4.3 Article

Evaluation of pristine and Eu2O3-added MgB2 ceramics for medical applications: hardness, corrosion resistance, cytotoxicity and antibacterial activity

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.05.046

关键词

MgB2 added with Eu2O3; Hardness; pH evolution in PBS; Corrosion; Cytotoxicity; Antibacterial activity

资金

  1. Core Program, Romania [PN-45N]
  2. European Social Fund [POSDRU/89/1.5/S/54785]

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Nano- or micropowders of Eu2O3 were added to MgB2, resulting in a composition of (MgB2)(0.975)(EuO1.5)(0.025). Pristine and doped samples were prepared using spark plasma sintering and tested for (i) Vickers hardness, (ii) pH evolution in phosphate-buffered saline solution, (iii) corrosion resistance (Tafel polarization curves), (iv) cytotoxicity (in vitro tests), and (v) antibacterial activity. Eu2O3 addition influenced the investigated properties. Solutions of MgB2-based samples show a relatively high saturation pH of 8.5. This value is lower than that of solutions incubated with Mg or other Mg-based biodegradable alloys reported in the literature. MgB2-based samples have lower electro-corrosion rates than Mg. Their Vickers hardness is 6.8-10.2 GPa, and these values are higher than those of biodegradable Mg-based alloys. MgB2 has low in vitro biocompatibility, good antibacterial activity against Escherichia coli, and mild activity against Staphylococcus aureus. Our results suggest that MgB2-based materials deserve attention in biomedical applications, such as implants or sterile medical instruments. (C) 2014 Elsevier B.V. All rights reserved.

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