Article
Biotechnology & Applied Microbiology
Jifeng Zeng, Yu Wang, Lixia Fan, Nuo Yang, Jiwen Pan, Yu Han, Xin Wang, Qian Li, Guiying Guo, Jiping Zheng, Weixin Zeng
Summary: This study aimed to investigate the molecular epidemiology, genotypes, and phenotypes of Streptococcus associated with bovine subclinical mastitis in Hainan, China. Results showed that environmental S. uberis plays a significant role in causing subclinical mastitis in Hainan, with distinct MLST, virulence, and antibiotic resistance characteristics.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Nives Maria Rosa, Ilaria Dupre, Elisa Azara, Carla Maria Longheu, Sebastiana Tola
Summary: Intramammary infections caused by Streptococcus uberis are a major concern for dairy sheep farms. This study analyzed 124 S. uberis isolates from sheep milk in Sardinia, Italy, revealing a high diversity among isolates and a high level of antimicrobial resistance, especially towards aminoglycosides. Multi-drug resistance was observed in some isolates, indicating the importance of continued monitoring and understanding of antimicrobial resistance in S. uberis strains.
Article
Agriculture, Dairy & Animal Science
Petr Slama, Terezie Zavadilova, Ales Pavlik, Pavel Horky, Sylvie Skalickova, Jiri Skladanka, Shubhadeep Roychoudhury, Simona Baldovska, Adriana Kolesarova, Roman Konecny, Vladimir Tancin, Monika Zouharova
Summary: Bovine mastitis is a significant issue for dairy farmers with antibiotic treatment needing to be minimized due to resistance. Streptococcus uberis is a common pathogen, with research indicating that gamma delta T cells may play a key role in resolving inflammation in mammary glands.
Article
Veterinary Sciences
Tingrui Zhang, Guoyi Niu, Sukolrat Boonyayatra, Duangporn Pichpol
Summary: The study found that S. uberis showed resistance to tetracycline and ceftiofur, with resistance levels increasing from 2010 to 2017. The most common antimicrobial resistance gene in S. uberis was tetM, with a significant increase in detection rates during the study period.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Valentina Monistero, Antonio Barberio, Paola Cremonesi, Bianca Castiglioni, Stefano Morandi, Desiree C. K. Lassen, Laerke B. Astrup, Clara Locatelli, Renata Piccinini, M. Filippa Addis, Valerio Bronzo, Paolo Moroni
Summary: The study revealed that Strep. uberis is an environmental pathogen responsible for mastitis in dairy cows in Italy, showing resistance to multiple antimicrobials with a low prevalence of beta-lactam resistance. The genotypic variability of the isolates was investigated using multiplex PCR and RAPD-PCR typing, along with phenotypic antimicrobial resistance assessment. The highest resistance rate was observed for lincomycin, with most isolates showing resistance to at least one drug tested.
Article
Infectious Diseases
Monika Zouharova, Katerina Nedbalcova, Katarina Matiaskova, Petr Slama, Jan Matiasovic
Summary: In this study, the antimicrobial susceptibility of Streptococcus uberis isolates from Czech dairy farms was assessed. The isolates showed high levels of resistance to tetracycline, streptomycin, and clindamycin, but were susceptible to beta-lactam antibiotics, particularly penicillin.
Article
Immunology
Riguo Lan, Zhixin Wan, Yuanyuan Xu, Zhenglei Wang, Shaodong Fu, Yuanyuan Zhou, Xinguang Lin, Xiangan Han, Zhenhua Luo, Jinfeng Miao, Yulong Yin
Summary: Streptococcus uberis is an important pathogen causing mastitis, and metabolic reprogramming during host immune responses is associated with infection-driven inflammation. The use of taurine can restore metabolic homeostasis and alleviate inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anna Dobrut, Dagmara Wojcik-Grzybek, Agata Mlodzinska, Dorota Pietras-Ozga, Katarzyna Michalak, Aleksander Tabacki, Urszula Mroczkowska, Monika Brzychczy-Wloch
Summary: This study aimed to detect immunoreactive proteins related to bovine mastitis through in silico and in vitro methods. Thirteen proteins were identified, which showed immunoreactivity to antibodies present in serum from cows with diagnosed mastitis. These proteins have the potential to be used as targets in rapid immunodiagnostic assays for bovine mastitis, but further research is needed due to the limited sample size.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Virginia E. Sherwin, Martin J. Green, James A. Leigh, Sharon A. Egan
Summary: Streptococcus uberis is a major causative agent of bovine mastitis worldwide. The prevalence of S. uberis in feces and factors affecting gastrointestinal carriage were investigated in two longitudinal studies. Seasonality and management conditions were found to significantly influence the detection of S. uberis.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Veterinary Sciences
Virginia E. Sherwin, Sharon A. Egan, Martin J. Green, James A. Leigh
Summary: This study demonstrates the importance of bedding type and management on the environmental survival of S. uberis. Bacteria can survive and replicate on bedding materials such as straw and sand for at least 35 days, but not beyond 7 days on sawdust. The addition of feces and urine on used bedding materials promotes the replication of S. uberis.
VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Atsushi Watanabe, Kazuhiro Kawai, Eiji Hata, Shinya Goto, Yasunori Shinozuka, Tomomi Kurumisawa, Yoshikazu Koyama, Yukio Chikayama, Yoshio Kiku, Yuya Nagasawa, Tomohito Hayashi
Summary: In this study, the variability of bovine clinical mastitis isolates of Streptococcus uberis in Japan was investigated using multilocus sequence typing. Results show that S. uberis is a diverse mastitis-causing pathogen, and the integrity of the vru gene upstream region is not necessarily conclusive for the occurrence of bovine clinical mastitis.
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2021)
Article
Veterinary Sciences
Zhixin Wan, Shaodong Fu, Zhenglei Wang, Yuanyuan Xu, Yuanyuan Zhou, Xinguang Lin, Riguo Lan, Xiangan Han, Zhenhua Luo, Jinfeng Miao
Summary: Foamy macrophages with lipid droplets play a role in the immune response to Streptococcus uberis-induced mastitis. The fatty acid synthesis pathway is enhanced during infection, leading to increased levels of lipid droplets and an intensified inflammatory response. This process is mediated by FABP4, a subtype of the fatty acid-binding protein family, and gene silencing of FABP4 decreases lipid droplet deposition and reduces inflammatory cytokine expression.
VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Larissa Martins, Juliano L. Goncalves, Renata F. Leite, Tiago Tomazi, Vera L. M. Rall, Marcos Santos
Summary: This study aimed to evaluate the association between antimicrobial use and antimicrobial resistance in relation to Streptococcus uberis causing clinical mastitis in dairy herds. The findings showed high resistance of Strep. uberis isolates to macrolides, tetracycline, and penicillin G, while lower resistance was observed for ceftiofur and enrofloxacin.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Immunology
Sohrab Khan, Jingyue Yang, Eduardo R. Cobo, Yue Wang, Maolin Xu, Tian Wang, Yuxiang Shi, Gang Liu, Bo Han
Summary: This study reveals that autophagy is induced during Uberis infection in cows, and IL-6, TNF-α, and IFN-γ play important roles in the regulation of autophagy and autophagy flux formation.
MICROBIAL PATHOGENESIS
(2023)
Article
Microbiology
Linda Fenske, Irene Noll, Jochen Blom, Christa Ewers, Torsten Semmler, Ahmad Fawzy, Tobias Eisenberg
Summary: Bovine mastitis caused by Streptococcus uberis is a common problem in the dairy industry, but the severity of clinical symptoms can vary greatly. This study conducted a comparative genomic analysis of S. uberis isolates from different infection courses, revealing unknown factors responsible for the severity and highlighting the importance of further research on the pathogenicity of S. uberis.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
L. Mamone, D. D. Ferreyra, L. Gandara, G. Di Venosa, P. Vallecorsa, D. Saenz, Gustavo Calvo, A. Batlle, F. Buzzola, E. N. Durantini, A. Casas
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2016)
Article
Oncology
Lautaro Gandara, Leandro Mamone, Cristian Dotto, Fernanda Buzzola, Adriana Casas
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2016)
Article
Engineering, Biomedical
Lautaro Gandara, Leandro Mamone, Gabriela Cervini Bohm, Fernanda Buzzola, Adriana Casas
LASERS IN MEDICAL SCIENCE
(2017)
Article
Immunology
Carlos M. Suligoy, Santiago M. Lattar, Mariangeles Noto Llana, Cintia D. Gonzalez, Lucia P. Alvarez, D. Ashley Robinson, Marisa I. Gomez, Fernanda R. Buzzola, Daniel O. Sordelli
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Immunology
Santiago M. Lattar, Maringeles Noto Llana, Philippe Denoel, Sophie Germain, Fernanda R. Buzzola, Jean C. Lee, Daniel O. Sordelli
INFECTION AND IMMUNITY
(2014)
Article
Biochemistry & Molecular Biology
L. Mamone, G. Di Venosa, L. Gandara, D. Saenz, P. Vallecorsa, S. Schickinger, M. V. Rossetti, A. Batlle, F. Buzzola, A. Casas
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Tom Grunert, Beatrix Stessl, Franz Wolf, Daniel O. Sordelli, Fernanda R. Buzzola, Monika Ehling-Schulz
SCIENTIFIC REPORTS
(2018)
Article
Plant Sciences
Ana Paula Perez, Noelia Perez, Carlos Mauricio Suligoy Lozano, Maria Julia Altube, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Fernanda Buzzola, Maria Jose Morilla, Eder Lilia Romero
Article
Multidisciplinary Sciences
Helene Marbach, Katharina Mayer, Claus Vogl, Jean Y. H. Lee, Ian R. Monk, Daniel O. Sordelli, Fernanda R. Buzzola, Monika Ehling-Schulz, Tom Grunert
SCIENTIFIC REPORTS
(2019)
Article
Pharmacology & Pharmacy
Gabriela Cervini Bohm, Lautaro Gandara, Gabriela Di Venosa, Leandro Mamone, Fernanda Buzzola, Adriana Casas
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Veronica Volpe, Monica N. Giacomodonato, Daniel O. Sordelli, Matias Insausti, Fernanda R. Buzzola, Marcos Grunhut
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Carlos M. Suligoy, Rocio E. Diaz, Ana-Katharina Gehrke, Natalie Ring, Gonzalo Yebra, Joana Alves, Marisa I. Gomez, Sindy Wendler, J. Ross Fitzgerald, Lorena Tuchscherr, Bettina Loeffler, Daniel O. Sordelli, Mariangeles Noto Llana, Fernanda R. Buzzola
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Cristian Dotto, Andrea Lombarte Serrat, Martin Ledesma, Carlos Vay, Monika Ehling-Schulz, Daniel O. Sordelli, Tom Grunert, Fernanda Buzzola
Summary: The study demonstrated that salicylic acid impairs biofilm dispersal of Staphylococcus aureus by interfering with agr expression, leading to reduced production of protease and surfactant molecules, as well as negative effects on bacterial cell autolysis. It also revealed the lack of extracellular DNA in the biofilm matrix. Additionally, in silico docking and simulation suggested a potential interaction between AgrA and SAL, resulting in reduced activity of the agr system.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Maria Emilia Caceres, Martin Manuel Ledesma, Andrea Lombarte Serrat, Carlos Vay, Daniel Oscar Sordelli, Onica Nancy Giacomodonato, Fernanda Roxana Buzzola
Summary: The study evaluated the effect of different growing culture conditions on the biofilm formation of clinical mastitis pathogens, with MALDI-TOF-MS proving to be an excellent tool for discriminating between different biofilm formation levels. Some strains showed increased biofilm formation in milk. Free iron medium and milk whey inhibited biofilm formation in most strains.
CURRENT RESEARCH IN MICROBIAL SCIENCES
(2021)