Article
Engineering, Biomedical
M. Vallet-Regi, A. J. Salinas
Summary: Mesoporous bioactive glasses (MBGs) play an important role in bone regeneration with their outstanding textural properties, quick bioactive responses, and biocompatibility. They can be enhanced by adding small amounts of oxide elements to provide additional biological capacities. MBGs are versatile in various forms and can be further improved by loading with biomolecules, drugs, and stem cells.
MATERIALS TODAY BIO
(2021)
Article
Chemistry, Multidisciplinary
Silvia Rodrigues Gavinho, Ana Sofia Padua, Laura Isabel Vilas Holz, Isabel Sa-Nogueira, Jorge Carvalho Silva, Joao Paulo Borges, Manuel Almeida Valente, Manuel Pedro Fernandes Graca
Summary: In this study, Bioglass 45S5 with added SrO or MgO was developed and its physical and biological properties were evaluated. The results showed that the addition of these ions promoted a slight increase in the number of non-bridging oxygens, decreased cell toxicity of Bioglass 45S5, and enhanced antibacterial effect.
Review
Engineering, Biomedical
Kai Zheng, Wen Niu, Bo Lei, Aldo R. Boccaccini
Summary: The regulatory functions of immune response in tissue regeneration, ways to modulate immune cell responses (especially macrophages), and the potential of bioactive glasses in bone regeneration and wound healing have been recognized. Understanding the immunomodulatory effects of BGs and the interactions with immune cells are crucial for enhancing tissue regeneration. Emerging research focuses on harnessing macrophage responses through active ions, surface functionalization, and controlled release of immunomodulatory agents for improved tissue regeneration.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Lidong Huang, Weiyu Gong, Guibin Huang, Jingyi Li, Jilin Wu, Yuguang Wang, Yanmei Dong
Summary: This study explored the effects of photobiomodulation (PBM) combined with bioactive glass (BG) on early angiogenesis. The results showed that the combination of PBM and BG significantly promoted endothelial cell proliferation, gene expression, and tubule formation. In vivo experiments confirmed that PBM induced early angiogenesis, with more vascular-like structures observed in the BG + PBM group.
BIOMEDICAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Mojtaba Mansoorianfar, Khashayar Shahin, Mariam Marlen Mirstrom, Dagang Li
Summary: This study developed a bioglass nanoparticle composite fabric with BG nanoparticles embedded between CNF layers. By enhancing osseoconductivity and increasing the Young's modulus of the fabric, it showed superior osteogenic potential and improved mechanical strength and structural stability.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Ceramics
J. M. Tainio, T. Anttila, J. Pohjola, D. S. Brauer, J. Massera
Summary: Understanding the crystallization mechanism and sintering ability of bioactive glasses is important for their application. This study investigated the crystallization and sintering properties of B12.5 borosilicate glasses containing varying amounts of magnesium and/or strontium. The results showed that the addition of magnesium and strontium facilitated sintering and densification, and the crystallization had unexpected effects on the bioactivity of the glasses.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Yueh-Ling Chao, Tong-Mei Wang, Hao-Hueng Chang, Li-Deh Lin
Summary: The study investigated the potential of low-dose rhBMP-2 combined with a composite material in repairing peri-implant critical size defects, with results showing that HAp/TCP/Col +0.2 mg/ml rhBMP-2 demonstrated strong osteogenic potential and improved implant stability.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mehdi Azizi, Amin Shavandi, Masoud Hamidi, Shayan Gholizadeh, Mahnaz Mohammadpour, Mohammad Saeid Salami, Hadi Samadian
Summary: Tissue engineering is an innovative approach that combines engineering, biomaterials, and biomedicine to improve conventional bone defect treatment. This study developed bioengineered electroactive and bioactive mineralized carbon nanofibers as a scaffold for bone tissue engineering. The fabricated scaffold showed osteoactivity, electrical conductivity, and biocompatibility, making it an effective solution for bone tissue engineering.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Materials Science, Multidisciplinary
Muhammad Saad Shaikh, Muhammad Amber Fareed, Muhammad Sohail Zafar
Summary: Tissue engineering in the orofacial region is focused on utilizing immune complexes or other proteins to activate bioactive components and create natural ground materials and tissue components. Bioactive glass, a promising biomaterial, has been found suitable for various clinical dental applications, including regeneration of hard tissues. This review highlights the favorable properties and recent applications of bioactive glass materials for managing periodontal lesions, emphasizing its potential in repairing bone defects, gum recession, and guiding tissue regeneration. However, further research and clinical trials are needed to validate the potential and translate the use of bioactive glass in dental clinics for periodontology.
Review
Engineering, Biomedical
Adam Shearer, Maziar Montazerian, Jessica J. Sly, Robert G. Hill, John C. Mauro
Summary: At least 25 bioactive glass medical devices have been approved for clinical use worldwide. These devices have diverse applications, including implants, fillers, agents for dentin hypersensitivity, wound dressing, and cancer therapeutics. Bioactive glasses have evolved in morphology and delivery systems, allowing for greater flexibility and control. This article critically discusses the approved products, regulatory standards, and the future development, applications, and challenges of bioactive glasses.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Daun Kim, Yonghyun Gwon, Sunho Park, Woochan Kim, Kwidug Yun, Jangho Kim
Summary: The study developed a polycaprolactone-based scaffold for bone regeneration with a soluble eggshell membrane protein coating and nanotopography structure, exhibiting flexibility and mechanical strength. In vitro experiments showed that the scaffold could regulate and enhance cell morphology, adhesion, proliferation, and differentiation.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Pharmacology & Pharmacy
Maria Vallet-Regi, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone, Sonia Fiorilli
Summary: Mesoporous bioactive glasses (MBGs) are highly promising candidates in the field of bioceramics for bone tissue regeneration, thanks to their unique chemical composition, structural and surface properties. Recent research has focused on optimizing the texture and structure of MBGs and exploring their potential as multitherapy systems, particularly in the context of local drug delivery. This article provides an overview of the latest developments in MBGs for bone tissue engineering, multifunctionalization, and drug delivery, as well as discussing the current challenges and future directions for clinical translation of MBGs.
Article
Engineering, Biomedical
Peng Guo, Xizhe Liu, Penghui Zhang, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqian Zhou, Xuenong Zou, Danny Chan, Wei Tian, Dafu Chen, Manman Gao, Zhiyu Zhou, Shaoyu Liu
Summary: This study maps the transcriptional landscapes of different osteogenic microenvironments for mesenchymal stromal cells (MSCs) at single-cell resolution, providing insights into the regulation of bone regeneration by three-dimensional hydroxyapatite (HA) scaffolds and osteogenic medium (OM). The research reveals that HA scaffolds activate osteogenic-related signaling pathways and inhibit adipogenesis and fibrosis, while OM mediates osteogenesis through the ZBTB16 and WNT signaling pathways. The study also demonstrates the heterogeneity of MSCs and provides new directions for improving osteogenic biomaterials.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Ceramics
Aylin M. Deliormanli, Mertcan Ensoylu, Ghada ALMisned, H. O. Tekin
Summary: In this study, polycaprolactone (PCL) and polylactide-co-glycolide (PLGA) coated bioactive glass scaffolds containing molybdenum disulfide (MoS2) nanoparticles were prepared and evaluated for their usability in bone tissue engineering applications. The results showed that the presence of MoS2 nanoparticles in the polymer matrix improved the mechanical properties of the scaffolds and increased the hydroxyapatite-forming ability of the bioactive glass-based composites. Additionally, the composite scaffolds demonstrated high radiation-shielding ability due to the presence of MoS2 nanoparticles.
CERAMICS INTERNATIONAL
(2023)
Article
Cell & Tissue Engineering
Natascia Cozza, Felipe Monte, Walter Bonani, Pranesh Aswath, Antonella Motta, Claudio Migliaresi
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Chemistry, Physical
Sujay Bagi, Vibhu Sharma, Pranesh B. Aswath
Review
Construction & Building Technology
R. Ralegaonkar, H. Gavali, P. Aswath, S. Abolmaali
CONSTRUCTION AND BUILDING MATERIALS
(2018)
Article
Materials Science, Ceramics
Cristiano Carlomagno, Giorgio Speranza, Pranesh Aswath, Gian Domenico Soraru, Claudio Migliaresi, Devid Maniglio
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2018)
Article
Cell & Tissue Engineering
Felipe Monte, Tugba Cebe, Daniel Ripperger, Fareed Ighani, Hristo V. Kojouharov, Benito M. Chen, Harry K. W. Kim, Pranesh B. Aswath, Venu G. Varanasi
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Engineering, Chemical
Vinay Sharma, Jens Johansson, Richard B. Timmons, Braham Prakash, Pranesh B. Aswath
Article
Dentistry, Oral Surgery & Medicine
Margot Bacino, Vishavjeet Girn, Hamid Nurrohman, Kuniko Saeki, Sally J. Marshall, Laurie Gower, Ella Saeed, Ray Stewart, Thuan Le, Grayson W. Marshall, Stefan Habelitz
Article
Dentistry, Oral Surgery & Medicine
S. C. Bayne, J. L. Ferracane, G. W. Marshall, S. J. Marshall, R. van Noort
JOURNAL OF DENTAL RESEARCH
(2019)
Article
Engineering, Chemical
Vibhu Sharma, Nicole Doerr, Ali Erdemir, Pranesh B. Aswath
Article
Dentistry, Oral Surgery & Medicine
Neha Saxena, Stefan Habelitz, Grayson W. Marshall, Laurie B. Gower
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Grayson W. Marshall, Sally J. Marshall, Stephen C. Bayne
Article
Dentistry, Oral Surgery & Medicine
Hamid Nurrohman, Stefan Habelitz, Kuniko Saeki, Alireza Sadr, Laurie B. Gower, Vanessa Pazdernik, Junji Tagami, Sally J. Marshall, Grayson W. Marshall
DENTAL MATERIALS JOURNAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Elham Babaie, Margot Bacino, Joel White, Hamid Nurrohman, Grayson W. Marshall, Kuniko Saeki, Stefan Habelitz
Summary: The study evaluated the efficacy of remineralizing dentin lesions using the Polymer-Induced Liquid Precursor (PILP) method with polyaspartic acid (pAsp). Novel ionomeric cement compositions and conditioning solutions were tested on demineralized dentin blocks with different lesion depths. Significant improvements in mechanical properties were observed in artificial lesions treated with PILP-releasing restoratives compared to traditional restoration methods without pAsp. Natural lesions also showed increased mineral volume content with PILP treatment. However, full recovery to normal mineral levels was not achieved in any of the natural lesions.
JOURNAL OF DENTISTRY
(2021)
Article
Materials Science, Coatings & Films
Sujay Bagi, Kimaya Vyavhare, Pranesh B. Aswath
TRIBOLOGY-MATERIALS SURFACES & INTERFACES
(2018)
Article
Health Policy & Services
Natalie B. Hastings, Linda S. Centore, Stuart A. Gansky, Frederick C. Finzen, Joel M. White, Eric Wong, Grayson W. Marshall, Lisa Chung, Elsbeth Kalenderian
JOURNAL OF HEALTHCARE LEADERSHIP
(2018)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
