Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Alaa Din Abdin, Wissam Aljundi, Khalil El Jawhari, Shady Suffo, Isabel Weinstein, Berthold Seitz
Summary: The study aimed to evaluate the morphological and functional outcomes of intravitreal brolucizumab treatment for refractory neovascular age-related macular degeneration (nAMD) in the first year. Results showed that brolucizumab could stabilize visual acuity and reduce the number of injections. It also improved anatomical outcomes by reducing subretinal fluid and pigment epithelial detachment. However, adverse events such as intraocular inflammation were observed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Tanishq S. Sharma, Shashikant M. Sharma
Summary: This case report presented a 59-year-old female patient with wet ARMD in the right eye, dry ARMD in the left eye, and pseudophakia in both eyes. The patient received intravitreal ranibizumab injections for the wet ARMD in the right eye, resulting in improvements in visual acuity and resolution of subretinal fluid.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Ophthalmology
Manuel Saenz-de-Viteri, Sergio Recalde, Patricia Fernandez-Robredo, Maria Isabel Lopez Galvez, Lluis Arias Barquet, Marta S. Figueroa, Jose Garcia-Arumi, Alfredo Garcia-Layana
Summary: Patients with subretinal fluid (SRF) at the end of the loading phase had better visual outcomes compared to those with intraretinal fluid (IRF). However, the persistence of SRF did not affect visual outcomes across the different treatment regimens. On the other hand, the presence of IRF was associated with poorer visual outcomes, especially in the fixed bimonthly (FBM) group.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Jorge Sanchez-Monroy, Vuong Nguyen, Martin Puzo, Pilar Calvo, Carolina Arruabarrena, Pietro Monaco, Michael Chilov, David Keegan, Daniel Barthelmes, Mark Gillies
Summary: This study aimed to assess the association between macular atrophy and macular neovascularization activity in patients with neovascular age-related macular degeneration using optical coherence tomography. The results showed that subretinal fluid has a protective effect against macular atrophy. Differentiating retinal fluid compartments and understanding their relationship with macular atrophy and fibrosis can guide the management of neovascular age-related macular degeneration.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Rubble Mangla, Pranjal Mishra, Harshita Nahata, Naresh K. Yadav, Jay Chhablani
Summary: This study investigates the factors leading to the development of bridge arch-shaped subretinal fluid (SRF) in wet age-related macular degeneration and evaluates its anatomical and functional outcomes. Results show that the development of bridge arch-shaped SRF is associated with a further reduction in visual acuity and is relatively rare. It is likely related to retinal pigment epithelium breach, tear, and nonaggressive treatment regimen.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Sam Razavi, Laurent Kodjikian, Audrey Giocanti-Auregan, Ingrid Dufour, Eric Souied
Summary: The TITAN study demonstrated that switching ranibizumab-refractory patients with nAMD to IVT-AFL may improve visual outcomes in some patients, particularly those who receive three initial monthly injections.
Article
Oncology
Pradeep Kumar Panigrahi
Summary: A 72-year-old male with wet neovascular age related macular degeneration in left eye presented with loss of vision for 1 year. After receiving intravitreal Brolucizumab, there was complete resolution of subretinal fluid and improvement in vision, which was maintained for 3 months with the macula remaining dry.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Multidisciplinary Sciences
Annekatrin Rickmann, Lina R. Paez, Maria della Volpe Waizel, Lukas Bisorca-Gassendorf, Andre Schulz, Anne-Cecile Vandebroek, Peter Szurman, Kai Januschowski
Summary: This study analyzed the outcomes of vitrectomy with subretinal rtPA injection with or without intravitreal Bevacizumab injection for submacular hemorrhage. The results showed that both methods effectively improved visual acuity and central macular thickness, while achieving successful displacement of hemorrhage.
Article
Medicine, General & Internal
Pasquale Viggiano, Maria Oliva Grassi, Giacomo Boscia, Mariagrazia Pignataro, Giovanni Petruzzella, Enrico Borrelli, Teresa Molfetta, Giovanni Alessio, Francesco Boscia
Summary: The study explores the morphofunctional fluctuations in eyes treated for neovascular AMD when switching from aflibercept or ranibizumab to brolucizumab. The results showed that brolucizumab treatment improved visual function in patients and resulted in choroidal vascular enlargement and resolution of subretinal and intraretinal fluid.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Alper Bilgic, Laurent Kodjikian, Shail Vasavada, Shyamal Jha, Samaresh Srivastava, Aditya Sudhalkar, Thibaud Mathis
Summary: The study found that brolucizumab demonstrated significant efficacy in managing CNV patients with RPE tears and subretinal fluid, showing substantial improvements in visual and anatomical outcomes without complications during one-year follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Zhuangling Lin, Lijun Zhou, Chuangxin Huang, Zijing Li, Tu Lu, Qifeng Cong, Jiandong Liang, Xiaojing Zhong, Lin Lu, Chenjin Jin
Summary: A 64-year-old female with acute painless vision loss in the left eye was diagnosed with neovascular age-related macular degeneration. Over the 20-year follow-up period, the patient experienced multiple complications, such as subretinal fluid, subretinal hemorrhage, pigmentary epithelium detachment, intraretinal fluid, subretinal scar formation, and macular atrophy. Various treatments, including PDT, intravitreal bevacizumab, and ranibizumab injections, were performed, but the patient still had poor visual acuity and significant macular damage at the last visit.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Ophthalmology
Justis P. Ehlers, Nikhil Patel, Peter K. Kaiser, Jeffrey S. Heier, David M. Brown, Xiangyi Meng, Jamie Reese, Leina Lunasco, Thuy K. Le, Ming Hu, Sunil K. Srivastava
Summary: This study evaluated the association between fluid volatility and EZ integrity and SHRM volume during anti-VEGF therapy in nAMD. The results suggest that high volatility is associated with increased SHRM volume and less improvement in EZ integrity.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Vuong Nguyen, Martin Puzo, Jorge Sanchez-Monroy, Pierre-Henry Gabrielle, Catherine C. Garcher, Florian Baudin, Benjamin Wolff, Laurent Castelnovo, Guillaume Michel, Louise O'Toole, Daniel Barthelmes, Mark C. Gillies
Summary: This study assessed the relationship between subretinal fluid (SRFL), intraretinal fluid, and visual outcomes of neovascular age-related degeneration, highlighting the importance of distinguishing between intraretinal fluid and SRFL in managing this condition. Eyes with SRFL alone showed similar outcomes after 1 year compared to eyes that were mainly inactive, emphasizing the significance of understanding the impact of different types of fluid on visual outcomes.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Jose Navarro-Partida, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, Jesus Gonzalez-Cortes, Sergio Hernandez-Da Mota, Jose Gerardo Garcia-Aguirre, Carlos David Azuara-Galindo, Carlos Rodrigo Castro-Castaneda, Juan Armendariz-Borunda, Arturo Santos
Summary: A study evaluated the safety and efficacy of using a triamcinolone-loaded liposome formulation as an adjuvant to intravitreal ranibizumab therapy in treatment-naive patients with neovascular age-related macular degeneration. The results showed a significant reduction in the average number of ranibizumab injections when using the liposome formulation, with optimal visual and anatomic outcomes.