期刊
MATRIX BIOLOGY
卷 35, 期 -, 页码 14-17出版社
ELSEVIER
DOI: 10.1016/j.matbio.2014.01.014
关键词
Hyaluronan; O-GlcNAc transferase; Hyaluronan synthases; UDP-GlcNAc
资金
- [P01HL107147]
- [P01HL107153]
Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space. The cellular metabolism (synthesis and catabolism) of hyaluronan is dynamic. UDP-GlcNAc is also the substrate for O-GIcNAc transferase, which is central to the control of many cytosolic pathways. This Perspective outlines recent data for regulation of hyaluronan synthesis and catabolism that support a model that hyaluronan metabolism can be a rheostat for controlling an acceptable normal range of cytosolic UDPGIcNAc concentrations in order to maintain normal cell functions. (C) 2014 Elsevier B.V. All rights reserved.
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