期刊
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
卷 16, 期 2, 页码 79-91出版社
SPRINGER
DOI: 10.1007/s11154-015-9316-1
关键词
Bone remodeling; Osteoclasts; Osteoblasts; Osteocytes; Bone formation; Bone resorption; Wnt signaling; Osteocalcin; FGF23; Phosphate homeostasis; Calcium homeostasis; Calcium sensing receptor; RANK ligand; Leptin; Sclerostin; PTH; TGF-beta; 1,25 dihydroxy vitamin D
Adding to its well-known roles in locomotion and calcium balance, the skeleton has recently been appreciated as a true endocrine organ. Bone remodeling, a highly dynamic process, requires synchronized activities and crosstalk between bone cells. Discovery and characterization of the Wnt/beta catenin pathway in bone formation, FGF23 regulation of phosphate homeostasis and osteocalcin in energy and glucose homeostasis have reframed our view of the skeleton from simply a target tissue of the endocrine system to an endocrine tissue itself. This comprehensive review provides an overview of these complex pathways, their application to human bone disorders and implications for developing diagnostic and therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据