing days open, with traditional and new methods available in the field. Accuracy is key before introducing new diagnostic tests to minimize iatrogenic pregnancy losses. Techniques like B-mode ultrasonography and biomarkers show promise for early pregnancy detection, but further development is needed.
Review
Oncology
Peter Dubsky, Katja Pinker, Fatima Cardoso, Giacomo Montagna, Mathilde Ritter, Carsten Denkert, Isabel T. Rubio, Evandro de Azambuja, Giuseppe Curigliano, Oreste Gentilini, Michael Gnant, Andreas Guenthert, Nik Hauser, Joerg Heil, Michael Knauer, Mona Knotek-Roggenbauerc, Susan Knox, Tibor Kovacs, Henry M. Kuerer, Sibylle Loibl, Meinrad Mannhart, Icro Meattini, Frederique Penault-Llorca, Nina Radosevic-Robin, Patrizia Sager, Tanja Spanic, Petra Steyerova, Christoph Tausch, Marie-Jeanne T. F. D. Vrancken Peeters, Walter P. Weber, Maria J. Cardoso, Philip Poortmans
Summary: An international consortium was established to provide clinical guidance and tools for the technical management of patients with early-stage breast cancer through discussions and consensus meetings. During the meeting, 42% of statements reached a consensus, 38% were supported by the majority, and 21% did not reach a decision.
Article
Hematology
Sriram Ravichandran, Shameem Mahmood, Brenden Wisniowski, Sajitha Sachchithanantham, Rakesh Popat, Helen Lachmann, Neil Rabin, Karthik Ramasamy, Stephen Hawkins, Charalampia Kyriakou, Julian Gillmore, Kwee Yong, Philip Hawkins, Graham Jackson, Guy Pratt, Ashutosh D. Wechalekar
Summary: This study found that depth of response is critical in the prognosis of AL amyloidosis. By analyzing patients' baseline characteristics and 1-month response, those unlikely to improve treatment response can be identified. It is recommended that patients with a significant difference in involved and uninvolved serum free light chains at diagnosis and no response at 1 month switch treatment early.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Aldo A. Acosta-Medina, Ann M. Moyer, Ronald S. Go, Maria Alice V. Willrich, Fernando C. Fervenza, Nelson Leung, Christianne Bourlon, Jeffrey L. Winters, Grant M. Spears, Sandra C. Bryant, Meera Sridharan
Summary: Eculizumab is effective for complement-mediated thrombotic microangiopathy. Discontinuation of therapy does not universally lead to relapse. This study aimed to assess the role of complement genetic variants in predicting recurrence after Eculizumab withdrawal. A total of 280 patients were included, with CFH and MCP/CD46 being the most commonly identified genetic variants. The relapse rate after discontinuation was 29.6%, with CFH and MCP/CD46 variants in canonical splice regions having the highest relapse rates.
Article
Hematology
Matthew Ho, Saurabh Zanwar, Francis K. Buadi, Sikander Ailawadhi, Jeremy Larsen, Leif Bergsagel, Moritz Binder, Asher Chanan-Khan, David Dingli, Angela Dispenzieri, Rafael Fonseca, Morie A. Gertz, Wilson Gonsalves, Ronald S. Go, Suzanne Hayman, Prashant Kapoor, Taxiarchis Kourelis, Martha Q. Lacy, Nelson Leung, Yi Lin, Eli Muchtar, Vivek Roy, Taimur Sher, Rahma Warsame, Amie Fonder, Miriam Hobbs, Yi L. Hwa, Robert A. Kyle, S. Vincent Rajkumar, Shaji Kumar
Summary: Patients with multiple myeloma have a lower efficacy from COVID-19 vaccination and a high rate of mortality from COVID-19 in hospitalized patients. The study found a relatively low infection rate but a quarter of the COVID-19 infections were severe. Treatment with CD38 antibody, cardiac and pulmonary comorbidities were independent predictors for ICU admission. Cardiac comorbidity was an independent predictor of mortality, while MM/AL in remission was associated with lower mortality.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Marco Dicanio, Matteo Giaccherini, Alyssa Clay-Gilmour, Angelica Macauda, Juan Sainz, Mitchell J. Machiela, Malwina Rybicka-Ramos, Aaron D. Norman, Agata Tyczynska, Stephen J. Chanock, Torben Barington, Shaji K. Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E. Brown, Anna Suska, Eva K. Haastrup, Robert Z. Orlowski, Marek Dudzinski, Ramon Garcia-Sanz, Marcin Kruszewski, Joaquin Martinez-Lopez, Katia Beider, Elzbieta Iskierka-Jazdzewska, Matteo Pelosini, Sonja Berndt, Malgorzata Razny, Krzysztof Jamroziak, S. Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N. Hofmann, Mario Petrini, Aleksandra Butrym, Susan L. Slager, Elad Ziv, Edyta Subocz, Graham G. Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A. T. Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Varkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd-Sitek, Xifeng Wu, Katalin Kadar, Nicola J. Camp, Norbert Grzasko, Rosalie G. Waller, Celine Vachon, Federico Canzian, Daniele Campa
Summary: The aim of this study was to identify novel pleiotropic variants involved in multiple myeloma (MM) risk. Through analysis of 28,684 single nucleotide polymorphisms (SNPs), DNAJB4-rs34517439-A was found to be associated with an increased risk of developing MM.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Hematology
Karan L. Chohan, Jonas Paludo, Nishanth Vallumsetla, Dirk Larson, Rebecca L. King, Rong He, Wilson Gonsalves, David Inwards, Thomas E. Witzig, Abhisek Swaika, Tania Jain, Nelson Leung, Sikander Ailawadhi, Craig B. Reeder, Martha Q. Lacy, S. Vincent Rajkumar, Shaji Kumar, Robert A. Kyle, Morie A. Gertz, Stephen M. Ansell, Prashant Kapoor
Summary: Waldenstrom macroglobulinemia (WM) is a rare, indolent lymphoma that mostly affects the elderly. A study compared young WM patients to their older counterparts and found that young patients have lower overall survival and higher death attributable to WM. The treatment strategies for WM have not improved the outcome of young patients, and the impact of Bruton tyrosine kinase inhibitors on this patient population is still unknown.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nadine Abdallah, Angela Dispenzieri, Eli Muchtar, Francis K. K. Buadi, Prashant Kapoor, Martha Q. Q. Lacy, Yi L. L. Hwa, Amie Fonder, Miriam A. A. Hobbs, Suzanne R. R. Hayman, Nelson Leung, David Dingli, Ronald S. S. Go, Yi Lin, Wilson I. I. Gonsalves, Moritz Binder, Taxiarchis Kourelis, Rahma Warsame, Robert A. A. Kyle, S. Vincent Rajkumar, Morie A. A. Gertz, Shaji K. K. Kumar
Summary: After long-term follow-up, there is no clear evidence to support the benefit of doxycycline in the post-transplant setting.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2023)
Article
Oncology
Bharat Nandakumar, Francis Baffour, Nadine H. H. Abdallah, Shaji K. K. Kumar, Angela Dispenzieri, Francis K. K. Buadi, David Dingli, Martha Q. Q. Lacy, Suzanne R. R. Hayman, Prashant Kapoor, Nelson Leung, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Eli Muchtar, Rahma Warsame, Taxiarchis V. V. Kourelis, Ronald S. S. Go, Robert A. A. Kyle, Morie A. A. Gertz, S. Vincent Rajkumar, Jason Klug, Panagiotis Korfiatis, Wilson I. I. Gonsalves
Summary: Using a deep learning-based segmentation approach, sarcopenia can be accurately detected and measured in clinical computed tomography (CT) images of patients with newly diagnosed multiple myeloma (NDMM). Sarcopenia significantly affects overall survival in NDMM patients and is an independent adverse prognostic factor.
Article
Urology & Nephrology
Naba Farooqui, Mark Zaidi, Lisa Vaughan, Trevor D. McKee, Eram Ahsan, Kevin D. Pavelko, Jose C. Villasboas, Svetomir Markovic, Timucin Taner, Nelson Leung, Haidong Dong, Mariam P. Alexander, Sandra M. Herrmann
Summary: This study found that immune checkpoint inhibitors (ICIs) therapy may lead to acute kidney injury (AKI) and there are no biomarkers currently available to distinguish AKI caused by ICIs from other causes. The urine levels of cytokines such as TNF-a, IL-2, and IL-10 were significantly higher in AKI-ICI patients. Therefore, these T-cell responses and their respective cytokines may be helpful in differentiating AKI-ICI from AKI-other.
KIDNEY INTERNATIONAL REPORTS
(2023)
Letter
Hematology
Nate Gipe, Nelson Leung, Terra Lasho, Abhishek Mangaonkar, Hassan Alkhateeb, Aref Al-Kali, Naseema Gangat, William Hogan, Kristen McCullough, Ayalew Tefferi, Mariam Priya Alexander, Mrinal M. Patnaik
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Nelson Leung, S. Vincent Rajkumar
Summary: Light chain cast nephropathy (LCCN) is a significant cause of acute kidney injury (AKI) in patients with multiple myeloma (MM) and is now considered as a defining event of myeloma. While long-term prognosis has improved, short-term mortality remains higher in patients with LCCN if renal failure is not reversed. Rapid reduction of involved serum free light chain is critical for renal function recovery. Treatment algorithm for MM patients with biopsy-proven LCCN or ruling out other causes of AKI is provided based on randomized trial data whenever available. Clinical trial enrollment is recommended prior to following the treatment algorithm.
BLOOD CANCER JOURNAL
(2023)
Article
Oncology
Alexander J. Ryu, Shaji Kumar, Angela Dispenzieri, Robert A. Kyle, S. Vincent Rajkumar, Thomas C. Kingsley
Summary: This study used machine learning and electronic health record data to identify potential drug candidates for modifying the progression risk of MGUS. Various medications were found to be significantly associated with the risk of MGUS progression, which could inform future prospective studies.
BLOOD CANCER JOURNAL
(2023)
Article
Oncology
Velia Penza, Justin W. Maroun, Rebecca A. Nace, Autumn J. Schulze, Stephen J. Russell
Summary: An improved version of Mengovirus has been developed as a potential treatment for cancer, showing reduced side effects on the nervous system and heart muscle. By modifying the virus's genes, it can stably retain its therapeutic effects and target specific areas without causing harm to the host.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Editorial Material
Urology & Nephrology
Sheron Latcha, Nelson Leung
Review
Immunology
Hans-Joachim Anders, A. Richard Kitching, Nelson Leung, Paola Romagnani
Summary: 'Glomerulonephritis' (GN) refers to a group of immune-mediated disorders characterized by inflammation of the kidney's filtration units. Current classification is based on histopathological lesion patterns, but these patterns do not align well with the diverse pathological mechanisms and do not guide optimal therapy. Instead, a proposed immunopathogenesis-based classification groups GN disorders into five categories, allowing for more targeted and effective treatments.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Jason N. Barreto, Erin F. Barreto, Kristin C. Mara, Andrew D. Rule, John C. Lieske, Callen D. Giesen, Carrie A. Thompson, Nelson Leung, Thomas E. Witzig, Kianoush B. Kashani