Article
Nanoscience & Nanotechnology
Alex C. Tseng, Toshiya Sakata
Summary: This study successfully integrated the high electrical performance of poly(3,4-ethylenedioxythiophene) complexed with poly(styrenesulfonate) and the structural and electrochemical functions of a poly(acrylamide) second network incorporating phenylboronicacid in composite hydrogels. The free-standing hydrogels showed excellent performance in terms of hydration and conductivity, and could be used as channels for organic electrochemical transistors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Elnaz Zeynaloo, Elsayed M. Zahran, Yu-Ping Yang, Emre Dikici, Trajen Head, Leonidas G. Bachas, Sylvia Daunert
Summary: This study introduces a new method of using unnatural amino acids as protein labels, which not only changes the local microenvironment but also has minimal impact on the overall structure. By incorporating L-DOPA into the protein, it can be used as an electrochemical label for highly selective and sensitive detection of glucose.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Nanoscience & Nanotechnology
Fupeng Gao, Chunxiu Liu, Lichao Zhang, Tiezhu Liu, Zheng Wang, Zixuan Song, Haoyuan Cai, Zhen Fang, Jiamin Chen, Junbo Wang, Mengdi Han, Jun Wang, Kai Lin, Ruoyong Wang, Mingxiao Li, Qian Mei, Xibo Ma, Shuli Liang, Guangyang Gou, Ning Xue
Summary: Flexible wearable sweat sensors have attracted significant attention for their potential applications in personalized health monitoring, allowing continuous, real-time, noninvasive detection of sweat analytes and providing insights into human physiology at the molecular level. Electrochemical sensors are the best choice for these sensors due to their high performance, low cost, miniaturization, and wide applicability. Recent advancements in soft microfluidics, multiplexed biosensing, energy harvesting devices, and materials have improved the compatibility and performance of wearable electrochemical sweat-sensing platforms.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Chemistry, Analytical
Xiaohua Tian, Yonghai Feng, Liang Yuan, Yuqing Duan, Lei Liu, Mingdong Dong
Summary: The study introduced a dynamic electrochemical biosensor for specific capture, rapid detection, and non-invasive release of target tumor cells, showing high detection sensitivity and good selectivity. The biosensor represents a promising platform for tumor cell detection and monitoring of cell capture and release, providing a potential approach for early diagnosis of tumorigenesis and metastasis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Multidisciplinary
M. A. Khaleque, M. I. Hossain, M. R. Ali, M. S. Bacchu, M. Aly Saad Aly, M. Z. H. Khan
Summary: In recent years, there has been a rapid increase in demand for wearable sensors, particularly those tracking the surroundings, fitness, and health of people. This review surveys the latest research on nanostructured wearable electrochemical and biosensors, aiming to help researchers and engineers choose suitable sensors. Wearable sensors, such as contact lenses, Google Glass, and skin-patch, have broad sensing platforms. Improvements in sensor reliability, precision, stability, and sample conveyance are necessary. The future of wearable electrochemical sensors in healthcare and well-being fields is discussed, highlighting their potential impact on daily lives.
Article
Chemistry, Applied
Hsin-Yueh Chang, Lien-Chen Fu, He-Shin Huang, Yao-Chun Yeh, Mei-Yu Yeh
Summary: Diabetes is a global public health issue with significant consequences for daily functioning and health. A glucose sensor based on hydrazide-hydrazone phenyl-boronic acid (PBA) molecules has been developed, which does not require alkaline agents. Compound 3a showed high sensitivity to glucose due to intramolecular Lewis acid-base interactions, while compound 3c demonstrated selective glucose detection through intermolecular Lewis acid-base interactions.
Article
Chemistry, Physical
Wenrui Zhang, Junlin Ma, Fanxing Meng, Yu Jiang, Liuxue Shen, Tongrui Sun, Yanan Qin, Nan Zhu, Minwei Zhang
Summary: The successfully synthesized core-shell Prussian blue nanomaterials with high electrochemical activity, water solubility, and stability were used to construct wearable sensors using screen printing technology for the detection of biomarkers with high sensitivities. The combination of microfluidic technology is expected to enable large-scale health management monitoring and clinical applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Nanoscience & Nanotechnology
Qiong Ma, Xi Zhao, Anhua Shi, Junzi Wu
Summary: Glucose-sensitive self-adjusting drug delivery system mimics the physiological model of insulin secretion from the human pancreas, controlling blood sugar by precisely regulating the release of hypoglycemic drugs, showing promising application prospects in diabetes treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Guangna Ji, Wenyan Zhu, Xuexia Jia, Shuaifeng Ji, Dianpeng Han, Zhixian Gao, Hui Liu, Yu Wang, Tie Han
Summary: Effective and real-time detection of lactate (LA) content in human sweat has gained significant attention. A novel electrochemical paper-based analysis device (ePAD) was developed for non-invasive detection of LA in sweat. The study investigated the electrocatalytic properties of AuNP/Cu-TCPP(Fe) hybrid nanosheets and optimized the lactate sensor for usability and interpretability. The ePAD showed superior biocompatibility, accuracy, and high sensitivity, making it applicable for long-term monitoring of sweat LA concentrations in various extreme environments.
Article
Chemistry, Analytical
Nyan-Hwa Tai, Meng-Hsien Lin, Shivam Gupta, Ching Chang, Chi-Young Lee
Summary: In this research, a novel electrode was developed for noninvasive glucose sensing, which can determine glucose levels in saliva. The electrode consists of carbon nanotubes grown on a fluorine-doped tin oxide coated glass substrate, with glucose oxidase immobilized using polyethylenimine. The electrode demonstrated enhanced charge transferability and stable immobilization of glucose oxidase. It exhibited fast electron transfer rate, short electron transfer distance, and high sensitivity and stability towards glucose in artificial saliva. This research shows great potential for practical applications.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Annika Musse, Francesco La Malfa, Virgilio Brunetti, Francesco Rizzi, Massimo De Vittorio
Summary: The study developed a flexible glucose biosensor using a gold electrode and chronoamperometric measurements at different potentials to determine the linear range and detection limit, suitable for on-site testing for various body fluids, especially for non-invasive sweat sensing wearables.
Article
Chemistry, Physical
Mohammad Javed Ansari, Dmitry Olegovich Bokov, Saade Abdalkareem Jasim, Mohammad Rudiansyah, Wanich Suksatan, Ghulam Yasin, Supat Chupradit, Ayad F. Alkaim, Yasser Fakri Mustafa, Dhuha Imad Tarek
Summary: This article introduces the methods and technological breakthroughs in detecting CFX residues in food and water resources in recent years, with a focus on electrochemical and optical nanoprobes, and discusses their advantages and limitations.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Electrical & Electronic
Jinze Li, Xin Liu, Hao Sun, Liming Wang, Jianqi Zhang, Xi Huang, Li Deng, Jiawei Xi, Tianhong Ma
Summary: The immobilization of enzymes is a key factor in biosensor development. This study successfully used the electrospinning method to immobilize enzymes on optical fiber sensors, demonstrating high sensitivity in detecting glucose with promising potential for further development.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Analytical
Didem Nur Unal, Selenay Sadak, Bengi Uslu
Summary: There has been an increasing interest in the field of sensors for ionic liquids due to their unique properties, such as electrochemical and radiolytic stability, and the ability to synthesize a large number of variations with different anions and cations. Ionic liquids are preferred for fabricating electrochemical, optical sensors, and biosensors, as well as for use in electrolyte solutions. They offer advantages such as increased conductivity, optical properties, and stability, lower detection limits, enhanced electron transfer, and increased effective surface area of electrodes and sensor platforms. The use of nanomaterials in sensor modification further enhances these properties.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Irina Georgiana Munteanu, Constantin Apetrei
Summary: Chlorogenic acid, a phenolic compound, has various beneficial effects on human health including inhibiting carcinogenesis, antioxidant properties, and anti-inflammatory activities. Several methods have been developed to determine chlorogenic acid content, with some limitations in terms of being time-consuming and requiring expensive instruments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Tomohiro Seki, Misato Namiki, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki
Article
Pharmacology & Pharmacy
Yutaro Hazama, Toshihisa Maekawa, Ryotaro Miki, Shinji Oshima, Yuya Egawa, Kazuhiro Morimoto, Toshinobu Seki
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2016)
Article
Medicine, Research & Experimental
Tomohiro Seki, Keigo Abe, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki
MOLECULAR PHARMACEUTICS
(2016)
Article
Chemistry, Organic
N. Shimomura, Y. Egawa, R. Miki, T. Fujihara, Y. Ishimaru, T. Seki
ORGANIC & BIOMOLECULAR CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Chihiro Takei, Yui Ohno, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Yuya Egawa
CHEMICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Medicine, Research & Experimental
Ryotaro Miki, Chihiro Takei, Yasushi Ohtani, Kosuke Kawashima, Ayaka Yoshida, Yu Kojima, Yuya Egawa, Toshinobu Seki, Daisuke Iohara, Makoto Anraku, Fumitoshi Hirayama, Kaneto Uekama
MOLECULAR PHARMACEUTICS
(2018)
Article
Chemistry, Medicinal
Katsunori Shinohara, Miki Yamashita, Wataru Uchida, Chie Okabe, Shinji Oshima, Masahiro Sugino, Yuya Egawa, Ryotaro Miki, Osamu Hosoya, Takashi Fujihara, Yoshihiro Ishimaru, Tohru Kishino, Toshinobu Seki, Kazuhiko Juni
CHEMICAL & PHARMACEUTICAL BULLETIN
(2014)
Article
Chemistry, Physical
Keisuke Suwa, Munenari Nagasaka, Satoshi Niina, Yuya Egawa, Toshinobu Seki, Jun-ichi Anzai
COLLOID AND POLYMER SCIENCE
(2015)
Review
Chemistry, Physical
Yuya Egawa, Ryotaro Miki, Toshinobu Seki
Article
Materials Science, Biomaterials
Ryota Watahiki, Katsuhiko Sato, Keisuke Suwa, Satoshi Niina, Yuya Egawa, Toshinobu Seki, Jun-Ichi Anzai
JOURNAL OF MATERIALS CHEMISTRY B
(2014)
Article
Chemistry, Multidisciplinary
Wataru Uchida, Maiki Yoshikawa, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Takashi Fujihara, Yoshihiro Ishimaru, Yuya Egawa
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Yu Kojima, Tomoyuki Okano, Tomohiro Seki, Misato Namiki, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Tomohiro Seki, Keigo Abe, Kiminobu Nakamura, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2015)
Article
Pharmacology & Pharmacy
Toshinobu Seki, Airi Hamada, Yuya Egawa, Tsutomu Yamaki, Masaki Uchida, Hideshi Natsume, Soichiro Kimura, Hideo Ueda
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2013)
Article
Chemistry, Multidisciplinary
Yuki Kobayashi, Yu Kojima, Ryotaro Miki, Toshinobu Seki, Takashi Fujihara, Yoshihiro Ishimaru, Yuya Egawa
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2018)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)