期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 33, 期 4, 页码 2266-2272出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2013.01.051
关键词
Polymer; Composite; Hydroxyapatite; Pore; In vitro bioactivity
资金
- Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A110416]
We synthesized poly(epsilon-caprolactone) (PCL)/hydroxyapatite (HA) composite microspheres with an aligned porous structure and evaluated their potential applications in bone tissue engineering. A range of HA particles (0, 5, 10 and 20 wt.% in relation to the PCL polymer) were added to a PCL solution in order to improve the biocompatibility of the porous PCL/HA composite microspheres. All the synthesized microspheres showed that the HA particles were distributed well in the PCL matrix, while preserving their aligned porous structure. The average size of the PCL/HA composite microspheres increased from 62 +/- 7 to 179 +/- 95 mu m with increasing HA content from 0 to 20 wt.%. The incorporation of the HA particles to the PCL polymer led to a considerable improvement in in vitro bioactivity, which was assessed by immersing the PCL/HA composite microspheres in simulated body fluid (SBF). A number of apatite crystals could be precipitated on the surface of the aligned porous PCL/HA composite microspheres after soaking in the SBF for 7 days. (C) 2013 Elsevier B.V. All rights reserved.
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