期刊
MATURITAS
卷 74, 期 2, 页码 130-136出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2012.11.005
关键词
Epigenetics; Aging; Age-related diseases; Mitochondrial DNA
资金
- European Union's Seventh Framework Programme (FP7) [259679]
Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks, such as DNA methylation and numerous histone modifications, are emerging as important factors of the overall variation in life expectancy. In fact, epigenetic marks, that are responsible of the establishment of specific expression programs and of genome stability, represent a drawbridge across genetic, environmental and stochastic factors. In this review we provide an overview on the current knowledge and the general features of the epigenetic modifications characterizing the aging process. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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