期刊
MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
卷 30, 期 2, 页码 115-130出版社
OXFORD UNIV PRESS
DOI: 10.1093/imammb/dqr030
关键词
blebbing; cell cortex; cell mechanics; intracellular fluid flow; immersed boundary method; porous media
资金
- National Institutes of Health Glue Grant 'Cell Migration Consortium' [NIGMS U54 GM64346]
- National Science Foundation-Division of Mathematical Sciences [0540779]
- University of California, Office of the President [09-LR-03-116724-GUYR]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [0540779] Funding Source: National Science Foundation
Blebbing occurs when the cytoskeleton detaches from the cell membrane, resulting in the pressure-driven flow of cytosol towards the area of detachment and the local expansion of the cell membrane. Recent interest has focused on cells that use blebbing for migrating through 3D fibrous matrices. In particular, metastatic cancer cells have been shown to use blebs for motility. A dynamic computational model of the cell is presented that includes mechanics of and the interactions between the intracellular fluid, the actin cortex and the cell membrane. The computational model is used to explore the relative roles in bleb formation time of cytoplasmic viscosity and drag between the cortex and the cytosol. A regime of values for the drag coefficient and cytoplasmic viscosity values that match bleb formation timescales is presented. The model results are then used to predict the Darcy permeability and the volume fraction of the cortex.
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