Article
Pharmacology & Pharmacy
Zhiyu Zhang, Yingxin Sun, Su-Ning Chen
Summary: This study presented two cases of IHES that were refractory to corticosteroids and showed that Omalizumab may be a seminal therapeutic strategy for these patients, whether as long-term management of AEC or as an urgent intervention to address severe symptoms caused by eosinophilia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Critical Care Medicine
Antoine Gaillet, Pierre Bay, Edwige Peju, Hafid Ait-Oufella, Elie Azoulay, Nacime Benchabane, Charles Cerf, Yves Cohen, Nicolas de Prost, Stanislas Faguer, Guillaume Geri, Steven Grange, Jean-Emmanuel Kahn, Louis Kreitmann, Romaric Larcher, Guillaume Lefevre, Asma Mabrouki, Armand Mekonsto Dessap, Kewin Panel, Frederic Pene, Marc Pineton de Chambrun, Jean-Pierre Quenot, Yacine Tandjaoui-Lambiotte, Jean-Francois Timsit, Antoine Vieillard-Baron, Auguste Dargent, Antoine Herault, Matthieu Groh
Summary: This study retrospectively investigated the epidemiology and clinical manifestations of eosinophilia in the ICU among adult patients. The results showed that eosinophilia occurred in 0.9% of all ICU hospitalizations. Patients were divided into two groups based on the timing of eosinophilia, and different etiological workups and management approaches were required for each group.
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Chen E. Rosenberg, Paneez Khoury
Summary: The diagnosis of eosinophilia with pulmonary involvement requires a comprehensive evaluation of clinical, laboratory, and radiological features, and a systematic approach is essential. Treatment strategies should be tailored based on the underlying cause and urgency, with consideration of biologic therapies when appropriate.
Article
Allergy
Michelle A. Makiya, Paneez Khoury, Fei Li Kuang, Alexis Dominique Mata, Sana Mahmood, Abbie Bowman, David Espinoza, Nicholas Kovacs, Thomas Brown, Nicole Holland, Lauren Wetzler, JeanAnne M. Ware, Anne-Marie Dyer, Praveen Akuthota, Bruce S. Bochner, Vernon M. Chinchilli, Gerald J. Gleich, Carol Langford, Peter A. Merkel, Ulrich Specks, Peter F. Weller, Michael E. Wechsler, Calman Prussin, Michael P. Fay, Amy D. Klion
Summary: This study aimed to compare the reliability of measuring eosinophil granule proteins in urine and plasma, as well as other related proteins, in patients with eosinophil-associated diseases treated with different therapies. The measurement of urine eosinophil-derived neurotoxin (EDN) concentration might provide a potential biomarker of disease activity in patients with hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA).
Review
Clinical Neurology
Kathrin Miethe, Elene Iordanishvili, Pardes Habib, Jens Panse, Stefan Kraemer, Martin Wiesmann, Joerg B. Schulz, Omid Nikoubashman, Arno Reich, Joao Pinho
Summary: This study reported a case of HES patient and described the imaging patterns of cerebral ischemia in patients with HES through a systematic review. The results showed that the most common imaging pattern in HES patients is border zone distribution of cerebral ischemia without hemodynamic compromise.
NEUROLOGICAL SCIENCES
(2022)
Article
Pediatrics
Pinar Gur Cetinkaya, Elif Soyak Aytekin, Saliha Esenboga, Deniz Cagdas, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer
Summary: This study aimed to reveal the underlying causes of childhood eosinophilia and create a diagnostic algorithm. The most common causes of eosinophilia in children were allergic diseases and primary immunodeficiency. The duration of eosinophilia was correlated with the severity of the condition. Based on these findings, a diagnostic algorithm for childhood eosinophilia was presented.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pathology
Sebastian Fernandez-Pol, Bruce Petersen, Jo-Ellen Murphy, Jean S. Oak, Erica B. K. Wang, Kerri E. Rieger, Youn H. Kim, Michael S. Khodadoust, Carlos J. Suarez
Summary: LV-HES is a rare condition characterized by eosinophilia caused by eosinophilopoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is still unclear, but cases with pathogenic STAT3 mutations have been reported, supporting the model that activation of STAT3 signaling through STAT3 SH2 domain mutations is a recurring event in LV-HES.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Hematology
Grzegorz Helbig, Amy D. Klion
Summary: The article discusses the classification, diagnosis, and treatment of hypereosinophilic syndromes, emphasizing the importance of hematologic pathology and gene rearrangements in understanding these rare disorders.
Review
Medicine, General & Internal
Tomoki Origuchi, Tomohisa Uchida, Tatsuki Sakaguchi, Haruna Matsuo, Toru Michitsuji, Masataka Umeda, Toshimasa Shimizu, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Masahiro Ichinose, Koji Ando, Ichiro Horie, Nobuhiro Nakao, Junji Irie, Atsushi Kawakami
Summary: We report a case of a 78-year-old Japanese man with IgG4-related sialoadenitis complicated with marked eosinophilia. The patient showed a significant increase in peripheral eosinophil count after total incision of the submandibular gland and responded well to corticosteroid therapy. Previous cases of IgG4-related disease with severe eosinophilia were also reviewed.
Article
Dermatology
Lucia T. Fernandez, Jorge Ocampo-Candiani, Anabella Watts-Santos, Maria D. Guerrero-Putz, Sandra Nora Gonzalez-Diaz, Maria Del Carmen Zarate-Hernandez, Olga G. Cantu-Rodriguez, Maira E. Herz-Ruelas
Summary: Episodic hypereosinophilia and angioedema syndrome, known as Gleich syndrome, is a rare condition characterized by recurrent episodes of eosinophilia, angioedema, urticaria, fever and weight gain that resolve spontaneously. This article reports a case of a 42-year-old male with a 28-year history of recurrent erythematous wheals and plaques and persistent hypereosinophilia. Diagnosis was based on clinical and laboratory findings.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Dermatology
Jacqueline Zayas, Margot S. Peters, Joseph H. Butterfield, Thanai Pongdee, Olayemi Sokumbi
Summary: This retrospective study reviewed the clinical and histopathological features of cutaneous HES in adult patients with HES. The most common clinical morphologies were urticarial and eczematous, and the most frequent histopathological finding was a spongiotic pattern with abundant inflammation. Other organ systems were involved in the majority of cHES patients, with pulmonary involvement being the most common.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Qian Zhang, Daoyuan Si, Zhongfan Zhang, Wenqi Zhang
Summary: Loeffler endocarditis is a rare heart disease often associated with hypereosinophilic syndrome and intracardiac thrombus formation. Early use of corticosteroids and anticoagulation therapy may be beneficial, but the prognosis of this condition is typically poor with a relatively high mortality rate.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medicine, General & Internal
Noeul Kang, Ki Hong Choi, Sung Mok Kim, Duk-Kyung Kim, Kiick Sung, Dong-Chull Choi
Summary: Idiopathic hypereosinophilic syndrome (iHES) is a rare systemic disease characterized by persistent peripheral eosinophilia for more than 6 months, with organ damage and no primary cause for the eosinophilia. Coronary artery aneurysm (CAA) is a rare but life-threatening complication. We report a case of CAA with thrombosis in a patient with well-controlled iHES for several years. Close surveillance and monitoring for complications are crucial even with modest disease control.
YONSEI MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Mihaela Simona Popoviciu, Lorena Paduraru, Raluca Marinela Nutas, Alexandra Maria Ujoc, Galal Yahya, Kamel Metwally, Simona Cavalu
Summary: This narrative review focuses on secondary diabetes mellitus, exploring the main endocrinopathies and their impact on beta cell function and insulin resistance. The study highlights the importance of understanding the complex molecular mechanisms underlying secondary diabetes and metabolic syndrome to prevent disease development and complications, especially in terms of reducing cardiovascular risk in affected patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Peter Valent, Amy D. Klion, Florence Roufosse, Dagmar Simon, Georgia Metzgeroth, Kristin M. Leiferman, Juliana Schwaab, Joseph H. Butterfield, Wolfgang R. Sperr, Karl Sotlar, Peter Vandenberghe, Gregor Hoermann, Torsten Haferlach, Richard Moriggl, Tracy George, Cem Akin, Bruce S. Bochner, Jason Gotlib, Andreas Reiter, Hans-Peter Horny, Michel Arock, Hans-Uwe Simon, Gerald J. Gleich
Summary: Eosinophilia and eosinophil activation are common in various diseases. They can lead to hypereosinophilia and hypereosinophilic syndrome, which can cause organ damage. The classification and criteria for these conditions have been widely accepted and regarded as standard since 2012. However, new developments in the field have created a need to update these criteria. A recent working conference on eosinophil disorders discussed new markers and concepts, aiming to improve the diagnosis and management of patients with hypereosinophilia and hypereosinophilic syndrome.