Article
Chemistry, Multidisciplinary
Mingxin Wang, Somia Yassin Hussain Abdalkarim, Ruixin Gong, Haibin Ji, Zhiming Chen, Yunfei Shen, Ying Zhou, Jiayuan Shen, Hou-Yong Yu
Summary: Polymer composite microspheres with excellent biodegradable and controlled long-term release characteristics have gained significant attention. However, producing polymer microspheres with controlled properties and customizable drug release is still a major challenge. In this study, dual-responsive cellulose nanocrystals were engineered and incorporated into polylactide composite microspheres to achieve controlled and sustained drug release behavior. The results demonstrated a temperature and pH dual-responsive controlled drug release capability of the composite microspheres, highlighting their potential as multifunctional drug delivery systems for medical applications.
Article
Biochemistry & Molecular Biology
Nitika Mor, Neera Raghav
Summary: In this study, the chemical transformation of carboxymethylcellulose with curcumin in ester form resulted in the development of a target-specific sustained release delivery system for curcumin in the presence of liver esterases. The synthesis and characterizations of curcumin-carboxymethylcellulose ester (Cur-CMC ester) were reported, along with its target-specific hydrolysis for curcumin release. The stability of Cur-CMC ester was demonstrated in simulated in vitro gastric fluid (pH 1.2) and intestinal fluid (pH 6.8). Upon in vitro simulation in liver homogenate, curcumin was released from Cur-CMC ester in a consistent amount (approximately 43%) over 5 hours, with the highest release observed at pH 8.0 in the presence of liver enzymes. The findings suggest that modified CMC can serve as a delivery system for curcumin in the liver and act as a prodrug system, releasing free curcumin in the presence of liver esterases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Fang Luo, Ting Zhong, Ying Chen, Qianqian Guo, Ling Tao, Xiangchun Shen, Yanhua Fan, Xingjie Wu
Summary: Dual-ligand targeting nanoplatforms have shown promise for improving chemotherapy specificity, but off-target delivery persists as a problem. To address this, a dual-ligand synergistic targeting (DLST) nanoplatform was developed, which guides chemotherapy specifically to cancer cells overexpressing two receptors. This nanoplatform consists of two different nanocarriers decorated with complementary DNA sequences and loaded with singlet oxygen (O-1(2)) photosensitizer and drug, respectively. In vitro evaluation demonstrated its highly specific tumor treatment with minimized long-term toxicity, making it a highly efficient drug delivery system for DLST chemotherapy with great clinical potential.
Article
Chemistry, Multidisciplinary
Hsuan-Chen Liu, Daniel Davila Gonzalez, Dixita Ishani Viswanath, Robin Shae Vander Pol, Shani Zakiya Saunders, Nicola Di Trani, Yitian Xu, Junjun Zheng, Shu-Hsia Chen, Corrine Ying Xuan Chua, Alessandro Grattoni
Summary: This study demonstrates that sustained low-dose intratumoral delivery of CD40 monoclonal antibodies (mAb) via nanofluidic drug-eluting seed (NDES) can modulate the tumor immune microenvironment (TIME) and reduce tumor burden in pancreatic ductal adenocarcinoma (PDAC). NDES achieves tumor reduction at a lower dosage compared to systemic treatment and avoids treatment-related adverse events. Moreover, it also shows abscopal responses by inhibiting the growth of untreated tumors. Overall, NDES presents a minimally invasive and effective approach to overcome the immune barrier in PDAC for transforming treatment.
Article
Engineering, Biomedical
Shichen Liu, Yao Sun, Teng Zhang, Longtao Cao, Zhiwei Zhong, Haoxin Cheng, Qingqing Wang, Zhuang Qiu, Weimin Zhou, Xiaolei Wang
Summary: A targeted thrombolytic and anticoagulation nanoplatform based on upconversion nanoparticles has been developed, which can achieve synergistic thrombolysis and anticoagulation therapy through controlled release of urokinase and nitric oxide. In vitro and in vivo experiments have confirmed its excellent thrombolytic and anticoagulative capabilities, and its fluorescent imaging ability is expected to contribute to the development of clinical thrombolysis therapy.
BIOACTIVE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Elizabeth Magill, Sara Demartis, Elisabetta Gavini, Andi Dian Permana, Raghu Raj Singh Thakur, Muhammad Faris Adrianto, David Waite, Katie Glover, Camila J. Picco, Anna Korelidou, Usanee Detamornrat, Lalitkumar K. Vora, Linlin Li, Qonita Kurnia Anjani, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes, especially for the treatment of chronic conditions where patient adherence to conventional treatments can be challenging.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Physical
Liang Qiao, Fuhua Deng, Xulin Hu, Tianfang Huang, Junlin An, Dong Pan, Junqiang Yan, Gaofeng Liang, Jian He
Summary: This study presents a microsphere delivery system with efficient drug loading and controlled release. The system achieves dual sustained release, maintaining blood drug concentration for a longer time and reducing drug side effects.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Pharmacology & Pharmacy
Ben S. Ou, Olivia M. Saouaf, Julie Baillet, Eric A. Appel
Summary: The immune system plays a crucial role in regulating and protecting human health. Sustained release technologies have shown potential in enhancing adaptive immune responses by prolonging exposure to immunogenic signals.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Mahsa Haghighattalab, Abdolmohammad Kajbafzadeh, Mostafa Baghani, Ziba Gharehnazifam, Bahareh Mohammadi Jobani, Majid Baniassadi
Summary: The study developed magnetic silk fibroin hydrogel for controlled drug release, showing great potential for future applications in noninvasive and remotely controlled drug delivery systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Tobias Achu Muluh, Zhuo Chen, Yi Li, Kang Xiong, Jing Jin, ShaoZhi Fu, JingBo Wu
Summary: In recent years, there has been a significant increase in research on abnormal cell growth, particularly focusing on the management, treatment, and prevention of tumor recurrence. Cancer immunotherapy aims to educate the body's defensive system to prevent, control, and eliminate tumor cells, with the use of nanoparticles enhancing its effectiveness. By utilizing nanoparticles for precise delivery of immunotherapies to targeted neoplasms, immunotherapy can be a promising approach for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Yasamin Davatgaran Taghipour, Amir Zarebkohan, Roya Salehi, Fariborz Rahimi, Vladimir P. Torchilin, Michael R. Hamblin, Alexander Seifalian
Summary: The lack of efficient strategies for targeted delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) is a key issue in the treatment of solid tumors. This review focuses on dual targeting approaches, which combine biological strategies and physicochemical responsive smart delivery strategies, to increase the accumulation of nanoparticles within the TME and improve targeting efficiency towards cancer cells. The efficiency and rationale behind the choice of ligands for dual targeting strategies are critically reviewed. New approaches for smart drug delivery, including TME-specific responsive linkers and camouflaged nanoparticles, are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Nam H. B. Tran, Diem D. N. Nguyen, Ngoc Mai Nguyen, Chau Tran, Ngoc Thanh Nguyen Thi, Duyen T. K. Ho, Hoai-Nghia Nguyen, Lan N. Tu
Summary: The authors examined whether displaying multiple homing peptides on exosomes could enhance tumor targeting efficiency. Exosomes from HEK293F cells were engineered to display either single or dual tumor-penetrating peptides, iRGD and tLyp1. Results showed that dual iRGD-tLyp1 exosomes loaded with doxorubicin (Dox) significantly improved Dox uptake in breast cancer cell lines MCF-7 and MDA-MB-231, outperforming single iRGD or tLyp1 exosomes. The dual iRGD-tLyp1 exosomal Dox also exhibited the highest potency, with IC50/GI(50) values 3.7-17.0 times lower than free Dox and other exosomal Dox. Therefore, selecting appropriate combinations of homing peptides could be a promising strategy for precision nanomedicine.
Article
Nanoscience & Nanotechnology
Boddu Adilakshmi, Obireddy Sreekanth Reddy, Duddekunta Hemalatha, Kummari S. V. Krishna Rao, Wing-Fu Lai
Summary: Site-specific drug delivery systems using PEG as carriers have been widely adopted due to its favorable features. The development of carriers for hydrophobic anticancer agents remains a challenge. The developed drug conjugate PEGDA-MN-DOX shows anticancer potential, cancer-targeting ability, and ROS-generating capacity for effective drug encapsulation and sustained release in chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shuhui Song, Xinyi Li, Yongsheng Ji, Ruihong Lv, Le Wu, Haohao Wang, Mingzhuo Cao, Zhigang Xu
Summary: DDMSNs-DOX-HA, a dual-responsive and degradable drug delivery system, shows excellent drug loading capacity and targeting function for tumor cells. It exhibits higher cytotoxicity against tumor cells under GSH/pH-triggered environment, providing a potential tumor-specific targeting ability for cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qinghong Hou, Lulu Wang, Feng Xiao, Le Wang, Xiaoyan Liu, Lina Zhu, Yi Lu, Wenfu Zheng, Xingyu Jiang
Summary: A double targeting nanoparticle carrying lamotrigine has been designed to cross the blood-brain barrier and concentrate at the neurons, providing a new strategy for improving the therapeutic efficacy of existing antiepileptic drugs.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
