Article
Chemistry, Medicinal
Juhee Park, Ga-Eun Lee, Hyung-Jung An, Cheol-Jung Lee, Eun Suh Cho, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Jin-Sung Choi, Dae Joon Kim, Jong-Soon Choi, Yong-Yeon Cho
Summary: Kaempferol targeting RSKs may be a strategy to reduce oxaliplatin-resistant colon cancer cells. The study provides evidence that molecular mechanisms for drug resistance in human cancer are crucial in overcoming this challenge.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Oncology
Margaret H. Sundel, Natalia Sampaio Moura, Kunrong Cheng, Oscar Chatain, Shien Hu, Cinthia B. Drachenberg, Guofeng Xie, Jean-Pierre Raufman
Summary: Studies have found that the expression of M1R and M3R differs in the progression of colon neoplasia. Activation of M1R selectively inhibits cell proliferation in colon cancer cells and enhances the anti-proliferative effects of conventional chemotherapeutic agents.
Article
Biochemistry & Molecular Biology
Ting-Ann Lin, Wei-Sheng Lin, Ya-Chun Chou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hisung Pan
Summary: The study demonstrates that OXY inhibits human colon cancer cell migration by regulating both EMT and miRNAs, suggesting its potential anti-metastatic properties in CRC.
Article
Medicine, Research & Experimental
Guoxiang Jiang, Ruihua Zhang, Xuan Yang, Wen Zhang, Yubin Hou
Summary: The research found that the expression level of miRNA-570 is low in colon cancer, and is associated with tumor size, extent of differentiation, lymph node metastasis, and tumor stage. The downregulation of miR-570 indicates poor prognosis in colon cancer patients, with independent clinical prognostic value.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Zhengxiong Chen, Xinyu Wang, Jing Luo, Bowen Zhang, Fei Shen, Binbin Li, Jing Yang
Summary: In this study, rod-like hydroxyapatite modified with two different amino acids was synthesized, showing that amino acids can reduce the aspect ratio and crystallinity of hydroxyapatite, while exhibiting better biocompatibility and inhibitory effects on osteosarcoma cells.
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Multidisciplinary Sciences
Micaela G. Fosdick, Shannon Loftus, Isabella Phillips, Zeb R. Zacharias, Jon C. D. Houtman
Summary: The study demonstrates that glycerol monolaurate (GML) not only has antimicrobial properties and can be used in treating various diseases, but also affects the physiological functions of immune cells. GML inhibits protein clustering and alters cellular membrane dynamics when affecting human B cells. There are similarities and differences in how B cells and T cells respond to GML.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Martina Karasova, Jirina Prochazkova, Zuzana Tylichova, Radek Fedr, Miroslav Ciganek, Miroslav Machala, Zdenek Dvorak, Barbora Vyhlidalova, Iveta Zuvalova, Jiri Ehrmann, Jan Bouchal, Zdenek Andrysik, Jan Vondracek
Summary: Aryl hydrocarbon receptor (AhR) plays diverse physiological roles in cellular processes such as proliferation, migration, and immune response control. Studies suggest that AhR may contribute to the regulation of energy balance and cellular metabolism, particularly fatty acid synthesis. In colon tumor cells, disruption of AhR activity may limit proliferation and affect endogenous fatty acid metabolism.
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Mengying Sun, Wenwen Liu, Yinglong Song, Yanfeng Tuo, Guangqing Mu, Fenglian Ma
Summary: The EPS produced by Lactobacillus plantarum-12 was found to significantly inhibit HT-29 cell proliferation and induce apoptosis through the mitochondrial pathway, by upregulating pro-apoptotic proteins and downregulating anti-apoptotic proteins.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biotechnology & Applied Microbiology
Shengxun Mao, Zhaohong Mo, Runxin Wu, Bin Lai, Zhiyong Zhou, Yi Song, Xi Ouyang, Xingen Zhu
Summary: DUXAP8 is upregulated in colon cancer and is associated with advanced stages and lymph node metastases. High expression of DUXAP8 is correlated with shorter overall survival in patients. Silencing of DUXAP8 inhibits cellular proliferation, migration, and invasion, while overexpression accelerates these processes.
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Anatomy & Morphology
Ayse Cakir Gundogdu, Rumeysa Ozyurt
Summary: Epithelial sodium channels (ENaCs) play important roles in cancer progression, including proliferation, migration, invasion, and apoptosis. Inhibition of ENaCs may have therapeutic potential in cancer treatment. Resveratrol, a natural polyphenol, activates AMP-activated protein kinase (AMPK) and reduces ENaC abundance in cell membrane. However, the effects of resveratrol on ENaCs in cancer cells are unknown. This study investigated the effects of resveratrol on ENaCs in human colon cancer cells and found that resveratrol activates AMPK, inhibits ENaCs, decreases cell viability, and increases apoptosis. These findings suggest that ENaC inhibition through AMPK activation may contribute to the anti-cancer effects of resveratrol.
Article
Cell Biology
Sumati Hasani, Lyndsay E. A. Young, Warren Van Nort, Moumita Banerjee, Dylan R. Rivas, Jinhwan Kim, Xiaopeng Xiong, Ramon C. Sun, Matthew S. Gentry, Hiromi Sesaki, Tianyan Gao
Summary: Loss of Drp1 activates compensative metabolic pathways, glucose uptake and glycogenesis, to promote cell survival in colon cancer.
CELL DEATH & DISEASE
(2023)
Article
Pharmacology & Pharmacy
Jian Gao, Zhigui Wu, Mingxia Zhao, Rui Zhang, Manru Li, Dongdong Sun, Haibo Cheng, Xianjia Qi, Yuxian Shen, Qiang Xu, Hongqi Chen, Dijun Chen, Yang Sun
Summary: This study reveals the role of SHP2 in innate immunosuppression in the tumor microenvironment. Inhibition of SHP2 can effectively arrest the malignant evolution of tumor cells and activate the interferon signaling pathway in infiltrated myeloid cells. The findings also suggest a potential role of macrophagic SHP2 in colon cancer immunotherapy, especially in patients with MSS phenotype.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Physical
Anuradha Jana, Mitun Das, Vamsi Krishna Balla
JOURNAL OF ALLOYS AND COMPOUNDS
(2020)
Article
Materials Science, Composites
Akrity Anand, Mitun Das, Biswanath Kundu, Vamsi Krishna Balla, Subhadip Bodhak, S. Gangadharan
Summary: The TiB-TiN in-situ reinforced Ti6Al4V alloy composite coatings displayed superior tribocorrosion resistance due to their high hardness and non-passivating nature, with corrosion playing a dominant role in affecting the wear of all materials.
JOURNAL OF COMPOSITE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Mitun Das, Orna Sharabani-Yosef, Noam Eliaz, Daniel Mandler
Summary: The study developed hybrid scaffolds with enhanced osteogenic and angiogenic performance by combining hydrogels with 3D-printed PLA scaffolds. Surface-modified PLA scaffolds integrated well with hydrogels and showed the lowest weight loss during 21 days of immersion.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Monideepa Mukherjee, Jaydeb Kundu, Vamsi Krishna Balla, Mitun Das, K. Sai Babu, G. V. Murali Krishna, Mahadev Shome
Summary: The study evaluated the feasibility of using water-atomized low-alloy steel powders in laser additive manufacturing, demonstrating the unique microstructures obtained and the significant improvement in mechanical properties after heat treatment. However, concerns such as porosity and loss of alloying elements were identified, indicating the need for further optimization of powder characteristics to fully exploit the potential of this additive manufacturing method.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Article
Biophysics
S. Thanka Rajan, Mitun Das, P. Sasi Kumar, A. Arockiarajan, B. Subramanian
Summary: This study investigates the effect of boron in Ti-Cu-Pd-Zr metallic glass matrix for biomedical implants fabricated by PLD. The results show that increasing boron content in TFMG leads to improved glass transition temperatures and enhances corrosion resistance, passivity, and biocompatibility. This combination of properties makes these TFMG systems potential candidates for biomedical implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Engineering, Biomedical
Anuradha Jana, Mitun Das, Vamsi Krishna Balla
Summary: The review discusses the degradation behavior of biodegradable Mg alloys, focusing on in vitro and in vivo corrosion, as well as preventive measures for biomedical applications. It emphasizes the need for a standard method of corrosion assessment to predict in vivo corrosion rates based on in vitro data.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Nanoscience & Nanotechnology
Souvik Sahoo, Anuja Joshi, Vamsi K. Balla, Mitun Das, Shibayan Roy
Summary: In this study, pre-alloyed Ti-6Al-4V powder was deposited on a CP-Titanium substrate using the LENS™ process to achieve optimal adhesion and densification. The resulting microstructure displayed columnar beta grains and thin lamellar (alpha+beta)-colonies, with additional interfaces created due to re-melting between layers. Variations in hardness and COF were observed along different surfaces and directions, indicating potential performance issues in the as-deposited parts.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Article
Materials Science, Multidisciplinary
David Svetlizky, Mitun Das, Baolong Zheng, Alexandra L. Vyatskikh, Susmita Bose, Amit Bandyopadhyay, Julie M. Schoenung, Enrique J. Lavernia, Noam Eliaz
Summary: Directed energy deposition (DED) is a branch of additive manufacturing (AM) processes that allows for site-specific deposition and repair, alloy design, and complex shape printing. This review critically examines recent advances in laser-material interactions, melt pool thermal behavior, and monitoring techniques, while also discussing critical processing variables, defect formation mechanisms, and high-end applications and challenges associated with DED processing.
Article
Materials Science, Multidisciplinary
Swarnima Singh, Krishna Kant Pandey, Vamsi Krishna Balla, Mitun Das, Anup Kumar Keshri
Summary: The study found that SMAT treatment can significantly reduce the corrosion rate of Ti-6Al-4V alloy and improve its wear resistance and cell adhesion properties. This effect is attributed to the formation of a TiO2 passive film due to nanocrystallization.
Article
Materials Science, Ceramics
Pallabi Roy, Poulomi Mukherjee, Anuradha Jana, Mitun Das, Sumana Ghosh
Summary: This study compared the performance changes of conventional TBC and glass-ceramic bond-coated TBC after high-temperature thermal cycling, and found that glass-ceramic bond-coated TBC has better thermal resistance and coating spallation protection capabilities.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
David Svetlizky, Baolong Zheng, Alexandra Vyatskikh, Mitun Das, Susmita Bose, Amit Bandyopadhyay, Julie M. Schoenung, Enrique J. Lavernia, Noam Eliaz
Summary: Directed energy deposition (DED) has become an important branch of additive manufacturing (AM) and is widely used in the design and fabrication of various materials. Successful DED operation requires a good understanding of critical phenomena such as laser-material interactions, alloy solidification, welding metallurgy, and microstructure-mechanical properties relations. This comprehensive review focuses on materials design via DED, including a survey of different compositions and highlights the challenges and opportunities in this area.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Correction
Materials Science, Multidisciplinary
Anuradha Jana, Sourav Dutta, Mangal Roy, U. Aravind, Mitun Das, Vamsi Krishna Balla
Article
Metallurgy & Metallurgical Engineering
Nimu Chand Reger, K. Bavya Devi, Vamsi Krishna Balla, Mitun Das
Summary: In this study, an attempt was made to develop in-situ grown ceramic layer on additively manufactured Zr metal by thermal oxidation. Detailed characterization and testing were performed to determine the properties of the ceramic layer and its impact on wear and corrosion resistance. The results showed that the thickness of the ceramic layer increased significantly at higher oxidation temperatures, and the samples oxidized at 600 degrees C for 6 h demonstrated the lowest wear rate. Formation of oxide phases on Zr also significantly increased the corrosion resistance in Hanks Balanced Salt solution.
TRANSACTIONS OF THE INDIAN INSTITUTE OF METALS
(2023)
Article
Chemistry, Physical
S. Thanka Rajan, Mitun Das, A. Arockiarajan
Summary: In this study, tantalum oxide thin films were deposited onto the surface of AZ31B alloy using the sputtering process, and their biocompatibility and corrosion resistance were evaluated. The results showed that the Ta-based thin films significantly enhanced the corrosion resistance of the magnesium alloy, exhibited good bioactivity, and had good hemocompatibility.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Anuradha Jana, Sourav Dutta, Mangal Roy, U. Aravind, Mitun Das, Vamsi Krishna Balla
Summary: The study found that hot rolling significantly affects the microstructure, hardness, and corrosion resistance of magnesium alloys, but has minimal impact on biocompatibility. Hardness and corrosion resistance of the alloy increase with rolling.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
