Article
Physics, Applied
Yumeng Zhao, Masashi Kurashina, Hitoshi Matsuki, Mikito Yasuzawa
Summary: In this study, the hydrophilicity and biocompatibility of surfaces modified with 2-methacryloyloxyethyl phosphorylcholine (MPC) were evaluated under different pH conditions. The MPC-modified surfaces exhibited high hydrophilicity at neutral pH due to ionization, but the hydrophilicity decreased under acidic conditions due to the decrease in negative charge. The biocompatibility was evaluated by measuring the prevention of fibrinogen adsorption, which was significantly lower on the MPC-modified surface at pH 7.6 compared to the bare glass, but increased at pH 2.8 indicating decreased biocompatibility.
MODERN PHYSICS LETTERS B
(2023)
Article
Materials Science, Multidisciplinary
Susu Huang, Yuelin Fang, Boguang Yang, Prabhleen Kaur, Yanqing Wang, Jicheng Zhang, Qiaoying Hu, Xiaoye Yang, Yabin Zhang, Guangxi Zhai, Lei Ye
Summary: Postoperative adhesions are a common complication after intraperitoneal surgery, with a high recurrence rate. A series of poly(sulfobetaine methacrylate) grafted dextran derivatives were synthesized, which can self-assemble into a physical hydrogel under physiological conditions, effectively preventing postoperative adhesions.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Wen-Yen Chang, Ching-Yi Chen
Summary: In this study, a long-lasting antibacterial nanofibrous mat was fabricated by integrating zwitterionic materials and antibacterial photodynamic therapy (aPDT) photosensitizer. The nanofibrous mat showed good water absorption and retention ability, excellent cytocompatibility, and antibiofouling ability. Under moderate irradiation, the mat exhibited superior aPDT against Gram-positive bacteria and had a long-lasting drug release profile that efficiently suppressed bacterial growth. Its antibacterial ability was comparable to antibiotics, suggesting its potential as an antibiotic alternative.
Article
Biophysics
Bingbing Zhu, Erna Jia, Qimeng Zhang, Yanyan Zhang, Hua Zhou, Ying Tan, Zhennan Deng
Summary: In this study, a successful construction of zwitterionic copolymers (poly (sulfobetaine methacrylate-co-butyl acrylate) (pSB) coating on the surface of a hydroxylated titanium sheet using surface-initiated atom transfer radical polymerization (SI-ATRP) was achieved. The successful preparation of the coating was confirmed by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and water contact angle (WCA) analysis. The swelling effect caused by the antipolyelectrolyte effect was observed in vitro, and the coating promoted the proliferation and osteogenesis of MC3T3-E1. Therefore, this study provides a new strategy for designing multifunctional biomaterials for implant surface modifications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biophysics
Ran Xu, Xuezhong Cui, Qiangwei Xin, Min Lu, Zhiqiang Li, Jianshu Li, Xingyu Chen
Summary: The modified Ti surface with PMCP can enhance antifouling properties and biological activity, promoting cell adhesion and proliferation of osteoblast-related cells. This has great potential in bone tissue engineering for improving the interaction between cells and biomaterials.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biophysics
Xue Zhao, Qiangwei Xin, Dongqiong Yang, Xingxing Zhai, Jing Li, Xingyu Chen, Jianshu Li
Summary: This study investigated the biocompatibility of PLA-PMCP films in terms of protein adsorption, cell adhesion and proliferation, bacterial adhesion, blood compatibility, and inflammation in vivo. The results showed that the PLA-PMCP surface can resist protein adsorption and bacterial adhesion, promote cell adhesion and proliferation, and have good hemocompatibility and histocompatibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Joaquim M. Rius-Bartra, Norma Ferrer-Serrano, Nuria Agullo, Salvador Borros
Summary: Flexible capacitive sensors based on silicone rubber are important in both academic and industrial fields due to their advantages, but they require dielectric additives to enhance electrical properties, which also increase Young's modulus. Liquid silicone rubbers are commonly used in academia, but compromise mechanical integrity, while high-consistency silicone rubbers maintain mechanical integrity but have limited use in dielectrics. This paper explores the potential of vinyl-terminated HCR for developing dielectric composites with high electromechanical response while retaining mechanical and processability properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Biomaterials
Jinjia Xu, Jian Xu, Haesoo Moon, Herman O. Sintim, Hyowon Lee
Summary: This study describes a newly designed multifunctional zwitterionic liquid crystalline polymer with good antibiofouling properties for biomedical applications. The polymer exhibits good conductivity, stability, and hydrophilicity, and effectively inhibits protein adsorption, cell growth, and bacteria attachment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Manufacturing
Jian Liu, Yin Yao, Shaohua Chen, Xiaohong Li, Zhijun Zhang
Summary: A new nanoparticle-reinforced silicone rubber composite with high strength and strong adhesion has been developed in this study, showing superior performance in adhesive properties and potential applications for advanced devices.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2021)
Article
Polymer Science
Qiming He, Yijun Qiao, Carlos Medina Jimenez, Ryan Hackler, Alex B. F. Martinson, Wei Chen, Matthew Tirrell
Summary: Zwitterionic brushes were synthesized and their structure was investigated using various techniques. The PCysMA brushes showed an antipolyelectrolyte effect related to the Hofmeister series of anions. The presence of divalent and trivalent ions had different impacts on the dimensions of the PCysMA brushes and their chelating interactions.
Article
Nanoscience & Nanotechnology
Qingsi Li, Yingnan Zhu, Yongjian Li, Jing Yang, Zhun Bao, Shu Tian, Xiaodong Wang, Lei Zhang
Summary: In this study, a simple strategy was developed to construct reusable and highly efficient bilirubin adsorbents for hemoperfusion application. The strategy involved incorporating zwitterionic modules into a porous organic polymer (POP) to improve its hemocompatibility, hydrophilicity, and bilirubin uptake. Among the tested zwitterions, POP-CB-40% showed the best bilirubin uptake, with a 46.5 times enhancement compared to the non-zwitterionic POP in 100% serum. Furthermore, it was found that POP-CB-40% maintained around 99% of its bilirubin uptake capacity after five cycles in 100% serum, indicating its reusability. These findings provide a helpful guideline for designing biocompatible and efficient POP-based bilirubin adsorbents for hemoperfusion therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Kun Wang, Theo Arado, Ardith Huner, Hyang Seol, Xuan Liu, Huifeng Wang, Lena Hassan, Karthika Suresh, Sangil Kim, Gang Cheng
Summary: A highly flexible zwitterionic thermoplastic polyurethane with critical antifouling properties was developed to prevent microbial contamination and biofilm formation. This study lays the foundation for understanding the structure-function relationships of zwitterionic polymers.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Ebad Noman, Sijia Zheng, Haiyan Xue, Michael A. Brook
Summary: This study presents an approach to repurposable and readily degradable silicone elastomers using alpha-lipoic acid. The resulting thermoplastic elastomers have properties that remain essentially unchanged after multiple heating cycles. Reduction of the disulfide linkages transforms the elastomers into oils, which can crosslink under air to give new elastomers with slightly higher mechanical properties. This process leads to elastomers that are more sustainable and facilitate reuse, repurposing, and recycling.
Article
Polymer Science
Dejin Zhang, Susu Zhao, Zhihao Rong, Kaiming Zhang, Chuanhui Gao, Yumin Wu, Yuetao Liu
Summary: A silicone coating with zwitterionic side chains and carbamates groups was developed, demonstrating good fouling resistance and mechanical properties. It showed strong substrate adhesion and low surface energy, making it suitable for marine antifouling coating and biomaterial interfaces.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Congkai Ma, Ting Han, Spyridon Efstathiou, Arkadios Marathianos, Hannes A. Houck, David M. Haddleton
Summary: A visible-light-regulated polymerization protocol was reported for the preparation of high-quality polymers with promising photopatterning capabilities. The method allows for the synthesis of complex copolymers and can be easily adapted for flow setups.
Letter
Cell Biology
Kai Zhang, Chang Zhou, Zemin Li, Xuehan Li, Ziyun Zhou, Linjia Cheng, Ahmed Hammad Mirza, Yumeng Shi, Bingbing Chen, Mengwei Zhang, Liujuan Cui, Congyan Zhang, Taotao Wei, Xuelin Zhang, Shuyan Zhang, Pingsheng Liu
Article
Food Science & Technology
Bingbing Chen, Yumeng Shi, Kai Zhang, Yanzhong Chang, Pengcheng Fu, Pingsheng Liu, Shuyan Zhang
Summary: Increased consumption of high-fat low-fiber foods is associated with the development of metabolic syndromes. Fermentable dietary fiber, such as inulin, can alleviate metabolic abnormalities. This study systematically investigated the effect of inulin on mice with metabolic disorders induced by short-term and long-term high-fat feeding. The results showed that inulin reduced body weight, improved glucose intolerance, and alleviated hepatic steatosis in both groups of mice, suggesting a potential mechanism mediated through the modulation of gut microbiota.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Zhuangzhuang Zhang, Qiao Hu, Jiaying Liao, Yifan Xu, Ruiqi Tian, Yichen Du, Jian Shen, Xiaosi Zhou
Summary: A self-templating strategy was used to prepare homogeneous P2-K0.6CoO2 (KCO) microcubes, which showed improved electrochemical properties for potassium storage due to the reduced interface between the electrolyte and the active material.
Article
Chemistry, Organic
Bo Dong, Yifeng Chen, Shubing Xie, Jieying Zhang, Jian Shen, Lan-Gui Xie
Summary: Oxidative cross-coupling of two thiols is a direct and desirable method for synthesizing unsymmetrical disulfides. However, the formation of symmetrical by-products is a major issue. This study presents a method where the homo-coupling of thiols is effectively inhibited by sequential addition of the thiols, utilizing the rapid oxidation of thiols by bromodimethylsulfonium bromide.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wan Peng, Cheng Liu, Youjin Lai, Yanting Wang, Pingsheng Liu, Jian Shen
Summary: Most bioadhesives are ineffective on bleeding tissues and postoperative adhesion is a common issue. A three-layer biodegradable Janus tissue patch (J-TP) is developed to efficiently close bleeding wounds, promote clotting, and prevent tissue adhesion. The J-TP's adhesive hydrogel bottom layer forms strong adhesion to bleeding tissues through chemical bonding, while the middle layer improves tensile strength and the top layer prevents postoperative adhesion and inflammation. This J-TP shows promise in the clinical treatment of injured bleeding tissues with inhibited adhesion.
Article
Engineering, Biomedical
Peiming Liu, Jin Sun, Wan Peng, Yahui Gu, Xiaoxue Ji, Zhi Su, Pingsheng Liu, Jian Shen
Summary: Good's buffers have been widely used in cell/organ culture as biocompatible pH stabilizers. However, the emergence of adverse effects such as cellular uptake, autophagic activation, and cytotoxicity under light exposure raises concerns over its biocompatibility. Riboflavin in the cell culture medium produces reactive oxygen species (ROS) under light exposure, causing severe toxicity and disruption of normal cell functions. Zwitterionic betaines have been identified as a new generation of biocompatible pH buffers that do not exhibit these adverse effects.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Cheng Liu, Huimin Gao, Gaoqi Sun, Xuefeng Jiang, Saijie Song, Jun Zhang, Jian Shen
Summary: In this study, a multifunctional decellularized scaffolds (DCS)-based vascular patch was designed for porcine vascular repair. By coating ammonium phosphate zwitter-ion (APZI) and poly(vinyl alcohol) (PVA) hydrogel on the surface of DCS, the mechanical properties and biocompatibility of the artificial vascular patch were improved. The artificial vascular patch was further decorated with a heparin (Hep)-loaded metal-organic framework (MOF) to inhibit blood coagulation and promote vascular endothelialization. The results showed that the obtained artificial vascular patch had suitable mechanical properties, good biocompatibility, and blood compatibility, making it an excellent vascular replacement material.
ACS APPLIED BIO MATERIALS
(2023)
Article
Engineering, Biomedical
Juyang Zhang, Baohong Sun, Ming Zhang, Yutian Su, Wang Xu, Yuhan Sun, Huijun Jiang, Ninglin Zhou, Jian Shen, Fan Wu
Summary: Single-atomic nanozymes characterized by atomically dispersed single metal atoms have shown satisfactory catalytic activity and superior selectivity compared to their nanoscale counterparts, contributing to breakthroughs in biomedicine. Adjusting the coordination number of the metal atoms can improve their catalytic performance. In this study, atomically dispersed Co nanozymes with different nitrogen coordination numbers were synthesized, and it was found that Co nanozymes with a coordination number of 2 had the highest catalytic activity and antibacterial effect. This research provides proof of concept for enhancing single-atomic catalytic therapy by regulating the coordination number for various biomedical applications.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Analytical
Qian Chen, Wenyan Guo, Dan Fang, Ting Li, Lin Chen, Chun Mao, Mimi Wan, Jian Shen
Summary: Efficient capture and detection of circulating tumor cells (CTCs) using Mg-Based micromotors was achieved, which is crucial for early cancer detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Juyang Zhang, Mengdi Lv, Xinye Wang, Fan Wu, Cheng Yao, Jian Shen, Ninglin Zhou, Baohong Sun
Summary: Nanozyme-driven catalytic antibacterial therapy using biomimetic nanoenzymes can effectively target inflamed areas and eliminate bacterial biofilms. This approach overcomes limitations of current biofilm wound treatments and offers potential for improved outcomes.
Article
Chemistry, Multidisciplinary
Lei He, Yongze Liu, Panpan Song, Fuqi Feng, Genyuan Li, Yuanyuan Ma, Juqing Cui, Xiaofeng Ma, Jian Shen, Jun Zhang
Summary: A highly efficient photothermal and flexible wood-based hydrogel has been successfully synthesized, which promotes the recovery of infected wounds and is nontoxic, renewable, and biodegradable. It exhibits good photothermal conversion efficiency and long-lasting antibacterial effects, making it a potential biomaterial for the treatment of infected skin wounds.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Materials Science, Biomaterials
Nian Liu, Xiangyu Xiao, Ziqiang Zhang, Chun Mao, Mimi Wan, Jian Shen
Summary: Cancer vaccines are a promising therapeutic strategy in clinical oncology, stimulating antitumor immunity to fight against cancer. However, there are several challenges that hinder their broad clinical translation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Changrui Ying, Xiaolong Zhu, Shuqing Xiang, Mingqian Wang, Xuefeng Jiang, Jian Shen
Summary: This article investigates carbon-based single-atom catalysts and their potential application in photothermal catalytic antimicrobial therapy. Iron single-atom catalysts demonstrate significant catalytic activity, producing a large amount of hydroxyl radicals that can kill bacteria. The excellent photothermal properties of carbon materials enable the catalyst to rapidly generate high temperatures, enhancing its catalytic activity. Results show that the synergistic antimicrobial strategy of chemodynamic therapy and photothermal therapy is highly effective against bacteria.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Cheng Liu, Huimin Gao, Gaoqi Sun, Xuefeng Jiang, Saijie Song, Jun Zhang, Jian Shen
Summary: In this study, a multifunctional decellularized scaffolds (DCS)-based vascular patch with improved mechanical properties and biocompatibility was designed. The surface of the patch was coated with ammonium phosphate zwitter-ion (APZI) and poly(vinyl alcohol) (PVA) hydrogel, followed by the decoration of a heparin (Hep)-loaded metal-organic framework (MOF) to inhibit blood coagulation and promote vascular endothelialization. The obtained artificial vascular patch showed suitable mechanical properties, good biocompatibility, and blood compatibility. It also demonstrated enhanced proliferation and adhesion of endothelial progenitor cells (EPCs). The results from imaging techniques confirmed the patency of the implanted artificial vascular patch.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Physical
Gaoqi Sun, Xuefeng Jiang, Cheng Liu, Saijie Song, Jun Zhang, Jian Shen
Summary: The abuse of antibiotics leads to bacterial resistance, and it is important to develop new strategies for efficient antibacterial and wound healing. This study introduces a FeS@LAB-35@Ti3C2 nanozyme that integrates photothermal and chemodynamic therapy for bacterial inhibition and wound healing.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
