Psychometric assessment of female overactive bladder syndrome and antimuscarinics-related effects

Objectives: To investigate the characteristics of psychological distress (PD), personality traits, and family support in women with overactive bladder syndrome (DAB), and the effects of antimuscarinic treatment. Study design: Women with and without DAB (age- and body mass index [BMI]-matched control group) were prospectively enrolled; they recorded bladder diaries, underwent urodynamic studies, and completed PD, personality traits, and filled family support questionnaires before and after antimuscarinic treatment. DAB women underwent treatment with tolterodine or solifenacin for 12 weeks. The control group completed questionnaires. Main outcome measures: The differences in PD, personality traits, and family support scores between both groups, and the changes after antimuscarinic treatment in OAB women. Results: Eighty-five women with OAB (tolterodine, n = 42; solifenacin, n =43) and 65 without DAB completed the studies. Linear regression analysis with age and BMI adjustment revealed: coefficients of DAB were significant (all P < 0.05) for somatic complaints (mean: 0.87 vs. 0.63, coefficient = 0.21), obsessive-compulsive symptoms (0.69 vs. 0.44, coefficient = 0.25), anxiety symptoms (0.42 vs. 0.27, coefficient = 0.14), General Symptom Index (GSI, 0.48 vs. 0.33, coefficient = 0.14), neuroticism (9.23 vs. 5.17, coefficient = 3.73), and extroversion-introversion (13.64 vs. 15.25, coefficient = -1.73). Anxiety symptoms (0.42 vs. 0.36) and GSI (0.48 vs. 0.39) improved after antimuscarinics (all P < 0.05). High Overactive Bladder Symptom Score questionnaire score (coefficient = -0.39), low hostility score (coefficient = 2.11), and. high additional symptoms score (coefficient = -1.46) were associated with good therapeutic effect (all P < 0.05). Conclusions: DAB women experience more PD, neuroticism, and introversion than asymptomatic women, and antimuscarinics could improve PD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.