期刊
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
卷 48, 期 6, 页码 699-705出版社
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0233-2015
关键词
Carbapenem resistance; Acinetobacter; Nosocomial infection; Oxacillinases
资金
- Research Fund from the University of Region of Joinville [Fundo de Apoio a Pesquisa/Universidade da Regiao de Joinville (FAP/UNIVILLE)]
Introduction: Carbapenems are the therapy of choice for treating severe infections caused by the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. We aimed to assess the prevalence and antimicrobial susceptibility profiles of producers of distinct oxacillinases among nosocomial isolates of the A. calcoaceticus-A. baumannii complex in a 249-bed general hospital located in Joinville, Southern Brazil. Methods: Of the 139 A. baumannii clinical isolates with reduced susceptibility to carbapenems between 2010 and 2013, 118 isolates from varying anatomical sites and hospital sectors were selected for genotypic analysis. Five families of genes encoding oxacillinases, namely bla(OXA-23-like), bla(OXA-24-like), bla(OXA-51-like), bla(OXA-58-like), and bla(OXA-143-like), were investigated by multiplex polymerase chain reaction (PCR). Results: Most (87.3%) isolates simultaneously carried the bla(OXA-23-like) and bla(OXA-51-like) genes, whereas three (2.5%) isolates harbored only bla(OXA-51-like) ones. The circulation of carbapenem-resistant isolates increased during the study period: from none in 2010, to 22 in 2011, 64 in 2012, and 53 in 2013. Conclusions: Isolates carrying the bla(OXA-23-like) and bla(OXA-51-like) genes were widely distributed in the hospital investigated. Because of the worsening scenario, the implementation of preventive measures and effective barriers is needed.
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