Article
Polymer Science
Jingjing Mai, Steven Pratt, Bronwyn Laycock, Clement Matthew Chan
Summary: This study explores the synthesis of industrially relevant high-molecular-weight block copolymers PHBV-b-PHBV using high molecular weight hydroxy-functionalised PHBV starting materials coupled with facile diisocyanate chemistry. Two-step synthesis approach and one-step approach were compared, and both successfully produced block copolymers. However, the two-step synthesis was less effective in building molecular weight. Both synthetic approaches were affected by additional isocyanate reactions resulting in the formation of by-products, affecting the product performance.
Article
Polymer Science
Beatriz Melendez-Rodriguez, Sergio Torres-Giner, Maria A. M. Reis, Fernando Silva, Mariana Matos, Luis Cabedo, Jose Maria Lagaron
Summary: A new P(3HB-co-3HV-co-3HHx) terpolyester synthesized using fruit pulp as feedstock was melt-mixed with commercial PHBV to create miscible films for food packaging. As the content of P(3HB-co-3HV-co-3HHx) increased, the mechanical response of the films transitioned from brittle to ductile, with increased permeabilities to gases.
Review
Engineering, Environmental
Mohammad I. Ibrahim, Diya Alsafadi, Khalid A. Alamry, Mahmoud A. Hussein
Summary: PHBV, a biopolyester with biodegradability, biocompatibility, and being biobased, shows great potential to replace conventional non-degradable polymers. Its weaknesses in mechanical properties and processability drive research towards developing composite materials for various applications.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Polymer Science
Jose Luis Aparicio-Collado, Juan Jose Novoa, Jose Molina-Mateo, Constantino Torregrosa-Cabanilles, Angel Serrano-Aroca, Roser Sabater I Serra
Summary: This paper reports the preparation and characterization of semi-IPN of PHBV and PVA with conductive PPy nanoparticles. The hybrid semi-IPN hydrogels showed significantly increased conductivity with higher PPy nanoparticles content. The PHBV/PVA semi-IPN exhibited good thermal stability and reduced hydrogel swelling.
Article
Biochemistry & Molecular Biology
Changfeng Miao, Dong Meng, Yuling Liu, Fang Wang, Lu Chen, Zhaosong Huang, Xiangyu Fan, Pengfei Gu, Qiang Li
Summary: This study identified a phaC(R) gene encoding PHA synthase in Rhodoligotrophos defluvii, and successfully synthesized different content and structural PHA copolymers under different carbon source conditions, achieving efficient biosynthesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Sara Alfano, Francesca Pagnanelli, Andrea Martinelli
Summary: Polyhydroxyalkanoates (PHAs) are degradable polyesters with the potential to replace oil-based polymers. This study presents a new method using attenuated total reflection FTIR (ATR-FTIR) to rapidly determine the composition of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P3HBV), the most common PHA copolymer. The method proves to be useful for easy and rapid estimation of P3HBV composition.
Article
Polymer Science
Aline Luiza M. Carlos, Javier Mauricio A. Mancipe, Marcos L. Dias, Rossana M. S. M. Thire
Summary: Electrospinning is commonly used for micro- and nanofibers production, while solution blow spinning (SBS) provides a safer alternative for certain applications. In this study, core-shell fibers were produced using SBS with PHBV showing better morphology and stability. The core-shell structure allows for sustained release of bioactive agents, and rotating collectors can produce smaller diameter fibers effectively.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Carmen R. Tubio, Xabier Valle, Estela Carvalho, Joana Moreira, Pedro Costa, Daniela M. Correia, Senentxu Lanceros-Mendez
Summary: Poly(hydroxybutyrate-co-hidroxyvalerate) (PHBV) is a biodegradable polymer that can be used as a substitute for plastics made from fossil resources. By blending PHBV with poly(caprolactone) (PCL) and poly(lactic acid) (PLA), its properties can be improved, including morphology, wetting, structure, thermal, mechanical, and electrical characteristics. The addition of PCL and PLA also enhances the antibacterial activity of PHBV. This study demonstrates the potential of developing PHBV blends with PCL or PLA for specific applications.
Article
Biochemistry & Molecular Biology
Isabela F. Santos, Rodolfo M. Moraes, Simone F. Medeiros, Jaspreet K. Kular, Marcus A. Johns, Ram Sharma, Amilton M. Santos
Summary: Polymeric nanoparticles were developed without any matrix ligands on their surface to promote cell attachment and proliferation of human osteoblasts. The study demonstrated that cells readily attached and spread onto the nanoparticle surfaces compared to non-tissue culture polystyrene, indicating the potential of PHBV nanoparticles for cell attachment and growth in tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Silvia Bittolo Bon, Irene Chiesa, Davide Morselli, Micaela Degli Esposti, Paola Fabbri, Carmelo De Maria, Tommaso Foggi Viligiardi, Antonino Morabito, Giacomo Giorgi, Luca Valentini
Summary: This study reports the fabrication of two different three-dimensional architectures of regenerated silk (RS) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with embedded functionalities, which have potential clinical applications. Experimental data are supported by finite element simulations, demonstrating the possibility to program the shape-changing behavior of 3D printed structures. The synergic effect obtained by combining materials on appropriate architectures paves the way to potential clinical applications.
MATERIALS & DESIGN
(2021)
Article
Polymer Science
Joao Ricardo Pereira, Ana Margarida Rafael, Asiyah Esmail, Maria Morais, Mariana Matos, Ana Carolina Marques, Maria A. M. Reis, Filomena Freitas
Summary: This study developed porous scaffolds using biocomposites consisting of two biodegradable and biocompatible biopolymers: poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PHBHVHHx) and FucoPol, a bacterial polysaccharide. FucoPol acted as a bioemulsifier in the fabrication of PHA-based porous structures, resulting in scaffolds with improved mechanical properties and potential for tissue engineering applications.
Article
Biochemistry & Molecular Biology
Young Yun Jo, Soyoung Park, Gyeongtaek Gong, Soonjong Roh, Jin Yoo, Jung Ho Ahn, Sun-Mi Lee, Youngsoon Um, Kyoung Heon Kim, Ja Kyong Ko
Summary: This paper reports an improved artificial pathway for enhancing the 3HV component during PHBV biosynthesis from a structurally unrelated carbon source by Cupriavidus necator H16. By genetically manipulating the branched-chain amino acid pathways, a recombinant strain was developed to increase the intracellular accumulation of propionyl-CoA, a key precursor of the 3HV monomer. This recombinant strain produced 42.5% (g PHBV/g dry cell weight) PHBV with 64.9 mol% 3HV monomer from fructose as the sole carbon source.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Asiyah Esmail, Joao R. Pereira, Chantal Sevrin, Christian Grandfils, Ugur Deneb Menda, Elvira Fortunato, Abel Oliva, Filomena Freitas
Summary: The study investigated the processing of poly(hydroxyalkanoates) (PHAs) for porous scaffolds, with emulsion templating technique showing a good balance between porosity and hydrophilicity while maintaining mechanical properties. The copolymer P(3HB-co-3HV) exhibited the best overall performance, with lower crystallinity and higher flexibility.
Article
Polymer Science
Viktoryia Kulikouskaya, Viktoryia V. Nikalaichuk, Anton P. Bonartsev, Elizaveta A. Akoulina, Nikita Belishev, Irina Demianova, Dariana Chesnokova, Tatiana K. Makhina, Garina A. Bonartseva, Konstantin Shaitan, Kseniya S. Hileuskaya, Vera V. Voinova
Summary: Surface morphology plays a crucial role in cell attachment and proliferation. Different films with microstructured surfaces made of biodegradable polymers, poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-co-HV), of varying molecular weights were investigated. The study found that stem cells exhibit different behaviors depending on the surface morphology of the films.
Article
Microbiology
Haibo Yang, Junyu Chen, Ruchira Mitra, Qiong Xue, Hua Xiang, Jing Han
Summary: Deleting chromosomal origins can reduce DNA content and ploidy number in Haloferax mediterranei, leading to larger cell size and increased PHBV production. Transcriptome analysis shows downregulation of genes involved in primary metabolism and upregulation of genes related to starch utilization and PHBV monomer precursor supply.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Physical
Yalong Liu, Lijuan Xing, Qingsong Zhang, Qifeng Mu, Pengfei Liu, Kun Chen, Li Chen, Xiaoyong Zhang, Ke Wang, Yen Wei
COLLOID AND POLYMER SCIENCE
(2016)
Article
Biotechnology & Applied Microbiology
Rui Xue, Yalong Liu, Qingsong Zhang, Congcong Liang, Huazhen Qin, Pengfei Liu, Ke Wang, Xiaoyong Zhang, Li Chen, Yen Wei
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Chemistry, Physical
Haihui Bai, Qingsong Zhang, Tao He, Guo Zheng, Guoqing Zhang, Linbao Zheng, Shuqiong Ma
APPLIED CLAY SCIENCE
(2016)
Article
Materials Science, Multidisciplinary
Qing Wan, Meiying Liu, Yili Xie, Jianwen Tian, Qiang Huang, Fengjie Deng, Liucheng Mao, Qingsong Zhang, Xiaoyong Zhang, Yen Wei
JOURNAL OF MATERIALS SCIENCE
(2017)
Article
Chemistry, Applied
Ning Yang, Hao Zhang, Lu Shi, Xiaoting Hu, Yang He, Li Chen, Qingsong Zhang, Kongyin Zhao
REACTIVE & FUNCTIONAL POLYMERS
(2016)
Article
Chemistry, Applied
Wenjun Gao, Lijuan Xing, Qingsong Zhang, Kun Chen, Pengfei Liu, Li Chen, Ning Yang, Xiaoyong Zhang, Ke Wang, Yen Wei
REACTIVE & FUNCTIONAL POLYMERS
(2016)
Article
Chemistry, Multidisciplinary
Ke Wang, Xingliang Fan, Lingyun Zhao, Xiaoyong Zhang, Xiqi Zhang, Zhen Li, Qian Yuan, Qingsong Zhang, Zengfang Huang, Wensheng Xie, Yuanyuan Zhang, Yen Wei
Article
Chemistry, Multidisciplinary
Qifeng Mu, Qingsong Zhang, Lu Gao, Zhiyong Chu, Zhongyu Cai, Xiaoyong Zhang, Ke Wang, Yen Wei
Article
Materials Science, Biomaterials
Yingge Shi, Guanjian Zeng, Dazhuang Xu, Meiying Liu, Ke Wang, Zhen Li, Lihua Fu, Qingsong Zhang, Xiaoyong Zhang, Yen Wei
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Materials Science, Biomaterials
Chaochao Yang, Rui Xue, Qingsong Zhang, Shulin Yang, Pengfei Liu, Li Chen, Ke Wang, Xiaoyong Zhang, Yen Wei
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Polymer Science
Ning Yang, Yue Wang, Qingsong Zhang, Li Chen, Yiping Zhao
POLYMER DEGRADATION AND STABILITY
(2017)
Article
Chemistry, Applied
Pengfei Liu, Zhe Peng, Qingsong Zhang
REACTIVE & FUNCTIONAL POLYMERS
(2017)
Article
Chemistry, Multidisciplinary
Lijuan Xing, Zhigang Li, Qingsong Zhang, Yixuan Zhang, Pengfei Liu, Kailin Zhang
Article
Materials Science, Multidisciplinary
Ning Yang, Yue Wang, Qingsong Zhang, Li Chen, Yiping Zhao
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Li Zhigang, Zhang Yixuan, Zhang Qingsong, Ma Youwei, Hu Tao, Bai Haihui, Liu Pengfei, Wang Ke, Zhang Xiaoyong
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2017)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)