Article
Biology
James Sneyd, Elias Vera-Siguenza, John Rugis, Nathan Pages, David Yule
Summary: Saliva is secreted from the acinar cells of the salivary glands in a mechanism similar to other water-transporting epithelial cells. Over the past 20 years, a quantitative model of saliva secretion has been continuously developed and modified, with a focus on the control by intracellular calcium dynamics. Recent advancements in understanding the underlying mechanisms have led to important modifications to the traditional view of saliva secretion.
BULLETIN OF MATHEMATICAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Roberto Ornelas-Guevara, Diana Gil, Valerie Voorsluijs, Genevieve Dupont
Summary: Inositol 1,4,5-trisphosphate (IP3) plays a key role in calcium signaling. Previous studies overestimated the diffusion coefficient of IP3 in vivo, but new computational analysis shows that the effective diffusion coefficient is close to 100 μm(2)s(-1), significantly lower than previous estimations. This moderate reduction can be explained by the buffering effect of non-fully bound inactive IP3 receptors.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Hong Ki Min, Se Hee Kim, Kyung-Ann Lee, Joon-Hyung Jo, Young So, Hyun Woo Chung, Sang-Heon Lee, Hae-Rim Kim
Summary: This study compared the findings of salivary gland ultrasonography (SGUS) and salivary gland scintigraphy (SGS) in patients with primary SS. The study found that patients with a higher SGUS score had lower salivary gland function, and there was a significant correlation between SGUS score and SGS results. These findings suggest a possible predictive role of SGUS in diagnosing salivary gland dysfunction.
Article
Biology
Takahiro Takano, Amanda M. Wahl, Kai-Ting Huang, Takanori Narita, John Rugis, James Sneyd, David Yule
Summary: In this study, researchers found that the Ca2+ signals in salivary secretion process in live mice initiate in the apical endoplasmic reticulum, forming highly localized trains of transient that fail to fully propagate, leading to large apical-basal gradients following optimal stimuli for secretion. A new mathematical model incorporating these findings will help to understand how salivary secretion can be optimally stimulated by apical Ca2+ signals.
Review
Medicine, General & Internal
Rui Liao, Hai-Tao Yang, Heng Li, Li-Xiong Liu, Kai Li, Jing-Jing Li, Jie Liang, Xiao-Ping Hong, Yu-Lan Chen, Dong-Zhou Liu
Summary: Sjogren's syndrome is a chronic autoimmune disease with complicated clinical manifestations. Salivary gland biopsy plays a crucial role in diagnosis and risk assessment for the disease.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Martha S. van Ginkel, Tineke van der Sluis, Marian L. C. Bulthuis, Henk J. Buikema, Erlin A. Haacke, Suzanne Arends, Stine Harder, Fred K. L. Spijkervet, Hendrika Bootsma, Arjan Vissink, Frans G. M. Kroese, Bert van der Vegt
Summary: Objective digital image analysis (DIA) algorithm can be used to identify lymphoepithelial lesions (LELs) in salivary glands of primary Sjögren's syndrome (pSS) patients. The presence of intraepithelial B-lymphocytes can serve as a clear indicator of pSS and an objective alternative to LEL scoring.
Article
Biophysics
Victor Nicolai Friedhoff, Benjamin Lindner, Martin Falcke
Summary: This article investigates the randomness and properties of Ca2+ signaling in cells. The researchers found that the generation of Ca2+ spikes follows certain patterns and can be described as a process from one state to another. They proposed a theoretical model to explain the differences in spike behavior between different cell types and stimulating agonists, as well as the variability observed in experiments.
BIOPHYSICAL JOURNAL
(2023)
Review
Microbiology
Indu Muraleedharan Nair, Emma Condon, Barbara Doyle Prestwich, John James Mackrill
Summary: Oomycetes are pathogens that cause significant losses to agriculture, aquaculture, and forestry. This study explores the similarities and differences in the myo-inositol 1,4,5 trisphosphate signaling pathway between oomycetes and other eukaryotes.
Review
Immunology
Zhen Tan, Li Wang, Xiaomei Li
Summary: This paper summarizes recent studies on the salivary glands of pSS patients from the perspective of the immune microenvironment. It demonstrates that hypoxia, senescence, and chronic inflammation are the essential characteristics of the salivary gland immune microenvironment in pSS. Multiple signaling pathways are involved in its regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Akinsola Oyelakin, Erich Horeth, Eun-Ah Christine Song, Sangwon Min, Monika Che, Brandon Marzullo, Christopher J. Lessard, Astrid Rasmussen, Lida Radfar, R. Hal Scofield, David M. Lewis, Donald U. Stone, Kiely Grundahl, Scott S. De Rossi, Zoya Kurago, A. Darise Farris, Kathy L. Sivils, Satrajit Sinha, Jill M. Kramer, Rose-Anne Romano
Summary: Primary Sjogren's syndrome is a systemic autoimmune disease primarily affecting women, leading to loss of saliva and tears. Currently, there is no effective cure due to limited understanding of disease etiology and pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hongen Yin, Thomas J. F. Pranzatelli, Benjamin N. French, Nan Zhang, Blake M. Warner, John A. Chiorini
Summary: The study developed a novel method for quantifying fibrosis in the salivary gland and found a significant correlation between fibrosis and symptoms in SS patients. Fibroblasts may play a key role in expressing genes related to fibrosis in the gland.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Farzana Chowdhury, Anwar Tappuni, Michele Bombardieri
Summary: Primary Sjogren's syndrome is a chronic autoimmune disease affecting salivary and lachrymal glands, causing dry mouth and eyes symptoms. There is currently no disease-modifying drug approved for treatment, with therapies focused on symptom relief. Management of oral dryness remains a significant unmet clinical need for patients with pSS.
FRONTIERS IN MEDICINE
(2021)
Article
Anatomy & Morphology
Arthur R. Hand, Cailyn X. G. Abramson, Keith A. Dressler
Summary: Tlx1 is a crucial gene in the development of salivary glands in mice, specifically in the differentiation of submandibular and sublingual gland acinar cells and granular convoluted ducts. The exact mechanism of Tlx1 regulation in salivary gland development and differentiation remains unknown.
JOURNAL OF ANATOMY
(2023)
Article
Geriatrics & Gerontology
Mengna Wu, Boyue Huang, Ling Hu, Tao Zhang, Binyu Zhang, Xi Zhao, Ruijin Lu, Wei Xiong, Shengyao Zhang, Jing Li, Dilong Chen, Baoxue Yang, Guoli Li, Jianhua Ran
Summary: Long-term saliva secretion deterioration is observed in aging, leading to impaired swallowing and chewing abilities and reduced quality of life for the elderly. Ganoderma lucidum polysaccharide (GLP) has been found to effectively promote saliva secretion and reduce inflammation and apoptosis in the submandibular gland (SMG) during aging, making it a potential drug for maintaining healthy salivary gland function in the elderly.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Immunology
Loukas Chatzis, Andreas Goules, Vasilis Pezoulas, Chiara Baldini, Saviana Gandolfo, Fotini N. Skopouli, Themis P. Exarchos, Efstathia K. Kapsogeorgou, Valentina Donati, Paraskevi V. Voulgari, Clio P. Mavragani, Vasilis Gorgoulis, Salvatore De Vita, Dimitrios Fotiadis, Michalis Voulgarelis, Haralampos M. Moutsopoulos, Athanasios G. Tzioufas
Summary: The study aimed to explore the role of LMSG focus score (FS) in stratifying SS patients, with findings identifying FS, cryoglobulinemia, and salivary gland enlargement (SGE) as independent lymphoma-associated risk factors. Patients with FS >= 4 had a shorter time interval to lymphoma diagnosis and were more likely to develop B cell origin manifestations and lymphoma. These results suggest that FS evaluated at the time of SS diagnosis may serve as a predictive biomarker for early diagnosis of SS-associated lymphomas.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Huguette Croisier, Xiahui Tan, Jun Chen, James Sneyd, Michael J. Sanderson, Bindi S. Brook
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2015)
Article
Biology
Katie Sharp, Edmund Crampin, James Sneyd
JOURNAL OF THEORETICAL BIOLOGY
(2015)
Article
Neurosciences
Peter Bratby, James Sneyd, John Montgomery
Article
Neurosciences
Peter Bratby, James Sneyd, John Montgomery
Article
Neurosciences
Sebastian Boie, Jun Chen, Michael J. Sanderson, James Sneyd
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Biology
Sebastian Boie, Vivien Kirk, James Sneyd, Martin Wechselberger
JOURNAL OF THEORETICAL BIOLOGY
(2016)
Article
Biology
James Sneyd, Shawn Means, Di Zhu, John Rugis, Jong Hak Won, David I. Yule
JOURNAL OF THEORETICAL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
James Sneyd, Jung Min Han, Liwei Wang, Jun Chen, Xueshan Yang, Akihiko Tanimura, Michael J. Sanderson, Vivien Kirk, David I. Yule
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemical Research Methods
Jung Min Han, Akihiko Tanimura, Vivien Kirk, James Sneyd
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Physiology
Janos Almassy, Elias Siguenza, Marianna Skaliczki, Klara Matesz, James Sneyd, David I. Yule, Peter P. Nanasi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2018)
Article
Biology
Nathan Pages, Elias Vera-Sigueenza, John Rugis, Vivien Kirk, David I. Yule, James Sneyd
BULLETIN OF MATHEMATICAL BIOLOGY
(2019)
Article
Biology
Elias Vera-Siguenza, Marcelo A. Catalan, Gaspar Pena-Munzenmayer, James E. Melvin, James Sneyd
BULLETIN OF MATHEMATICAL BIOLOGY
(2018)
Proceedings Paper
Biophysics
Anna Qian, Shawn Means, Leo K. Cheng, James Sneyd, Peng Du
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2017)
Article
Biophysics
Pengxing Cao, Martin Falcke, James Sneyd
BIOPHYSICAL JOURNAL
(2017)
Article
Gastroenterology & Hepatology
Shelley Fong, John A. Chiorini, James Sneyd, Vinod Suresh
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2017)