期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 39, 期 -, 页码 56-60出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.02.028
关键词
Layered double hydroxide; Vitamin C; Thermal stability; Controlled release; Drug delivery system
资金
- National Natural Science Foundation of China [51202054, 21206026, 81271665]
- Hebei Provincial Natural Science Foundation of China [B2012402006, B2012402011]
- Handan City Science and Technology Research and Development Project of China [1221120095-4]
A new drug delivery system for vitamin C (VC), Ca/Al layered double hydroxide (LDH), is demonstrated in this work. VC anions were intercalated successfully in the Ca/Al LDH gallery by a coprecipitation method. The inter-layer space of 9.8 angstrom suggests that VC anions are vertical to the LDH layers in the form of interdigitated bilayer. The loading of VC in LDH is 36.4 wt.%. The thermal stability of VC is significantly enhanced after intercalation. In vitro VC release results show that the release time of VC in a phosphate buffer at pH 7.4 was significantly extended, and the maximal percentage of VC released is 80% of the total. The Avrami-Erofe'ev equation most satisfactorily explains the release kinetics of VC, which is that the release of VC is mainly dominated by the ion-exchange reaction. (C) 2014 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据